SREBP2-activated CNPY3 Phase Separation Promotes Colorectal Cancer by Enhancing MDM2-mediated p53 Degradation [0.03%]
SREBP2激活的CNPY3相分离通过增强MDM2介导的p53降解促进结直肠癌发生发展
Xue Li,Min-Yue Yin,Yan-Fei Wei et al.
Xue Li et al.
Dysregulated cholesterol metabolism is a recognized metabolic hallmark of cancer. While the transcription factor SREBP2 is a master regulator of this pathway, how its activation converts metabolic stress into the development of carcinogenic...
Alpha-ketoglutarate Potentiates IL-1β Production and Suppressive Mechanisms of Myeloid-Derived Suppressor Cells by Altering Redox Metabolism and Inducing Autophagy [0.03%]
α-酮戊二酸通过改变氧化还原代谢和诱导自噬来增强IL-1β的产生和髓系来源的抑制细胞的抑制机制
Marijana Milanović,Luka Pavlović,Marina Bekić et al.
Marijana Milanović et al.
Alpha-ketoglutarate (αKG) has shown promise in cancer immunotherapy due to its profound impact on cancer cell metabolism and gene expression. However, its effects on myeloid-derived suppressor cells (MDSCs), critical immunosuppressive comp...
Neutrophil Extracellular Traps in Pancreatic Ductal Adenocarcinoma: A Vicious Cycle in the Tumor Microenvironment and Targeted Interventions [0.03%]
胰腺导管腺癌中的中性粒细胞胞外诱捕网：肿瘤微环境中的恶性循环及靶向干预措施
Lin Zhao,Haodong Yuan,Zixiang Chen et al.
Lin Zhao et al.
Neutrophil extracellular traps (NETs) are web-like structures released by activated neutrophils and initially identified for their role in antimicrobial defense. In recent years, growing evidence has demonstrated that NETs contribute to the...
Endothelial Klf9 fine-tunes Akt signaling to act as a transcriptional brake restraining retinal angiogenesis [0.03%]
内皮细胞Klf9通过调节Akt信号转导作为转录制动子抑制视网膜血管生成
Honglian Wu,Tianjing Yang,Yuning Xun et al.
Honglian Wu et al.
Retinal angiogenesis requires precise transcriptional regulation. Krüppel-like factor 9 (Klf9) has been implicated in various biological processes; however, its specific role in retinal vascular development and ocular neovascular disease r...
VDR-Spermidine Axis Protects Against Age-Related Granulosa Cell Dysfunction and Follicular Decline via DNMTs-Mediated p53 Methylation [0.03%]
VDR- spermidine轴通过DNMT介导的p53甲基化保护免于年龄相关颗粒细胞功能障碍和卵泡衰竭
Haiyun Chen,Qinghe Geng,Qiuyi Wang et al.
Haiyun Chen et al.
Ovarian aging, marked by a decline in follicle quantity and quality, is a complex process whose underlying mechanisms remain elusive. Here, we identify the vitamin D receptor (Vdr) as a key anti-aging transcription factor whose expression i...
The function of TLR2 and the microbiome in macrophage-dependent dissemination of nontuberculous mycobacterial gut infection [0.03%]
TLR2和微生物群在鸟分枝杆菌肠道感染巨噬细胞依赖性扩散中的作用
Li Liu,Wanbin Hu,Herman P Spaink
Li Liu
Background: Nontuberculous mycobacteria (NTM) infections are increasing in incidence and mortality worldwide, yet the in vivo determinants of early intestinal colonization and subsequent dissemination remain poorly define...
Plasticity-Driven Regeneration of Circumvallate Papilla After Lgr5+ Stem Cells Loss [0.03%]
Lgr5+干细胞缺失后的犁状乳头塑性驱动再生
Senthil Kumar Baskaran,Anish Ashok Adpaikar,Suyeon Lee et al.
Senthil Kumar Baskaran et al.
Taste receptor cells located within the papillae of the oral cavity have a defined lifespan of 8-12 days. They are continuously replenished by a pool of stem/progenitor cells residing outside the taste buds. Previous studies have identified...
Impaired redox adaptation through SLC38A5-dependent glutamine metabolism contributes to melatonin-mediated anoikis sensitivity and metastasis suppression in bone cancer [0.03%]
SLC38A5介导的谷氨酰胺代谢导致抗氧化应激能力下降促进褪黑素诱导的骨癌细胞anoikis及抗转移作用
Bao Tran Nguyen,Wei-Cheng Chen,Yi-Chin Fong et al.
Bao Tran Nguyen et al.
Malignant bone cancer, primarily osteosarcoma and chondrosarcoma, are highly aggressive neoplasms originating from bone tissue and characterized by a strong propensity for lung metastasis. Tumor cells evade anoikis through reactive oxygen s...
Phase separation of p85β modulates hepatocellular carcinoma progression through POLR1A [0.03%]
p85β相分离通过POLR1A调控肝癌进展
Yifan Zhang,Dong Zhang,Yi Duan et al.
Yifan Zhang et al.
PI3K complex consists of catalytic subunit p110s and regulatory subunit p85s. Emerging evidence indicates that p110-free p85 subunits play pivotal roles in diverse biological processes, including cancer progression. In this study, we demons...
Biomembrane-coated Nanoparticles Targeting circHIF1α Suppress Ovarian Cancer Metastasis and Cisplatin Resistance by Mediating System Xc⁻ Inactivation via SLC7A11/SLC3A2 to Induce Ferroptosis in Cancer Stem Cells [0.03%]
生物膜涂层纳米颗粒通过调控circHIF1α介导的系统Xc⁻失活诱导卵巢癌干细胞铁死亡以抑制卵巢癌转移和顺铂耐药性
Yinyi Chang,Jingjing Wang,Liying Ma et al.
Yinyi Chang et al.
The hypoxic tumor microenvironment (TME) drives malignant progression by increasing the activity of cancer stem cells (CSCs), whose iron-dependent metabolism not only maintains their stemness but also promotes drug resistance and ferroptosi...