BET inhibition induces synthetic lethality in PTEN deficient colorectal cancers via dual action on p21CIP1/WAF1 [0.03%]
PTEN缺陷型结直肠癌中BET抑制通过双重作用于p21cip1/waf1诱导合成致死性
Guowen Ren,Jinghong Chen,Yue Pu et al.
Guowen Ren et al.
Loss of PTEN tumor suppressor is an important event during colorectal cancer (CRC) development and is a target for therapeutic exploitation. This study reports that bromodomain and extra-terminal motif (BET) is a synthetic lethal partner of...
Amino acid transporter SLC7A5 regulates cell proliferation and secretary cell differentiation and distribution in the mouse intestine [0.03%]
肠氨基酸转运蛋白SLC7A5调控小鼠肠道细胞增殖及内分泌细胞分化和分布
Lingyu Bao,Liezhen Fu,Yijun Su et al.
Lingyu Bao et al.
The intestine is critical for not only processing nutrients but also protecting the organism from the environment. These functions are mainly carried out by the epithelium, which is constantly being self-renewed. Many genes and pathways can...
Advancements in technology for characterizing the tumor immune microenvironment [0.03%]
肿瘤免疫微环境特征技术进展
Honglin Yan,Xianli Ju,Aoling Huang et al.
Honglin Yan et al.
Immunotherapy plays a key role in cancer treatment, however, responses are limited to a small number of patients. The biological basis for the success of immunotherapy is the complex interaction between tumor cells and tumor immune microenv...
IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1 [0.03%]
白细胞介素33通过AMPK-ULK1轴介导的自噬溶酶体降解GKN1加速慢性萎缩性胃炎
Kewei Liu,Hongxia Huang,Mengyuan Xiong et al.
Kewei Liu et al.
Chronic atrophic gastritis (CAG) is a complex disease characterized by atrophy and inflammation in gastric mucosal tissue, especially with high expression of interleukins. However, the interaction and mechanisms between interleukins and gas...
CYSLTR1 antagonist inhibits Th17 cell differentiation by regulating the NF-κB signaling for the treatment of psoriasis [0.03%]
CXCR1拮抗剂通过调控NF-κB信号通路抑制Th17细胞分化从而治疗银屑病
Junpeng Zhao,Yi Chen,Liming Li et al.
Junpeng Zhao et al.
Cysteinyl leukotriene receptor 1 (CYSLTR1) is observed to increase in psoriatic skin lesions. Montelukast, a CYSLTR1 antagonist, effectively treats inflammatory disorders, such as rheumatoid arthritis, multiple sclerosis, and atopic dermati...
A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer [0.03%]
乳酸在趋化因子与固有癌症糖酵解交流中的潜在作用研究
Selma Rivas-Fuentes,Teresa Santos-Mendoza,Alfonso Salgado-Aguayo
Selma Rivas-Fuentes
Chemokines are very important for carcinogenesis and the development of a malignant phenotype. Lactate is a small molecule produced during glycolysis; recently it has emerged as an immunomodulator that could impact tumor cell behavior. In t...
PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer [0.03%]
PTPLAD1通过调节PHB-Raf相互作用来调控结直肠癌上皮-间质转化和线粒体融合/分裂转换
Zi-Jia Huang,Yang-Jia Li,Jie Yang et al.
Zi-Jia Huang et al.
Colorectal cancer (CRC) remains one of the leading causes of cancer-related death worldwide. The poor prognosis of this malignancy is attributed mainly to the persistent activation of cancer signaling for metastasis. Here, we showed that pr...
A review on Gaucher disease: therapeutic potential of β-glucocerebrosidase-targeted mRNA/saRNA approach [0.03%]
格肖病研究进展及 glucocerebrosidase 目标mRNA/saRNA治疗潜力探讨
Shunping Feng,Nino Rcheulishvili,Xiaoming Jiang et al.
Shunping Feng et al.
Gaucher disease (GD), a rare hereditary lysosomal storage disorder, occurs due to a deficiency in the enzyme β-glucocerebrosidase (GCase). This deficiency leads to the buildup of substrate glucosylceramide (GlcCer) in macrophages, eventual...
Optogenetic Stimulation of the Cardiac Vagus Nerve to Promote Heart Regenerative Repair after Myocardial Infarction [0.03%]
光遗传学刺激心脏迷走神经促进心肌梗死后的心脏再生修复
Yuan Han,Xiaomin Wei,Guojun Chen et al.
Yuan Han et al.
Background: It had been shown that selective cardiac vagal activation holds great potential for heart regeneration. Optogenetics has clinical translation potential as a novel means of modulating targeted neurons. This study aimed to investi...
Reprogramming of Lipid Metabolism Mediates Crosstalk, Remodeling, and Intervention of Microenvironment Components in Breast Cancer [0.03%]
脂质代谢的重新编程介导乳腺癌微环境成分间的相互交流、重塑及干预
Jia Wang,Wenfeng Zhang,Cun Liu et al.
Jia Wang et al.
Due to the unique characteristics of breast cancer initiation sites and significant alterations in tumor metabolism, breast cancer cells rely on lipid metabolic reprogramming to effectively regulate metabolic programs during the disease pro...