Metabolic Flux Analysis Reveals the Roles of Stearate and Oleate on CPT1C-mediated Tumor Cell Senescence [0.03%]
基于代谢流分析揭示硬脂酸和油酸介导的CPT1C在促进肿瘤细胞衰老中的作用
Panpan Chen,Jingyu Tian,Yanying Zhou et al.
Panpan Chen et al.
Cellular senescence is a state of proliferative arrest, and the development of carcinoma can be suppressed by conferring tumor cell senescence. Recently, we found that carnitine palmitoyltransferase 1C (CPT1C) controls tumor cell proliferat...
Chronic stress promotes colorectal cancer progression by enhancing glycolysis through β2-AR/CREB1 signal pathway [0.03%]
慢性应激通过β2-肾上腺素能受体/ CREB1信号通路促进结直肠癌进展：一项机制研究
Yunfeng Guan,Wang Yao,Hao Yu et al.
Yunfeng Guan et al.
Colorectal cancer (CRC) is a common malignancy worldwide, and chronic stress has been considered as a significant risk factor for CRC. However, the role of chronic stress in CRC progression is unclear. The present study showed that pre-expo...
PI3K/ c-Myc/AFF4 axis promotes pancreatic tumorigenesis through fueling nucleotide metabolism [0.03%]
PI3K/c-Myc/AFF4轴通过促进核苷酸代谢来推动胰腺肿瘤发生发展
Chenming Ni,Wenyu Liu,Kailian Zheng et al.
Chenming Ni et al.
MLL-AFF4 fusion gene has been discovered in acute leukemia, whether AFF4 alone plays a role in tumor, especially pancreatic tumorigenesis, is still elusive. Increasing evidence suggests that cancer cells altered nucleotide metabolism during...
Tianyuan Xu,Zhong Zheng,Weili Zhao
Tianyuan Xu
Follicular lymphoma (FL) is the most common indolent lymphoma originating from germinal center B cells. FL represents a clinically and biologically heterogeneous disease. Most patients have favorable outcomes, but a subset of patients exper...
Myeloid-specific blockade of Notch signaling ameliorates nonalcoholic fatty liver disease in mice [0.03%]
小胶质细胞特异性阻断诺特定点信号改善小鼠非酒精性脂肪肝病
Jian Ding,Ming Xu,Wei Du et al.
Jian Ding et al.
Rationale: Macrophages play a central role in the development and progression of nonalcoholic fatty liver disease (NAFLD). Studies have shown that Notch signaling mediated by transcription factor recombination signal binding protein for imm...
Loss of HRD functional phenotype impedes immunotherapy and can be reversed by HDAC inhibitor in ovarian cancer [0.03%]
HRD功能表型的丢失阻碍了免疫治疗并可以被HDAC抑制剂逆转卵巢癌
Dong Yang,Fu-Xue Huang,Wei Wei et al.
Dong Yang et al.
In recent years, homologous recombination deficiency (HRD) has not achieved the expected substantial promotion of immunotherapeutic efficacy in ovarian cancer. This study aims to explore the role of HRD functional phenotype as a powerful bi...
NLRP3 Inflammasome Mediates Silica-induced Lung Epithelial Injury and Aberrant Regeneration in Lung Stem/Progenitor Cell-derived Organotypic Models [0.03%]
NLRP3炎性小体介导的二氧化硅致肺上皮损伤及干细胞源器官型模型中的异常再生反应
Hong Zhou,Qun Zhang,Wen Huang et al.
Hong Zhou et al.
Silica-induced lung epithelial injury and fibrosis are vital pathogeneses of silicosis. Although the NOD-like receptor protein 3 (NLRP3) inflammasome contributes to silica-induced chronic lung inflammation, its role in epithelial injury and...
Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer [0.03%]
化学蛋白质组学鉴定出过氧化氢酶1作为三阴性乳腺癌的潜在治疗靶点
Elena Spínola-Lasso,Juan Carlos Montero,Roberto Jiménez-Monzón et al.
Elena Spínola-Lasso et al.
Triple-negative breast cancer (TNBC) is difficult to treat; therefore, the development of drugs directed against its oncogenic vulnerabilities is a desirable goal. Herein, we report the antitumor effects of CM728, a novel quinone-fused oxaz...
SCF/c-Kit-activated signaling and angiogenesis require Gαi1 and Gαi3 [0.03%]
SCF/c-Kit激活的信号转导和新生血管形成需要Gαi1和Gαi3
Hua-Jian Shan,Kun Jiang,Ming-Zhi Zhao et al.
Hua-Jian Shan et al.
The stem cell factor (SCF) binds to c-Kit in endothelial cells, thus activating downstream signaling and angiogenesis. Herein, we examined the role of G protein subunit alpha inhibitory (Gαi) proteins in this process. In MEFs and HUVECs, G...
BAP31 depletion inhibited adipogenesis, repressed lipolysis and promoted lipid droplets abnormal growth via attenuating Perilipin1 proteasomal degradation [0.03%]
BAP31缺失抑制脂肪细胞分化、抑制脂解并促进异常脂滴生成：通过减少Perilipin1的泛素-蛋白酶体降解实现
Xueying Wei,Liya Li,Jie Zhao et al.
Xueying Wei et al.
BAP31 expression was robustly decreased in obese white adipose tissue (WAT). To investigate the roles of BAP31 in lipid metabolism, adipocyte-specific conditional knockout mice (BAP31-ASKO) were generated. BAP31-ASKO mice grow normally as c...