Heparanase 2 (Hpa2) protects the exocrine pancreas from damages of Western diet and pancreatic cancer [0.03%]
肝硫酸酯酶2（Hpa2）保护外分泌胰腺免受西方饮食和胰腺癌的损害
Yasmin Kayal,Malik Farhoud,Maali Odeh et al.
Yasmin Kayal et al.
Fatty pancreas and pancreatitis are increasingly linked to Western dietary patterns and pancreatic cancer risk, yet intrinsic molecular mechanisms that preserve pancreatic identity under metabolic stress remain insufficiently defined. Hepar...
Reprogramming Transcriptional Networks via CREB1 Lactylation at K122 Activates HMGB1-Mediated NETosis and Chemoresistance [0.03%]
CREB1-K122乳酰化介导的转录网络重编程激活HMGB1促进NETosis及肿瘤化疗耐药
Jia-Mei Wang,Fu-Ying Zhao,Qi Zhang et al.
Jia-Mei Wang et al.
Cisplatin resistance remains a major obstacle in ovarian cancer treatment. While lactate-rich tumor microenvironments promote chemoresistance, the role of lysine lactylation (Kla) in this process remains poorly understood. Here, we identify...
B3GNT6-Linked Multimodal Signatures Integrate Tissue Morphology and PTM-Related Transcriptomics to Stratify Tumor [0.03%]
基于B3GNT6的多模态分子特征整合组织形态及翻译后修饰相关转录组数据对肿瘤进行分层分析
Kun Mei,Yipeng Xu,Renjun Gu et al.
Kun Mei et al.
Colon adenocarcinoma (COAD) exhibits substantial molecular and microenvironmental heterogeneity, limiting the reliability and clinical application of single-omics biomarkers. Post-translational modifications (PTMs) play a pivotal role in co...
CXCL6 exacerbates metabolic dysfunction-associated steatohepatitis by suppressing LPIN1-mediated fatty acid oxidation in hepatocytes [0.03%]
CXCL6通过抑制肝细胞中的LPIN1介导的脂肪酸氧化来加重与代谢功能障碍相关的steatohepatitis
Ye Eun Cho,Min-Ju Kim,Yeonsoo Kim et al.
Ye Eun Cho et al.
Progression of hepatic steatosis to metabolic dysfunction-associated steatohepatitis (MASH) is driven by impaired fatty acid (FA) oxidation and subsequent hepatocyte lipotoxicity. While MASH is characterized by upregulation of the neutrophi...
SIRT3 activation by oroxylin A phosphate diethyl ester triggers mitochondrial dysfunction and apoptosis in non-small cell lung cancer [0.03%]
黄芩素磷酸二乙酯通过激活SIRT3诱导非小细胞肺癌的线粒体功能障碍和凋亡
Chiang-Wen Lee,Yu-Feng Lin,Kuan-Han Lee et al.
Chiang-Wen Lee et al.
Lung cancer remains the leading cause of cancer mortality worldwide, and outcomes for advanced non-small cell lung cancer (NSCLC) are limited by resistance and toxicity. Sirtuin 3 (SIRT3), a mitochondrial NAD+-dependent deacetylase, regulat...
The MCU-MECOM Axis Orchestrates Glioblastoma Progression by Remodeling Mitochondrial Dynamics and Quality Control via MAMs [0.03%]
MCU-MECOM轴通过MAM重塑线粒体动力学和质量控制来促进胶质母细胞瘤进展
Xiaodong Li,Yaoliang Wang,Feifei Wu et al.
Xiaodong Li et al.
Glioblastoma (GBM) exhibits metabolic plasticity, relying on mitochondrial oxidative phosphorylation (OXPHOS) to support migration and therapy resistance. Although mitochondrial calcium overload typically induces apoptosis, GBM cells mainta...
Redirecting Cholesterol Metabolism During Ex Vivo Biomanufacturing Enhances the Metabolic Fitness and Antitumor Efficacy of CAR-T Cells [0.03%]
在体外生物制造过程中重新定向胆固醇代谢可增强CAR-T细胞的代谢适应性和抗肿瘤效力
Yuge Zhu,Jiaxin Tu,Shuang Li et al.
Yuge Zhu et al.
Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized the treatment of hematologic malignancies; however, its efficacy in solid tumors remains limited, partly due to T cell exhaustion during ex vivo manufacturing. Emerging evi...
Targeting Tumor-Associated Macrophages to Reshape the Immuno-Mechanical Landscape: Molecular Mechanisms and Therapeutic Strategies [0.03%]
靶向肿瘤相关巨噬细胞重塑免疫力学微环境：分子机制与治疗策略
Guanghui Liu,Yang Yu,Zichen Guo et al.
Guanghui Liu et al.
The progression and therapeutic resistance of solid tumors are profoundly influenced by the mechanical microenvironment, in which extracellular matrix stiffening, elevated interstitial pressure, and aberrant mechanotransductive signaling co...
Huaier Polysaccharides Sensitize Anti-PD-L1 Therapy via Promoting Antitumor Immune Response in Triple-Negative Breast Cancer [0.03%]
华而不药多糖通过促进抗肿瘤免疫反应增强抗PD-L1疗法在三阴性乳腺癌中的敏感性
Lin-Xi Zhou,Zi-Wei Wu,Yuan Tian et al.
Lin-Xi Zhou et al.
Triple-negative breast cancer (TNBC) is characterized by its aggressiveness and resistance to conventional therapies. Although immune checkpoint inhibitors (ICIs) have shown promise in cancer treatment, TNBC patients respond suboptimally to...
A Scorpion Venom-Derived Peptide M6 Endowed with Anti-Aging Ability via Enhanced Antioxidant Activity in Cells, Caenorhabditis elegans and Mouse Models [0.03%]
一种增强细胞、秀丽隐杆线虫和小鼠抗氧化活性的抗衰老蝎毒肽M6
Siyuan Luo,Haixin Qin,Weimin Zuo et al.
Siyuan Luo et al.
With an aging population and the prevalence of oxidative damage-related ailments, the quest for effective antioxidant and anti-aging agents has emerged as a focal point of biomedical research. Within this domain, peptides have garnered cons...