The mitochondrial protein YME1 Like 1 is important for non-small cell lung cancer cell growth [0.03%]
线粒体蛋白yme1_like_1在非小细胞肺癌细胞增殖中起重要作用
Yingchen Xia,Chunyan He,Zhi Hu et al.
Yingchen Xia et al.
The expression and biological function of the mitochondrial inner membrane protease YME1L (YME1 Like 1 ATPase) in NSCLC are tested here. Bioinformatical analyses and results from local human tissues show that YME1L expression is elevated in...
PYGL-mediated glucose metabolism reprogramming promotes EMT phenotype and metastasis of pancreatic cancer [0.03%]
PYGL介导的葡萄糖代谢重编程促进胰腺癌上皮间质转化表型及转移能力增强
Qian Ji,Hengchao Li,Zhiwei Cai et al.
Qian Ji et al.
Epithelial-mesenchymal transition (EMT) is closely associated with tumor invasion and metastasis. However, key regulators of EMT in pancreatic ductal adenocarcinoma (PDAC) need to be further studied. Bioinformatics analyses of pancreatic ca...
Targeting the KLF5-EphA2 axis can restrain cancer stemness and overcome chemoresistance in basal-like breast cancer [0.03%]
靶向KLF5-EphA2轴可抑制基底样乳腺癌的癌症干细胞特性并克服耐药性
Ping Zhao,Jian Sun,Xinwei Huang et al.
Ping Zhao et al.
Ephrin type-A receptor 2 (EphA2) is a member of the tyrosine receptor kinases, a family of membrane proteins recognized as potential anticancer targets. EphA2 highly expressed in a variety of human cancers, playing roles in proliferation, m...
SIRT1 promotes glucolipid metabolic conversion to facilitate tumor development in colorectal carcinoma [0.03%]
SIRT1促进葡萄糖向脂质的代谢转化以促进结直肠癌的发生发展
Zhihao Wei,Jianyu Xia,Jiatao Li et al.
Zhihao Wei et al.
Background: Fatty acid oxidation (FAO) is a major alternate energy metabolism pathway in tumor cells subjected to metabolic stress caused by glucose deficiency during rapid progression. However, the mechanism of metabolic reprogramming betw...
M1 Microglia-derived Exosomes Promote Activation of Resting Microglia and Amplifies Proangiogenic Effects through Irf1/miR-155-5p/Socs1 Axis in the Retina [0.03%]
M1小胶质细胞源性外泌体通过Irf1/miR-155-5p/Socs1轴促进视网膜中静息态小胶质细胞活化并放大促血管生成效应
Xi Chen,Xiao Wang,Zedu Cui et al.
Xi Chen et al.
Activation of microglia plays a key role in the development of neovascular retinal diseases. Therefore, it is essential to reveal its pathophysiological and molecular mechanisms to interfere with disease progression. Here a publicly availab...
Novel insights into the interplay between m6A modification and programmed cell death in cancer [0.03%]
m6A修饰与癌症程序性细胞死亡的相互作用的新见解
Jinhao Chen,Mujie Ye,Jianan Bai et al.
Jinhao Chen et al.
N6-methyladenosine (m6A) methylation, the most prevalent and abundant RNA modification in eukaryotes, has recently become a hot research topic. Several studies have indicated that m6A modification is dysregulated during the progression of m...
LncRNA GSCAR promotes glioma stem cell maintenance via stabilizing SOX2 expression [0.03%]
长链非编码RNA GSCAR通过稳定SOX2表达促进胶质瘤干细胞的维持
Xiulin Jiang,Yong Zhang,Yixiao Yuan et al.
Xiulin Jiang et al.
Gliomas are the most aggressive type of malignant brain tumors. Recent studies have demonstrated that the existence of glioma stem cells (GSCs) is critical for glioma recurrence, metastasis, and chemo- or radio-therapy resistance. Temozolom...
Autophagic degradation of LOX-1 is involved in the maintenance of vascular integrity injured by oxLDL and protected by Berberine [0.03%]
氧化低密度脂蛋白损伤血管时，自噬降解LOX-1参与维持血管内皮细胞屏障功能及小檗碱的保护作用机制研究
Yangmin Zheng,Bo Chen,Miaoqing Zhang et al.
Yangmin Zheng et al.
Damage to vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs) caused by oxidized low-density lipoprotein (oxLDL) contributes to cardiovascular and cerebrovascular diseases. Protection effects of Berberine (BBR) on the...
Interaction between dual specificity phosphatase-1 and cullin-1 attenuates alcohol-related liver disease by restoring p62-mediated mitophagy [0.03%]
双重特异性磷酸酶1与Cul1的相互作用通过恢复p62介导的线粒体自噬来缓解酒精相关性肝病
Ruibing Li,Zhe Dai,Xiaoman Liu et al.
Ruibing Li et al.
Besides abstinence, no effective treatment exists for alcohol-related liver disease (ALD), a dreaded consequence of alcohol abuse. In this study, we assessed the roles on ALD of dual specificity phosphatase-1 (DUSP1), an hepatoprotective en...
SB Digestor: a tailored driver gene identification tool for dissecting heterogeneous Sleeping Beauty transposon-induced tumors [0.03%]
SB消化酶：一种用于分析异质性睡眠病原体转座子诱导肿瘤的定制驱动基因识别工具
Aiping Zhang,Lijian Wang,Josh Haipeng Lei et al.
Aiping Zhang et al.
Sleeping Beauty (SB) insertional mutagenesis has been widely used for genome-wide functional screening in mouse models of human cancers, however, intertumor heterogeneity can be a major obstacle in identifying common insertion sites (CISs)....