Hypoxia-activated selectivity-improved anti-PKM2 antibody combined with prodrug TH-302 for potentiated targeting therapy in hepatocellular carcinoma [0.03%]
低氧活化选择性增强的抗PKM2抗体联合前药TH-302用于肝细胞癌的增强靶向治疗
Bo Wang,Fang-Zheng Qi,Ping Chen et al.
Bo Wang et al.
Background: Hypoxia induces hepatocellular carcinoma (HCC) malignancies; yet it also offers treatment opportunities, exemplified by developing hypoxia-activated prodrugs (HAPs). Although HAP TH-302 combined with therapeutic antibody (Ab) ha...
Carbonic Anhydrase 3 is required for cardiac repair post myocardial infarction via Smad7-Smad2/3 signaling pathway [0.03%]
碳酸酐酶3通过Smad7-Smad2/3信号通路对于心肌梗死后的心脏修复是必需的
Yuanyuan Su,Dongmei Shi,Guofang Xia et al.
Yuanyuan Su et al.
Appropriate fibrosis is required to prevent subsequent adverse remodeling and heart failure post myocardial infarction (MI), and cardiac fibroblasts (CFs) play a critical role during the process. Carbonic anhydrase 3 (CAR3) is an important ...
Ubiquitin specific protease 38 aggravates pathological cardiac remodeling by stabilizing phospho-TBK1 [0.03%]
泛素特异性蛋白酶38通过稳定磷酸化TBK1加重心脏病理重构
Zheng Xiao,Chang Dai,Tingting Yu et al.
Zheng Xiao et al.
Chronic pressure overload can cause pathological cardiac remodeling and eventually heart failure. The ubiquitin specific protease (USP) family proteins play a prominent role in regulating substrate protein degradation and cardiac structural...
ALKBH5 facilitates the progression of skin cutaneous melanoma via mediating ABCA1 demethylation and modulating autophagy in an m6A-dependent manner [0.03%]
ALKBH5通过介导ABCA1去甲基化和调节自噬以m6A依赖性方式促进皮肤黑色素瘤的进展
Hanwen Wang,Shixin Zhao,Hengdeng Liu et al.
Hanwen Wang et al.
Background: N6-methyladenosine (m6A) is the most common and abundant mRNA modification, playing an essential role in biological processes and tumor development. However, the role of m6A methylation in skin cutaneous melanoma (SKCM) is not y...
A novel A2a adenosine receptor inhibitor effectively mitigates hepatic fibrosis in a metabolic dysfunction-associated steatohepatitis mouse model [0.03%]
一种新型A2a腺苷受体抑制剂可有效减轻与代谢功能障碍相关的肝脂肪变性小鼠模型中的肝纤维化
Seojeong Park,Seohui Hwang,Jingyang Sun et al.
Seojeong Park et al.
Hepatic fibrosis exacerbates mortality and complications in progressive metabolic dysfunction-associated steatohepatitis (MASH). The role of the adenosine 2A receptor (A2aAR) in hepatic fibrosis within the context of MASH remains uncertain....
Histone lactylation: from tumor lactate metabolism to epigenetic regulation [0.03%]
组蛋白乳酸化：从肿瘤乳酸代谢到表观遗传调控
Xiaoning Yu,Jing Yang,Jin Xu et al.
Xiaoning Yu et al.
The Warburg Effect is one of the most well-known cancer hallmarks. This metabolic pattern centered on lactate has extremely complex effects on various aspects of tumor microenvironment, including metabolic remodeling, immune suppression, ca...
Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects [0.03%]
特异于小管的周期素依赖性激酶12下调通过转录延长缺陷增强肾脏损伤
Yi-Lin Zhang,Tao-Tao Tang,Wei-Jie Ni et al.
Yi-Lin Zhang et al.
Direct tubular injury caused by several medications, especially chemotherapeutic drugs, is a common cause of AKI. Inhibition or loss of cyclin-dependent kinase 12 (CDK12) triggers a transcriptional elongation defect that results in deficien...
The Burgeoning Significance of Liquid-Liquid Phase Separation in the Pathogenesis and Therapeutics of Cancers [0.03%]
液-液相分离在癌症发生和治疗中的重要意义日益凸显
Wei-Xin Xu,Qiang Qu,Hai-Hui Zhuang et al.
Wei-Xin Xu et al.
Liquid-liquid phase separation (LLPS) is a physiological phenomenon that parallels the mixing of oil and water, giving rise to compartments with diverse physical properties. Biomolecular condensates, arising from LLPS, serve as critical reg...
Erratum: Involvement of miR-619-5p in resistance to cisplatin by regulating ATXN3 in oral squamous cell carcinoma: Erratum [0.03%]
错误！微RNA-619-5p通过调节ATXN3参与口腔鳞状细胞癌的顺铂耐药性：勘误表
An Song,Yuanyuan Wu,Weiming Chu et al.
An Song et al.
[This corrects the article DOI: 10.7150/ijbs.54014.]. © The author(s).
The FTO-CMPK2 Pathway in Fibroblast-like Synoviocytes Modulates Rheumatoid Arthritis Synovial Inflammation and Cartilage Homeostasis via mtDNA Regulation [0.03%]
成纤维样滑膜细胞中的FTO-CMPK2途径通过调控mtDNA来调节类风湿性关节炎的滑膜炎症和软骨稳态
Li Jin,Qiyue Chen,Ke Hu et al.
Li Jin et al.
In rheumatoid arthritis (RA), a debilitating autoimmune disorder marked by chronic synovial inflammation and progressive cartilage degradation, fibroblast-like synoviocytes (FLS) are key pathogenic players. Current treatments targeting thes...