Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications [0.03%]
花青素作为呼吸系统疾病的治疗药物：从临床前证据到潜在的临床应用
Talha Bin Emran,Taslima Akter Eva,Mehrukh Zehravi et al.
Talha Bin Emran et al.
Respiratory diseases are the most common and severe health complication and a leading cause of death worldwide. Despite breakthroughs in diagnosis and treatment, few safe and effective therapeutics have been reported. Phytochemicals are gai...
m6A RNA methylation drives kidney fibrosis by upregulating β-catenin signaling [0.03%]
M6A RNA甲基化通过上调β-catenin信号驱动肾纤维化
Yinyi Long,Dongyan Song,Liuyan Xiao et al.
Yinyi Long et al.
N6-methyladenosine (m6A) methylation plays a crucial role in various biological processes and the pathogenesis of human diseases. However, its role and mechanism in kidney fibrosis remain elusive. In this study, we show that the overall lev...
Haikun Lin,Chentao Li,Wanying Zhang et al.
Haikun Lin et al.
Cellular immunotherapy has emerged as an exciting strategy for cancer treatment, as it aims to enhance the body's immune response to tumor cells by engineering immune cells and designing synthetic molecules from scratch. Because of the cyto...
Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation [0.03%]
由POLG突变诱发的线粒体功能障碍激活神经毒性星形胶质细胞
Kristina Xiao Liang,Anbin Chen,Atefeh Kianian et al.
Kristina Xiao Liang et al.
Mitochondrial diseases are associated with neuronal death and mtDNA depletion. Astrocytes respond to injury or stimuli and damage to the central nervous system. Neurodegeneration can cause astrocytes to activate and acquire toxic functions ...
Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated Autophagosome Formation [0.03%]
金属硫蛋白3通过促进锌-MTF1-ATG5轴介导的自噬体形成增强肺动脉平滑肌细胞增殖
Tianxin Xiong,Yi Li,Molin Yang et al.
Tianxin Xiong et al.
Abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) is one of the critical pathological mechanisms of pulmonary hypertension (PH), and therefore is gradually being adopted as an important direction for the treatment of P...
Nanoenabled intracellular zinc bursting for efficacious reversal of gefitinib resistance in lung cancer [0.03%]
基于纳米技术的细胞内锌爆发高效逆转非小细胞肺癌吉非替尼耐药性机制研究
Junnan Li,Yehuda G Assaraf,Weimin Zuo et al.
Junnan Li et al.
Following the identification of specific epidermal growth factor receptor (EGFR)-activating mutations, gefitinib, one of the first-generation tyrosine kinase inhibitors (TKIs), has proven efficacious in targeting NSCLC that is driven by spe...
Sodium chloride promotes macrophage pyroptosis and aggravates rheumatoid arthritis by activating SGK1 through GABA receptors Slc6a12 [0.03%]
氯化钠通过GABA受体Slc6a12促进SGK1活化从而诱导巨噬细胞焦亡并加重类风湿性关节炎
Xianzheng Zhang,Ziwei Zhang,Yuchen Zhao et al.
Xianzheng Zhang et al.
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and the production of autoantibodies. Previous studies have indicated an association between high-salt diets (HSD) and an increased ri...
Unlocking the Nexus of Sirtuins: A Comprehensive Review of Their Role in Skeletal Muscle Metabolism, Development, and Disorders [0.03%]
揭秘sirtuins功能网络：其在骨骼肌代谢、发育及疾病中的作用综述
Bahareldin Ali Abdalla Gibril,Xinwei Xiong,Xuewen Chai et al.
Bahareldin Ali Abdalla Gibril et al.
The sirtuins constitute a group of histone deacetylases reliant on NAD+ for their activity that have gained recognition for their critical roles as regulators of numerous biological processes. These enzymes have various functions in skeleta...
Danna Yeerken,Wenchang Xiao,Jia Li et al.
Danna Yeerken et al.
The mechanism that maintains ER-to-Golgi vesicles formation and transport is complicated. As one of the adapters, Ninein-like protein (Nlp) participated in assembly and transporting of partial ER-to-Golgi vesicles that contained specific pr...
HDAC Inhibition Sensitize Hepatocellular Carcinoma to Lenvatinib via Suppressing AKT Activation [0.03%]
组蛋白去乙酰化酶抑制剂通过抑制AKT磷酸化增强肝细胞癌对仑伐替尼敏感性
Shuai Yan,Lu Chen,Hao Zhuang et al.
Shuai Yan et al.
Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options. As a first-line treatment for advanced HCC, Lenvatinib has been applicated in clinic since 2018. Resistance to Lenvatinib, however, has severely restricte...