TAZ deficiency impairs the autophagy-lysosomal pathway through NRF2 dysregulation and lysosomal dysfunction [0.03%]
TAZ缺陷通过NRF2失调和溶酶体功能障碍损害自噬-溶酶体途径
Hyo Kyeong Kim,Hana Jeong,Mi Gyeong Jeong et al.
Hyo Kyeong Kim et al.
Transcriptional coactivator with a PDZ-binding motif (TAZ) plays a key role in normal tissue homeostasis and tumorigenesis through interaction with several transcription factors. In particular, TAZ deficiency causes abnormal alveolarization...
Paris saponin VII reverses resistance to PARP inhibitors by regulating ovarian cancer tumor angiogenesis and glycolysis through the RORα/ECM1/VEGFR2 signaling axis [0.03%]
Paris saponin Ⅶ通过RORα/ECM1/VEGFR2信号轴调控卵巢癌肿瘤血管生成和糖酵解逆转PARP抑制剂耐药性
Mengfei Wang,Chenyue Yuan,Zong Wu et al.
Mengfei Wang et al.
The emergence of Poly (ADP-ribose) polymerase inhibitors (PARPi) has marked the beginning of a precise targeted therapy era for ovarian cancer. However, an increasing number of patients are experiencing primary or acquired resistance to PAR...
Uncovering a Novel Functional Interaction Between Adult Hepatic Progenitor Cells, Inflammation and EGFR Signaling During Bile Acids-Induced Injury [0.03%]
胆汁酸诱导损伤时肝 progenitors细胞、炎症和EGFR信号间的新功能相互作用的揭示
Juan García-Sáez,María Figueroa-Fuentes,Carlos González-Corralejo et al.
Juan García-Sáez et al.
Chronic cholestatic damage is associated to both accumulation of cytotoxic levels of bile acids and expansion of adult hepatic progenitor cells (HPC) as part of the ductular reaction contributing to the regenerative response. Here, we repor...
E3 ubiquitin ligase BCA2 promotes breast cancer stemness by up-regulation of SOX9 by LPS [0.03%]
LPS通过上调SOX9促进乳腺癌干细胞特性的E3泛素连接酶BCA2
Min Zheng,Wenjing Liu,Rou Zhang et al.
Min Zheng et al.
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer. Breast cancer stem cells (BCSCs) are believed to play a crucial role in the carcinogenesis, therapy resistance, and metastasis of TNBC. It is well known th...
Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy [0.03%]
FADDosome诱导的线粒体功能障碍促进门脉高压性胃病的黏膜损伤
Yuelin Xiao,Yiwang Zhang,Kaiduan Xie et al.
Yuelin Xiao et al.
Mucosal epithelial death is an essential pathological characteristic of portal hypertensive gastropathy (PHG). FADDosome can regulate mucosal homeostasis by controlling mitochondrial status and cell death. However, it remains ill-defined wh...
The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation [0.03%]
褪黑素通过N6-腺苷甲基化（m6A）调节脂多糖诱导的结肠炎症的作用机制研究
Yuanyuan Li,Baochen Ma,Zixu Wang et al.
Yuanyuan Li et al.
Colon inflammation is characterized by disturbances in the intestinal microbiota and inflammation. Melatonin (Mel) can improve colon inflammation. However, the underlying mechanism remains unclear. Recent studies suggest that m6A methylatio...
Seleno-amino Acid Metabolism Reshapes the Tumor Microenvironment: from Cytotoxicity to Immunotherapy [0.03%]
硒代氨基酸代谢重塑肿瘤微环境：从细胞毒性到免疫治疗
Rui Liang,Aoyu Cheng,Shengxin Lu et al.
Rui Liang et al.
Selenium (Se) is an essential trace element for biological processes. Seleno-amino acids (Se-AAs), known as the organic forms of Se, and their metabolic reprogramming have been increasingly recognized to regulate antioxidant defense, enzyme...
Ciliogenesis-associated Kinase 1 Promotes Breast Cancer Cell Proliferation and Chemoresistance via Phosphorylating ERK1 [0.03%]
丝状伪足生成相关激酶1通过磷酸化ERK1促进乳腺癌细胞增殖和化疗耐药性
Yanling He,Xinyuan Zhang,Weijun Pan et al.
Yanling He et al.
Ciliogenesis-associated kinase 1 (CILK1) plays a key role in the ciliogenesis and ciliopathies. It remains totally unclear whether CILK1 is involved in tumor progression and therapy resistance. Here, we report that the aberrant high-express...
Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, Pharmacological Modulation, and Lifestyle Medicine [0.03%]
(proper)情境下的自噬：分子基础、生物学相关性、药理学调控和生活方式医学
Miguel A Ortega,Oscar Fraile-Martinez,Diego de Leon-Oliva et al.
Miguel A Ortega et al.
Autophagy plays a critical role in maintaining cellular homeostasis and responding to various stress conditions by the degradation of intracellular components. In this narrative review, we provide a comprehensive overview of autophagy's cel...
Neuropeptide substance P attenuates colitis by suppressing inflammation and ferroptosis via the cGAS-STING signaling pathway [0.03%]
神经肽物质P通过cGAS-STING信号通路抑制炎症和铁死亡从而缓解结肠炎
Jing Lan,Ziteng Deng,Qiuzhen Wang et al.
Jing Lan et al.
Neuropeptide substance P (SP) belongs to a family of bioactive peptides and regulates many human diseases. This study aims to investigate the role and underlying mechanisms of SP in colitis. Here, activated SP-positive neurons and increased...