Development of a specific and sensitive LC-MS/MS method to quantify Heparan Sulfate 3-O-Sulfotransferase-1 activity [0.03%]
高效液相色谱串联质谱检测硫酸肝素3-O-磺基转移酶-1活性的方法学研究
Vivien Uyen Doan,Yongmei Xu,Zhangjie Wang et al.
Vivien Uyen Doan et al.
Heparan sulfate (HS) is a highly sulfated glycan that regulates diverse biological processes through specific sulfation patterns. Among these, 3-O-sulfation catalyzed by heparan sulfate 3-O-sulfotransferase-1 (3OST-1) is rare but functional...
Exploratory analyses of cervicovaginal mucus O-glycan composition and microbiota profiles in unexplained infertility [0.03%]
不明原因不孕患者的宫颈黏液O-聚糖组分和微生物群系的探索性研究分析
Schahzad Saqib,Dimitrios Latousakis,Seppo Virtanen et al.
Schahzad Saqib et al.
In addition to the specific causes of infertility, two components of the vaginal ecosystem, the vaginal microbiota and the cervicovaginal mucus (CVM), may be associated to reduced fecundity and the success of infertility treatments. The aim...
Comprehensive analysis of gp120 glycosylation to explore differences between transmitter/founder and chronic HIV-1 isolates [0.03%]
全面分析gp120糖基化以探讨HIV-1传染株/优势株与慢性感染毒株之间的差异
Stephen Temesy,Jordan Haly,Yingxue Sun et al.
Stephen Temesy et al.
The extraordinary genetic diversity of HIV variants and their differences in glycosylation of surface protein gp120 have hindered developing a universal vaccine. Via lectin-mediated interactions, the gp120 glycans may trap viruses at the mu...
Hydroxyl radical-mediated oxidative modification of Camellia sinensis (L.) Kuntze cell-wall polysaccharides alleviates obesity by modulating glucose and lipid metabolism [0.03%]
茶树细胞壁多糖的羟自由基介导氧化修饰通过调节糖脂代谢缓解肥胖症状
Wenxuan Sun,Shengdong Chen,Han Shu et al.
Wenxuan Sun et al.
Due to the structural rigidity of tea cell walls and low solubility of their polysaccharides (TCWPs), along with unclear anti-obesity potential, this study extracted TCWPs via a novel hydroxyl radical oxidation. Using a high-fat diet-induce...
On the use of glycoengineering methods for the generation of antibodies with enhanced effector functions [0.03%]
糖工程方法在制备具有增强效应功能的抗体中的应用分析
Benjamin Serafin,Olivier Henry,Gregory de Crescenzo
Benjamin Serafin
Glycosylation is a non-template driven cellular process wherein sugars are enzymatically attached to proteins or lipids. For IgG, the most abundant class of therapeutic antibodies, glycosylation at position N297 contributes extensively to t...
N-Glycan Branching on Plasma Proteins: A Sweet Fingerprint of Coronary Artery Disease [0.03%]
血浆蛋白的N-聚糖分支：冠状动脉疾病的甘甜指纹
Barbara Radovani Trbojević,Frano Vučković,Aldo P Maggioni et al.
Barbara Radovani Trbojević et al.
Cardiovascular diseases (CVD) are the leading cause of death globally, with coronary artery disease (CAD) as the most prevalent single cause. While previous studies, including our own, have highlighted the role of immunoglobulin G (IgG) gly...
Polysialic acid is associated with immune activation in human peripheral blood nuclear cells [0.03%]
多唾液酸与人体外周血核细胞免疫活化相关
Sogand Makhsous,Carmanah Hunter,Vincent Gélinas et al.
Sogand Makhsous et al.
Immune dysregulation is a persistent state in which cells of the immune system become activated at low levels for long periods of time. If left unchecked, this chronic inflammation can lead to the development of chronic inflammatory disease...
N-glycan mass spectrometry imaging - a valuable tool for biomarker discovery and validation [0.03%]
N-糖肽质谱成像在生物标志物发现和验证中的应用价值研究
Anand S Mehta,Peggi M Angel,Richard R Drake
Anand S Mehta
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) enables spatially resolved detection of diverse biomolecules directly from tissues, supporting pathology-guided and unbiased biomarker discovery. By maintaini...