Gut microbial-derived metabolites: key players in kidney disease and renal fibrosis [0.03%]
肠道微生物代谢产物：肾脏疾病和肾纤维化的关键因素
Wan-Ying Zhang,Yu-Lu Zhang,Qing-Qing Yu et al.
Wan-Ying Zhang et al.
Kidney disease is a major global public health problem that affects 15-20% of adults globally. Increasing evidence shows that kidney injury results in intestinal barrier dysfunction, microbial dysbiosis, and microbial-derived metabolite dis...
E3 ligase UHRF2 hijacks nuclear TBK1 to epigenetically repress type I interferons expression [0.03%]
E3连接酶UHRF2劫持核TBK1表观遗传学抑制I型干扰素的表达
Wenwen Huang,Renjie Song,Qicong Shen et al.
Wenwen Huang et al.
The rapid induction of type I interferons (IFN-I) by innate signaling is indispensable for host defense; however, its uncontrolled expression invariably leads to autoimmune diseases. Here, we reveal that the E3 ubiquitin ligase UHRF2 functi...
Impaired Neuregulin 1 Processing is Associated with Synaptic and Behavioral Abnormalities in a Prenatal Valproic Acid Model of Autism [0.03%]
神经发育障碍模型中Neuregulin 1加工异常与突触和行为异常有关
Yu-Jin Kim,Han-Byeol Kim,Hyo-Min Lim et al.
Yu-Jin Kim et al.
Autism spectrum disorder (ASD) is characterized by deficits in social communication and restricted/repetitive behaviors, yet the molecular mechanisms by which prenatal environmental insults lead to circuit dysfunction remain incompletely un...
YY1 Lactylation Elicits CARD9 Deficiency in Dendritic Cells Promoting Pancreatic Cancer Immune Escape [0.03%]
YY1乳酰化通过引起树突状细胞中CARD9缺乏促进胰腺癌免疫逃逸
Lingyan Ding,Cheng Tian,Yiting Feng et al.
Lingyan Ding et al.
Pancreatic cancer (PC) cells suppress dendritic cell (DC) maturation and function through multiple pathways, further impairing antitumor activity of CD8+ T cells. Our previous study revealed that caspase-recruitment domain-containing protei...
PSMC5 Orchestrates an Immunosuppressive Niche and Metastasis in Colorectal Cancer via SMURF1-Mediated K11-Linked Ubiquitination of METTL14 [0.03%]
PSMC5通过SMURF1介导的METTL14K11连接泛素化在结直肠癌中调控免疫抑制微环境及转移
Yi Zhang,Xiao Yang,Hua Zhong et al.
Yi Zhang et al.
Colorectal cancer (CRC) metastasis requires coordination between tumor-intrinsic programs and the surrounding microenvironment, yet how proteasomal regulation intersects with the epitranscriptome in this process remains unclear. Here, analy...
A context-dependent METTL1-m7G-SLC7A11 axis links metabolic stress to epithelial fate in ulcerative colitis [0.03%]
一个依赖于上下文的METTL1-m7G-SLC7A11轴将代谢压力与溃疡性结肠炎中的上皮细胞命运联系起来
Lichao Yang,Qi Sun,Zhixian Jiang et al.
Lichao Yang et al.
Ulcerative colitis (UC) is characterized by chronic intestinal inflammation accompanied by epithelial barrier dysfunction and profound metabolic stress; however, how metabolic cues are integrated to determine epithelial cell fate remains in...
SQSTM1/p62 UFMylation Enhances Autophagic Clearance of Pathogenic Mutant Huntingtin [0.03%]
SQSTM1/p62 携带泛素的修饰增强病理性突变亨廷顿蛋白的自噬清除作用
Xiaohui Wang,Xiaowei Lv,Honglv Jiang et al.
Xiaohui Wang et al.
Ubiquitin-fold modifier 1 (UFM1) covalently modifies protein substrates (UFMylation) and alters their biological functions. Genetic screening disclosed that enzymes in the UFMylation system play critical roles in regulating autophagy. Howev...
SPARC Drives Tubulointerstitial Fibrosis through Regulating the CBP-DOT1L Pathway [0.03%]
SPARC通过调节CBP-DOT1L通路驱动肾间质纤维化
Huimin Jiang,Qing Yang,Kuo Wang et al.
Huimin Jiang et al.
Renal tubulointerstitial fibrosis (TIF) is a central pathological feature driving the progression of chronic kidney disease (CKD) toward end-stage renal failure. Despite advances in understanding fibrotic mechanisms, effective anti-fibrotic...
PIP5K1A-PIP2-RhoA Signaling Orchestrates Membrane Remodeling during Early Porcine Embryo Development [0.03%]
PIP5K1A-PIP2-RhoA信号通路调控早期猪胚胎发育过程中的膜重塑事件
Cheng-Lin Zhan,Song-Hee Lee,Zheng-Wen Nie et al.
Cheng-Lin Zhan et al.
Dynamic plasma membrane remodeling is fundamental for cleavage, signal transduction, and cytoskeletal organization during mammalian embryogenesis. Although oocyte activation triggers membrane remodeling and elevates phosphatidylinositol (4,...
Fangchinoline Activates cGAS-STING to Promote Antitumor Immunity without Pathological Inflammation [0.03%]
三尖杉生物碱方氯宁通过激活cGAS-STING通路促进抗肿瘤免疫应答而不引起病理炎症反应
Yang Zhao,Xingyu Chen,Yunfei Xie et al.
Yang Zhao et al.
Effective cancer immunotherapy requires strengthening tumor-directed immunity while avoiding pathological inflammation, highlighting an urgent need for single agents that can achieve this balance. Here, we identified fangchinoline (Fan) as ...