Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice [0.03%]
Nibp/Trappc9缺陷斑马鱼和小鼠的神经突起伸长及分支异常
Min Hu,Brittany Bodnar,Yonggang Zhang et al.
Min Hu et al.
Loss of function in transport protein particles (TRAPP) links a new set of emerging genetic disorders called "TRAPPopathies". One such disorder is NIBP syndrome, characterized by microcephaly and intellectual disability, and caused by mutat...
Erratum: A positive feedback loop of CENPU/E2F6/E2F1 facilitates proliferation and metastasis via ubiquitination of E2F6 in hepatocellular carcinoma: Erratum [0.03%]
CENPU/E2F6/E2F1正反馈环通过E2F6泛素化促进肝癌增殖和转移：勘误通知
Yingyi Liu,Ye Yao,Bo Liao et al.
Yingyi Liu et al.
[This corrects the article DOI: 10.7150/ijbs.69495.]. © The author(s).
FABP5 suppresses colorectal cancer progression via mTOR-mediated autophagy by decreasing FASN expression [0.03%]
脂肪酸结合蛋白5通过降低乙酰辅酶A羧化酶的表达诱导线粒体自噬抑制结直肠癌进展
Mujie Ye,Chunhua Hu,Tiaotiao Chen et al.
Mujie Ye et al.
Lipid metabolism plays an important role in the occurrence and development of cancer, in particular, digestive system tumors such as colon cancer. Here, we investigated the role of the fatty acid-binding protein 5 (FABP5) in colorectal canc...
VDAC2 malonylation participates in sepsis-induced myocardial dysfunction via mitochondrial-related ferroptosis [0.03%]
丝裂霉素相关铁死亡介导的脓毒症心肌功能障碍中的VDAC2琥珀化作用
Han She,Lei Tan,Yuanlin Du et al.
Han She et al.
Sepsis-induced myocardial dysfunction (SIMD) is a prevalent and severe form of organ dysfunction with elusive underlying mechanisms and limited treatment options. In this study, the cecal ligation and puncture and lipopolysaccharide (LPS) w...
Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer Treatment [0.03%]
天然的Nrf2抑制剂：对癌症治疗潜力的研究综述
Juan Zhang,Hong-Xi Xu,Jia-Qian Zhu et al.
Juan Zhang et al.
Nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that regulates redox homeostasis, plays a pivotal role in several cellular processes such as cell proliferation and survival, and has been found to be aberrantly act...
β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's disease [0.03%]
老年痴呆病程中β-淀粉样蛋白与巨噬细胞模式识别受体Dectin-1结合引起炎症反应
Xia Zhao,Jinfeng Sun,Li Xiong et al.
Xia Zhao et al.
Microglia-mediated neuroinflammation is closely related to the development of Alzheimer's disease (AD). In the early stages of the inflammation response, pattern recognition receptors (PRRs) play a key role in clearing damaged cells and def...
Inhibition of KMO Ameliorates Myocardial Ischemia Injury via Maintaining Mitochondrial Fusion and Fission Balance [0.03%]
KMO抑制通过维持线粒体融合和分裂平衡来改善心肌缺血损伤
Qiong Lai,Lingling Wu,Shuhong Dong et al.
Qiong Lai et al.
Looking for early diagnostic markers and therapeutic targets is the key to ensuring prompt treatment of myocardial ischemia (MI). Here, a novel biomarker xanthurenic acid (XA) was identified based on metabolomics and exhibited high sensitiv...
Nicotinamide adenine dinucleotide kinase promotes lymph node metastasis of NSCLC via activating ID1 expression through BMP pathway [0.03%]
烟酰胺腺嘌呤二核苷酸激酶通过BMP信号调控ID1表达从而促进非小细胞肺癌淋巴结转移
Zimei Zeng,Jie Gao,Tao Chen et al.
Zimei Zeng et al.
Metastasis is a significant cause of high mortality in lung cancer. Lymph node (LN) metastasis is the most common metastatic pathway in non-small cell lung cancer and the most crucial factor affecting the prognosis of NSCLC. Nevertheless, t...
A Novel Isotope-labeled Small Molecule Probe CC12 for Anti-glioma via Suppressing LYN-mediated Progression and Activating Apoptosis Pathways [0.03%]
一种新型同位素标记的小分子探针CC12通过抑制LYN介导的进程并激活凋亡途径来抗胶质瘤
Hsu-Shan Huang,I-Tsang Chiang,Bashir Lawal et al.
Hsu-Shan Huang et al.
Background: Glioblastoma multiforme (GBM) is the most lethal malignancy in brain, which is surrounded by the blood-brain barrier (BBB), which limits the efficacy of standard treatments. Developing an effective drug that can penetrate the bl...
SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer [0.03%]
SDPR通过调节脂肪酸氧化抑制TGF-β诱导的胃癌转移
Xiaoyue Li,Jing Luo,Kelin Mou et al.
Xiaoyue Li et al.
Our previous studies have confirmed that transforming growth factor-β (TGF-β) plays an important role in tumor metastasis, and the serum deprivation protein response (SDPR) is a potential downstream target of TGF-β. However, the role and...