Siglec-15 binds mucin-domain glycoproteins with extended glycans and marks an osteoclast-like, matrix remodeling myeloid state in human tumors [0.03%]
Siglec-15与具有延伸糖链的黏蛋白结构域糖蛋白结合并标记人类肿瘤中的破骨细胞样基质重塑髓系状态
Nohelly Derosiers,William Aguilar,Hyeon-Gyu S Lewis et al.
Nohelly Derosiers et al.
Siglec-15 has emerged as a therapeutic target in cancer, yet the glycan determinants and protein scaffolds that mediate engagement between Siglec-15-expressing myeloid cells and tumor cells remain incompletely defined. Here, we investigated...
Mapping ST3GAL Transferase Specificities in the Glycosylation Landscape of N/TERT-1 Keratinocytes Using Glycogenomics and Mass Spectrometry [0.03%]
采用糖组学和质谱技术绘制N/TERT-1角质形成细胞糖基化图谱中的ST3GAL转移酶特异性分布图
Agnes L Hipgrave Ederveen,Ming Song,Tao Zhang et al.
Agnes L Hipgrave Ederveen et al.
Glycan sialylation is vital for proper cellular function and signaling. The six-membered ST3GAL family of sialyltransferases catalyzes the transfer of sialic acid in an α2,3-linkage to galactose residues on the outermost glycan epitopes. D...
Distinct properties of Hbt. Salinarum Agl32, an archaeal D-glucuronyl C5-epimerase involved in N-glycosylation [0.03%]
一种参与N-糖基化的古细菌D-葡糖醛酸C5差向异构酶Hbt.SalinarumAgl32的独特性质
Antonella Aquilone,Yarin Levi,Marianna Zaretsky et al.
Antonella Aquilone et al.
The N-linked tetrasaccharide decorating glycoproteins of the halophilic archaea Halobacterium salinarum offered the first example of N-glycosylation outside the Eukarya and still represents the only known instance of iduronic acid (IdoA) be...
Sialylation profile and Siglec-E expression across tissues in the B16OVA melanoma mouse model [0.03%]
B16OVA黑色素瘤小鼠模型中组织唾液酸化谱及Siglec-E表达分布
Magali Coccimiglio,Tao Zhang,Katarzyna Olesek et al.
Magali Coccimiglio et al.
Increased sialylation of tumour cells, which favours tumour growth and immune evasion, has been described using in vitro and in vivo models, leading to the first in-human clinical trial targeting sialylation in cancer. One important limitat...
Glyco you should know [0.03%]
你应该了解的糖类知识
Konstantinos Flevaris
Konstantinos Flevaris
Cellular homeostasis of N-acetylneuraminic acid and non-canonical sialic acids is mediated by human N-acetylneuraminate lyase [0.03%]
人唾液酸酶介导细胞内神经氨酸和非经典唾液酸的稳态平衡
Sjanie Huang,Iris Harmsen,Moritz Rahm et al.
Sjanie Huang et al.
Sialic acids are important for cellular communication, with N-acetylneuraminic acid (Neu5Ac) being the canonical form of sialic acid in humans. Presence of non-canonical sialic acids, derived from dietary intake or as metabolic side product...
Site-specific N-glycosylation analysis of bovine immunoglobulin M and its secretory form [0.03%]
牛免疫球蛋白M及其分泌型形式的位点特异性N-糖基化分析
Sudarshan Marihonnaiah,Gnanesh Kumar Belur Shivappa
Sudarshan Marihonnaiah
Bovine immunoglobulin M (IgM) from serum and colostrum has got considerable attention due to its immunological property against certain human pathogens. N-glycosylation being a key structural modification of IgM wherein glycan diversity exh...
Glyco you should know [0.03%]
你应该知道的糖化学
Natalie Stewart
Natalie Stewart
Comprehensive analysis of the skeletal phenotype in Chst14 -/- mice: implications for dermatan sulfate in bone structure and strength [0.03%]
基于Chst14基因敲除小鼠的骨骼表型的全面分析及其对透明质酸硫酸酯糖胺聚糖在骨结构和强度作用的启示
Yuki Takahashi,Takahiro Yoshizawa,Shuji Mizumoto et al.
Yuki Takahashi et al.
Dermatan sulfate (DS) is a glycosaminoglycan known to contribute to tissue strength through collagen fibril assembly. Musculocontractural Ehlers-Danlos syndrome (mcEDS) caused by pathogenic variants in the gene that encodes carbohydrate sul...