PTBP1-mediated biogenesis of circATIC promotes progression and cisplatin resistance of bladder cancer [0.03%]
PTBP1介导的circATIC生物发生促进膀胱癌的发生发展及其顺铂耐药性
Chenchen Huang,Yang Yang,Xiaofei Wang et al.
Chenchen Huang et al.
Background: Cisplatin (DDP) based combination chemotherapy is a vital method for the treatment of bladder cancer (BLca). Chemoresistance easily occurs in the course of cisplatin chemotherapy, which is one of the important reasons for the un...
Ursolic Acid Alleviates Mitotic Catastrophe in Podocyte by Inhibiting Autophagic P62 Accumulation in Diabetic Nephropathy [0.03%]
乌索酸通过抑制自噬性p62累积来缓解糖尿病肾病中足细胞有丝分裂灾难效应
Hang Mei,Tienan Jing,Haojun Liu et al.
Hang Mei et al.
The glomerular podocyte, a terminally differentiated cell, is crucial for the integrity of the glomerular filtration barrier. The re-entry of podocytes into the mitotic phase results in injuries or death, known as mitotic catastrophe (MC), ...
Negative Regulation of CPSF6 Suppresses the Warburg Effect and Angiogenesis Leading to Tumor Progression Via c-Myc Signaling Network: Potential Therapeutic Target for Liver Cancer Therapy [0.03%]
CPSF6负向调控通过c-Myc信号网络抑制瓦博格效应和血管生成从而抑制肿瘤发生发展：肝癌治疗的潜在靶点
Deok Yong Sim,Hyo-Jung Lee,Chi-Hoon Ahn et al.
Deok Yong Sim et al.
In this study, we explored the oncogenic mechanism of cleavage and polyadenylation-specific factor 6 (CPSF6) in hepatocellular carcinoma (HCC). CPSF6 was overexpressed in HCC tissues with poor survival rates compared to normal tissues. Henc...
Cigarette smoke promotes IL-6-dependent lung cancer migration and osteolytic bone metastasis [0.03%]
吸烟通过IL-6促进肺癌转移和溶骨性骨转移
Jeng-Hung Guo,Le Huynh Hoai Thuong,Ya-Jing Jiang et al.
Jeng-Hung Guo et al.
Lung cancer stands as a major contributor to cancer-related fatalities globally, with cigarette smoke playing a pivotal role in its development and metastasis. Cigarette smoke is also recognized as a risk factor for bone loss disorders like...
Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma [0.03%]
去泛素化酶USP14介导的CIB1去泛素化通过PAK1-ERK1/2轴促进肝细胞癌获得仑伐替尼耐药性
Ming-Hao Xu,Yi-Min Zheng,Bu-Gang Liang et al.
Ming-Hao Xu et al.
Background: Lenvatinib is the most common multitarget receptor tyrosine kinase inhibitor for the treatment of advanced hepatocellular carcinoma (HCC). Acquired resistance to lenvatinib is one of the major factors leading to the failure of H...
Epsti1 Regulates the Inflammatory Stage of Early Muscle Regeneration through STAT1-VCP Interaction [0.03%]
Epsti1通过STAT1-VCP相互作用调节早期肌肉再生的炎症阶段
Jee Won Kim,Ju-Hyeon Bae,Ga-Yeon Go et al.
Jee Won Kim et al.
During muscle regeneration, interferon-gamma (IFN-γ) coordinates inflammatory responses critical for activation of quiescent muscle stem cells upon injury via the Janus kinase (JAK) - signal transducer and activator of transcription 1 (STA...
IFNAR(-/-) Mice Constitute a Suitable Animal Model for Epizootic Hemorrhagic Disease Virus Study and Vaccine Evaluation [0.03%]
IFNAR(-/-)小鼠可作为兔出血症病毒研究和疫苗评价的动物模型
Luis Jiménez-Cabello,Sergio Utrilla-Trigo,Julio Benavides-Silván et al.
Luis Jiménez-Cabello et al.
Epizootic hemorrhagic disease (EHD), caused by Epizootic hemorrhagic disease virus (EHDV), is an emerging and severe livestock disease. Recent incursion and distribution of EHDV in Europe have outlined the emerging character of EHD. Despite...
Endothelial Dickkopf-1 Promotes Smooth Muscle Cell-derived Foam Cell Formation via USP53-mediated Deubiquitination of SR-A During Atherosclerosis [0.03%]
内皮细胞来源的DKK1通过USP53介导的SR-A去泛素化促进动脉粥样硬化中平滑肌细胞源泡沫细胞形成
Xiaolin Liu,Tengfei Zheng,Yu Zhang et al.
Xiaolin Liu et al.
Background: Shear stress-induced Dickkopf-1 (DKK1) secretion by endothelial cells (ECs) promotes EC dysfunction and accelerates atherosclerosis (AS). However, the paracrine role of endothelial DKK1 in modulating adjacent smooth muscle cells...
CYR61 Acts as an Intracellular Microtubule-Associated Protein and Coordinates Mitotic Progression via PLK1-FBW7 Pathway [0.03%]
Cyr61充当一种胞内微管相关蛋白并通过PLK1-FBW7通路协调有丝分裂进程
Kaishun Hu,Limin Xie,Wenjing Wu et al.
Kaishun Hu et al.
Cysteine-rich angiogenic inducer 61 (CYR61), also called CCN1, has long been characterized as a secretory protein. Nevertheless, the intracellular function of CYR61 remains unclear. Here, we found that CYR61 is important for proper cell cyc...
Myeloid cell-expressed MNDA enhances M2 polarization to facilitate the metastasis of hepatocellular carcinoma [0.03%]
髓系细胞表达的MNDA通过促进肝癌转移中的M2极化发挥作用
Yanru Meng,Mengxin Zhang,Xinli Li et al.
Yanru Meng et al.
Stable infiltration of myeloid cells, especially tumor-associated M2 macrophages, acts as one of the essential features of the tumor immune microenvironment by promoting the malignant progression of hepatocellular carcinoma (HCC). However, ...