Jiayan Fu,Haiyang Dong,Jian Wu et al.
Jiayan Fu et al.
RNA-based therapeutics (e.g., mRNAs, siRNAs, microRNAs, ASOs, and saRNAs) have considerable potential for tumor treatment. The development and optimization of RNA modifications and delivery systems enable the stable and efficient delivery o...
Loss of MIR503HG facilitates papillary renal cell carcinoma associated lymphatic metastasis by triggering NOTCH1/VEGFC signaling [0.03%]
MIR503HG丢失通过触发NOTCH1 / VEGFC信号促进乳头状肾细胞癌相关的淋巴管转移
Yiqiu Wang,Xinyi Zheng,Wenjie Huang et al.
Yiqiu Wang et al.
Clinical lymphatic metastasis indicates an extremely poor prognosis. Patients with papillary renal cell carcinoma (pRCC) have a high probability of progressing to lymphatic metastasis. However, the molecular mechanism of pRCC-associated lym...
Erratum: CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways: Erratum [0.03%]
Correction: CXCL16通过ADAM10依赖的CXCL16/CXCR6轴促进胃癌肿瘤发生并激活Akt和MAPK信号通路: 纠错通知
Jing Han,Runjia Fu,Cong Chen et al.
Jing Han et al.
[This corrects the article DOI: 10.7150/ijbs.57826.]. © The author(s).
Dendropanoxide Alleviates Thioacetamide-induced Hepatic Fibrosis via Inhibition of ROS Production and Inflammation in BALB/C Mice [0.03%]
忍冬素通过抑制活性氧生成和炎症反应缓解BALB/c小鼠肝纤维化作用机制研究
Amit Kundu,Sreevarsha Gali,Swati Sharma et al.
Amit Kundu et al.
Hepatic fibrosis results from overproduction and excessive accumulation of extracellular matrix (ECM) proteins in hepatocytes. Although the beneficial effects of dendropanoxide (DPx) isolated from Dendropanax morbifera have been studied, it...
Li Li,Fang-Rong Shen,Qunxian Cheng et al.
Li Li et al.
Novel molecular targets for cervical cancer must be identified. This study examined the role of SLC5A3, a myo-inositol transporter, in the pathogenesis of cervical cancer. Through boinformatics analysis, we showed that the SLC5A3 mRNA level...
Liver X receptors and estrogen receptor β, two players in a rare subtype of NSCLC [0.03%]
肝X受体和雌激素受体β在一种罕见的NSCLC亚型中发挥作用
Wanfu Wu,Mozhgan Sarhadi,Xiaoyu Song et al.
Wanfu Wu et al.
Liver X receptors (LXRαβ) play essential roles in the maintenance of the normal functions of macrophages, in modulation of immune system responses and cholesterol homeostasis. We have reported that LXRαβ-/- mice develop squamous cell lu...
TLR9 and STING agonists cooperatively boost the immune response to SARS-CoV-2 RBD vaccine through an increased germinal center B cell response and reshaped T helper responses [0.03%]
TLR9和STING激动剂通过增加生发中心B细胞反应和重塑T辅助细胞反应来协同增强对SARS-CoV-2 RBD疫苗的免疫响应
Jing-Xing Yang,Jen-Chih Tseng,Chih-Feng Tien et al.
Jing-Xing Yang et al.
Vaccines are a powerful medical intervention for preventing epidemic diseases. Efficient inactivated or protein vaccines typically rely on an effective adjuvant to elicit an immune response and boost vaccine activity. In this study, we inve...
Melatonin modulates the hypothalamic-pituitary neuroendocrine axis to regulate physiological color change in teleost fish [0.03%]
褪黑素通过调节鱼类下丘脑-垂体神经内分泌轴调控鱼类生理性变色反应
Jiaqian Feng,Jingwen Yang,Zhijing Jiang et al.
Jiaqian Feng et al.
Melatonin (MT) is a crucial neuroendocrine regulator of various physiological activities in vertebrates, especially in circadian or seasonal rhythm control. In the present study, the large yellow croaker (Larimichthys crocea), a marine bony...
Induction of Immune Responses and Phosphatidylserine Exposure by TLR9 Activation Results in a Cooperative Antitumor Effect with a Phosphatidylserine-targeting Prodrug [0.03%]
TLR9激活诱导的免疫反应和磷脂酰丝氨酸表达与靶向磷脂酰丝氨酸前药的抗肿瘤作用之间的协同效应研究
Jen-Chih Tseng,Jing-Xing Yang,Chia-Yin Lee et al.
Jen-Chih Tseng et al.
Head and neck cancer is a major cancer type, with high motility rates that reduce the quality of life of patients. Herein, we investigated the effectiveness and mechanism of a combination therapy involving TLR9 activator (CpG-2722) and phos...
Synergism of FAK and ROS1 inhibitors in the treatment of CDH1-deficient cancers mediated by FAK-YAP signaling [0.03%]
FAK和ROS1抑制剂在CDH1缺陷型癌症治疗中的协同作用机制研究：通过FAK-YAP信号通路介导
Jiaming Gao,Yunying Yao,Chenxuan Liu et al.
Jiaming Gao et al.
CDH1 deficiency is common in diffuse gastric cancer and triple negative breast cancer patients, both of which still lack effective therapeutics. ROS1 inhibition results in synthetic lethality in CDH1-deficient cancers, but often leads to ad...