Kaixiang Liu,Min Yu,Yangyang He et al.
Kaixiang Liu et al.
TGF-β/Smad3 signaling is a key pathway leading to the cell death and renal fibrosis. Here we report a new mechanism through which Smad3 mediates renal fibrosis by downregulating the glutathione peroxidase 4 (GPX4), a central inhibitor for ...
Metabolic Syndrome-Associated Erectile Dysfunction: Multiple Vascular Endothelial Dysfunction Mechanisms and Potential Therapeutic Targets [0.03%]
代谢综合征相关性勃起功能障碍：多种血管内皮功能紊乱机制及潜在治疗靶点
Hao Wang,Jun Guo,Eric Chung
Hao Wang
Metabolic syndrome (MetS) causes vascular structural abnormalities, nerve damage, hormonal level changes and other lesions, which promote the occurrence and development of erectile dysfunction (ED). Penile vascular endothelial dysfunction i...
Neutrophil Recruitment via Hepatocyte IL-1α Drives NETs-Mediated AIM2 Hepatocyte Apoptosis in Alcohol-associated steatohepatitis [0.03%]
酒精相关性steatohepatitis中肝细胞分泌的IL-1α驱动中性粒细胞招募并促进NETs介导的AIM2依赖性的肝细胞凋亡
Yuan Zhang,Xueteng Meng,Yan Ding et al.
Yuan Zhang et al.
Alcohol-associated steatohepatitis (ASH) represents a critical stage in the progression of Alcohol-associated liver disease (ALD), characterized by extensive hepatocellular steatosis, immune cell infiltration, and a poor therapeutic respons...
Unravelling the Intricate Link: Mast Cells and Estrogen-Induced Pain Sensitization in Endometriosis [0.03%]
子宫内膜异位症中雌激素诱导的疼痛敏感化与肥大细胞的复杂联系解析
Jianzhang Wang,Xinqi Mao,Libo Zhu et al.
Jianzhang Wang et al.
Endometriosis is a prevalent gynaecological disorder characterized by estrogen-dependent lesions. Pain-particularly dysmenorrhea, chronic pelvic pain, and dyspareunia-is the hallmark symptom of endometriosis. While pain mechanisms remain po...
The KLF4/Galectin-3 cascade is a key determinant of tubular cell death and acute kidney injury [0.03%]
KLF4/Galectin-3信号通路是肾小管上皮细胞坏死及急性肾损伤的关键因素
Lishan Liu,Fangxu Chen,Kang Liu et al.
Lishan Liu et al.
Clinically, acute kidney injury (AKI) stems from a diverse array of causes including ischemia, exposure to nephrotoxic agents, or sepsis. Renal tubular cells are particularly vulnerable and often sustain the most significant damage during A...
TPL2 Promotes Gastric Cancer Progression and Chemoresistance Through a Hypoxia-Induced Positive Feedback Loop with PPARδ [0.03%]
HIF-1诱导的PPARδ/TPL2正反馈回路促进胃癌的耐药和进展
Keng-Li Lan,De-Wei Lai,Cheng-Ning Yang et al.
Keng-Li Lan et al.
Tumor progression locus 2 (TPL2), a member of the MAP3K serine/threonine protein kinase family, is implicated in immune responses and pro-inflammatory protein phosphorylation. Emerging evidence suggests its role in tumorigenesis; however, i...
Cyclin D1/CDK coordination with the cellular prion protein upregulated cell proliferation signaling and preserved neurological function in acute IS rats [0.03%]
cyclin D1/CDK与细胞型朊蛋白的协调作用可上调急性缺血大鼠的细胞增殖信号并保持其神经功能
Kun-Chen Lin,Kuan-Hung Chen,John Y Chiang et al.
Kun-Chen Lin et al.
We tested how the coordination between cyclin D1/cyclin-dependent kinase (CDK) and the cellular prion protein (PrPC) activates mitogenic/cell proliferation signaling to improve neurological outcomes in acute ischemic stroke (AIS) rats. Comp...
Remodeling the Tumor Immune Environment in Breast Cancer via Bortezomib-based Combination Therapy [0.03%]
通过硼替佐米联合治疗重塑乳腺肿瘤免疫微环境
Shaojuan Huang,Qiang Chen
Shaojuan Huang
While proteasome inhibitors have revolutionized the treatment of hematologic malignancies and significantly improved patient survival, their efficacy in solid tumors remains limited. The recent work by Tang and colleagues demonstrates a nov...
TGF-βI/FERMT2/ COL6A1 Reciprocal Loop Drives Tumor-Stroma Crosstalk and Promotes Peritoneal Metastasis in Gastric Cancer [0.03%]
转化生长因子-β I/FERMT2/COL6A1互作环路驱动肿瘤基质互作并促进胃癌腹膜转移
Chao He,Zheng Zhou,Jiayue Ye et al.
Chao He et al.
Background: Peritoneal metastasis (PM) is a frequent and fatal progression in advanced gastric cancer (GC), shaped by intricate interactions between tumor cells and the tumor microenvironment. Among these, gastric cancer-associated fibrobla...
TRAF2 Promotes Liver Fibrosis via Regulation of the HIF-1α/GLUT1-Mediated Glycolysis in Hepatic Stellate Cells [0.03%]
TRAF2通过调节HIF-1α/GLUT1介导的肝星状细胞糖酵解促进肝纤维化
Yina Zhang,Siduo Xu,Jiajia Shao et al.
Yina Zhang et al.
Tumor necrosis factor receptor-associated factor 2 (TRAF2) is an intracellular aptamer protein with E3 ligase activity and has been reported to be involved in the pathogenesis of hepatitis and liver cancer. However, the specific mechanism f...