Cardiac fibroblast-derived IGFBP6 orchestrates cardiac remodeling by coupling the EGR1-MFAP4 axis [0.03%]
心肌纤维母细胞衍生的IGFBP6通过连接EGR1-MFAP4轴调控心脏重塑
Shaopeng Cheng,Yilin Wang,Kunsheng Li et al.
Shaopeng Cheng et al.
Rationale: The transition of fibroblasts into activated myofibroblasts is a pivotal driver of collagen deposition and adverse cardiac remodeling. Insulin-like growth factor-binding protein 6 (IGFBP6), a critical modulator of cellular growth...
The Remodeling of Mitochondrial-Endoplasmic Reticulum Contacts by Omega-3 Fatty Acids Mitigates Dietary Advanced Glycation End Product-Driven Sertoli Cell Senescence and Oligoasthenozoospermia [0.03%]
ω-3脂肪酸重塑线粒体-内质网接触点可缓解饮食晚期糖基化终产物驱动的精细细胞衰老和弱精症
Zhaowanyue He,Feiyan Ge,Chuwei Li et al.
Zhaowanyue He et al.
Dietary components or patterns have been shown to affect male fertility. The increasing intake of processed foods rich in advanced glycation end products (AGEs) may threaten spermatogenesis. However, the key cell type affected by AGEs in sp...
Role of Ubiquitin-regulated EMT in Cancer Metastasis and Chemoresistance [0.03%]
泛素调节的上皮间质转化在癌症转移和化疗耐药中的作用
Shuai Xiao,Lingli Tian,Xiaoli Gan et al.
Shuai Xiao et al.
Epithelial-mesenchymal transition (EMT) is a fundamental biological process that promotes cancer metastasis and chemoresistance. However, the therapeutic efficacy of EMT inhibitors remains limited. Ubiquitination, a critical post-translatio...
Glycolysis drives STING signaling to promote M1-macrophage polarization and aggravate liver fibrosis [0.03%]
糖酵解通过促进STING信号转导来促进M1型巨噬细胞极化并加重肝纤维化
Ping Chen,Zijing Zhu,Wenjie Chen et al.
Ping Chen et al.
Glycolysis activation plays a critical role in sustaining the proinflammatory phenotype of macrophages, which is key to initiating and advancing liver fibrosis. However, the underlying mechanisms that trigger glycolytic activation and their...
STK32C as a Therapeutic Target in Colorectal Cancer via HSP90-PI3K/AKT/mTOR Signaling [0.03%]
STK32C通过HSP90-PI3K/AKT/mTOR信号传导在结直肠癌治疗中的靶点作用研究
Chi-Hoon Ahn,Ji Eon Park,Deok Yong Sim et al.
Chi-Hoon Ahn et al.
Emerging evidence implicates serine/threonine kinase 32C (STK32C) overexpressed in bladder cancer and brain tissues acts as a molecular target for doxorubicin resistance, yet its role in colorectal cancer (CRC) remains unclear. Thus. this s...
METTL3-mediated m6A methylation on lncRNA H19 inhibits intrahepatic cholangiocarcinoma progression through PPARγ downregulation [0.03%]
METTL3介导的lncRNA H19上m6A甲基化通过下调PPARγ抑制肝内胆管癌进展
Rong Xiao,Xinya Lu,Fang Huang et al.
Rong Xiao et al.
Intrahepatic cholangiocarcinoma (ICCA), the second most prevalent primary liver malignancy, remains poorly understood at the molecular level. Research into the function of N6-methyladenosine (m6A) modification in the formation of ICCA and i...
Outer Membrane Vesicles Derived from Oral Bacteria Act as a Dagger in Host Immunity: Insight Tips from Local Diseases to Systemic Effects [0.03%]
口腔细菌衍生的外膜囊泡作为刺宿主免疫的武器：从局部疾病到全身影响的新见解
Xinyue Zhang,Jianing Wu,Zhe Zhang et al.
Xinyue Zhang et al.
Outer membrane vesicles (OMVs) are secreted by gram-negative bacteria and are genetically and environmentally regulated. The contents of OMVs are derived from the outer membrane and periplasm of bacteria, that can act as virulence factors t...
Gli1 regulates fibro/adipogenic progenitor function through modulation of Ido1 in muscle regeneration [0.03%]
Gli1通过调节Ido1调控肌纤维/脂肪前体细胞功能以促进肌肉再生
Lili Han,Fengmin Zhang,Jujin Zhang et al.
Lili Han et al.
Gli1 is a critical marker of diverse stem cell populations across multiple tissues and is essential for tissue regeneration. However, its functional relevance in skeletal muscle has remained largely unexplored. Here, we demonstrate that Gli...
Jude Uzoechina,Zhijun Zhang
Jude Uzoechina
Circular RNAs (circRNAs) are structurally stable and covalently-linked ring RNA molecules. Due to backsplicing, they are directly joined by phosphodiester linkage, which confers much greater stability relative to their linear mRNA counterpa...
An efficient neural network of cooperating serotonergic and noradrenergic neurons in modulating sudden unexpected death in epilepsy [0.03%]
一种高效的神经网络通过协同作用的血清素能和去甲肾上腺素能神经元调节癫痫猝死
Qing Xu,XiaoXia Xu,LeYuan Gu et al.
Qing Xu et al.
Sudden unexpected death in epilepsy (SUDEP) is a critical concern, with seizure-induced respiratory arrest (S-IRA) being a major contributing factor. The serotonergic (5-HT) and noradrenergic (NE) neurons have emerged as key modulators of S...