Synergistic Effects of Radiotherapy and PD‑1 Blockade in a Human‑Mimetic BRCAness Model of Triple-Negative Breast Cancer [0.03%]
三阴性乳腺癌类BRCAness人源模型中放疗与PD-1阻断的协同作用效应
Eun Ju Cho,Min Kyung Ki,Hye Jung Baek et al.
Eun Ju Cho et al.
BRCA1‑deficient triple‑negative breast cancer (TNBC) presents significant treatment challenges owing to the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) targets, exhibi...
TTC36-Mediated Tumor Suppression via YBX3/SPRED1 Axis Paradoxically Reduces Sorafenib Sensitivity in Hepatocellular Carcinoma [0.03%]
TTC36通过YBX3/SPRED1轴抑制肿瘤但会降低肝细胞癌对索拉非尼的敏感性
Wenhu Zhao,Xiangyu Ling,Kuan Li et al.
Wenhu Zhao et al.
Background: Hepatocellular carcinoma (HCC) exhibits limited therapeutic responses, partly due to undefined tumor suppressor networks. While TTC36 is downregulated in HCC and correlates with poor prognosis, its functional role, molecular mec...
Cardiomyocyte GSDME Drives Doxorubicin-Induced Cardiotoxicity by Targeting the CCL2-CCR2 Axis [0.03%]
心脏成纤维细胞中GSDME通过靶向CCL2-CCR2轴驱动多柔比星诱导的心脏毒性
Junqiang Xue,Shiyao Xie,Xuelin Cheng et al.
Junqiang Xue et al.
The use of doxorubicin (DOX), a wide-spectrum antineoplastic drug, is largely limited in clinical practice because of the less than satisfactory strategies available for the prevention and treatment of doxorubicin-induced cardiotoxicity (DI...
DPP7 promotes fatty acid β-oxidation in tumor-associated macrophages and determines immunosuppressive microenvironment in colorectal cancer [0.03%]
DPP7通过促进肿瘤相关巨噬细胞中的脂肪酸β氧化决定结直肠癌免疫抑制微环境
Jiang Chang,Yuxu Niu,Shizhao Zhou et al.
Jiang Chang et al.
Background: Tumor-associated macrophages (TAMs) are pivotal mediators of the immunosuppressive tumor immune microenvironment (TIME) in colorectal cancer (CRC). However, genes of TAMs that potentiate immunotherapy remain to be explored. Meth...
Dysregulation of SRSF3/ circSAMD4/CIRBP Axis Promotes Iodinated Contrast-induced Acute Kidney Injury [0.03%]
SRSF3/circSAMD4/CIRBP轴失调促进碘化对比剂所致急性肾损伤
Xi Wu,Ting Wu,Xiufen Wang et al.
Xi Wu et al.
Iodinated contrast agents are a common cause of contrast-induced acute kidney injury (CI-AKI), yet the underlying mechanisms remain unclear. We found that circSAMD4 is markedly upregulated in renal tubular epithelial cells (RTECs) from iohe...
Tumor-Derived Lactate Drives Malignant Progression of Refractory Papillary Thyroid Carcinoma via the H3K18la-STAT1-LDHA Axis [0.03%]
肿瘤衍生的乳酸通过H3K18la-STAT1-LDHA轴驱动难治性乳头状甲状腺癌恶性进展
Zheng Zhou,Chao He,Xumeng Wang et al.
Zheng Zhou et al.
Papillary thyroid carcinoma (PTC) remains among the most prevalent endocrine malignancies globally, with its incidence steadily rising. Although clinical outcomes are generally favorable, a clinically significant subset of patients exhibits...
Lung Cancer Cell-intrinsic Asparagine Synthetase Potentiates Anti-Tumor Immunity via Modulating Immunogenicity and Facilitating Immune Remodeling in Metastatic Tumor-draining Lymph Nodes [0.03%]
肺癌细胞源性天冬酰胺合成酶通过调节转移瘤引流淋巴结免疫原性和重塑抗肿瘤免疫微环境促进抗癌免疫反应
Ziyu Zhang,Nannan Du,Gege He et al.
Ziyu Zhang et al.
Background: In non-small cell lung cancer (NSCLC), lymph node (LN) metastasis is a crucial prognostic factor. Asparagine synthetase (ASNS) plays a crucial role in cellular aspartate metabolism and promotes LN metastasis. However, the mechan...
Disruption of the Clock Component BMAL1 in HDM-induced Asthma Causes GC Resistance in Airway Epithelial Cells by Regulating GR Phosphorylation through the DUSP4-p38MAPK Pathway [0.03%]
CLOCK成分BMAL1的干扰通过DUSP4-p38 MAPK通路调节GR磷酸化在HDM诱导的哮喘中引起气道上皮细胞对GC耐药性
Haohua Huang,Hua Liao,Yixin Chen et al.
Haohua Huang et al.
Circadian rhythm disruption has been increasingly implicated in asthma and glucocorticoid (GC) resistance. In this study, we discovered that disruption of the brain and muscle ARNT-like 1 (BMAL1), a significant activator of the circadian cl...
Unveiling the dynamics and therapeutic potential of m6A methyltransferases and demethylases in liver diseases [0.03%]
揭秘m6A甲基转移酶和去甲基酶在肝病中的动态变化及治疗潜力
Ya-Ning Chen,Sai Zhu,Li-Jiao Sun et al.
Ya-Ning Chen et al.
N6-methyladenosine (m6A), a well-known adenosine modification with newly recognized epigenetic functions, reportedly participates in the development of diverse liver diseases. Methyltransferases and demethylases, commonly referred to as "wr...
Repetitive Trans-spinal Magnetic Stimulation Suppresses Microglia to Engulf Synapse and Promotes Nerve Repairment via cGAS-STING Signaling Pathway after Spinal Cord Injury [0.03%]
重复经脊髓磁刺激通过cGAS-STING信号通路抑制小胶质细胞吞噬突触促进脊髓损伤后神经修复
Mudan Huang,Jiawei Di,Na Li et al.
Mudan Huang et al.
Background: Spinal cord injury (SCI) is a neurological disorder characterized by progressive neuronal death. Notably, microglia-mediated synapse phagocytosis contributes to the disruption of the surviving neuronal network. Recovery of neuro...