Esophageal Small Cell Carcinoma: From Bench Discoveries to Bedside Therapeutics [0.03%]
从实验研究到临床治疗：食管小细胞癌的研究进展
Zhe Wang,Jiayi Zhang,Cheng Ji et al.
Zhe Wang et al.
Small cell carcinoma of the esophagus (SCCE) is both rare and aggressive. Lacking its own guidelines, it has historically been managed with treatment models borrowed from small cell lung cancer (SCLC). However, advances in multi-omics and i...
WDR82 suppresses breast cancer progression by inhibiting ERK-driven chemokine expression and neutrophil infiltration [0.03%]
WDR82通过抑制ERK驱动的细胞因子表达和中性粒细胞浸润来抑制乳腺癌进展
Qinyi Yu,Jiang Yang,Fengjiao Lu et al.
Qinyi Yu et al.
Elucidating tumor-intrinsic mechanisms orchestrating immunosuppressive tumor microenvironment (TME) and cancer immunoevasion is essential for overcoming cancer immunotherapy resistance and developing novel therapeutic strategies. WDR82, a m...
Targeting QRICH1 suppresses epithelial-mesenchymal transition and tumor growth in liver cancer through the Connexin43/USP1 mediated Snail1 stabilization [0.03%]
靶向QRICH1通过缝隙连接蛋白43/USP1介导的Snail1稳定抑制肝癌上皮间质转化和肿瘤生长
Su-Yeon Park,Bum-Sang Shim,Bonglee Kim et al.
Su-Yeon Park et al.
Although glutamine-rich protein 1 (QRICH1) has been implicated in endoplasmic reticulum stress-associated epithelial-mesenchymal transition (EMT), its mechanistic role in liver cancer progression remains unclear. QRICH1 expression was analy...
Unveiling Interleukin-40: A Novel Regulator of Macrophage and B Cell Function in Allergic Asthma [0.03%]
IL-40：过敏性哮喘中调节巨噬细胞和B细胞功能的新因子
Aixuan Li,Katie Ching-Yau Wong,Danqi Huang et al.
Aixuan Li et al.
Allergic asthma is characterized by chronic airway inflammation and heightened type 2 immune responses. Although inhaled corticosteroids are the mainstay of therapy, a subset of patients exhibits suboptimal responses, underscoring the need ...
RNA variation as the driver of genomic efficiency and phenotypic complexity [0.03%]
RNA变异驱动的基因组效率和表型复杂度
Zhihua Jiang,Michee van Rooyen,Jennifer J Michal et al.
Zhihua Jiang et al.
Despite decades of genome sequencing and annotation, a fundamental paradox remains unresolved: how organisms with finite and relatively stable gene numbers generate extraordinary phenotypic diversity. In this review, we propose that regulat...
CD109 Drives Stemness and Chemoresistance in Colorectal Cancer via LRRC8A/AKAP12/PKCα-Mediated STAT3 Activation and WNT Signaling [0.03%]
通过LRRC8A/AKAP12/PKCα介导的STAT3活化和Wnt信号传导驱动结直肠癌干细胞特性和化疗抗性的CD109
Rubén A Bartolomé,Tania Calvo-López,Pablo Otero-Núñez et al.
Rubén A Bartolomé et al.
Colorectal cancer (CRC) is the third most prevalent type of cancer worldwide, with a poor survival rate at the metastatic stage. Here, we identify CD109-a negative regulator of TGFβ signaling-as a key driver of stemness and drug resistance...
H3K18la-PSMG1 Axis in Bladder Cancer Progression: Curcumin as a Therapeutic Candidate [0.03%]
花青作为治疗候选药物的膀胱癌进展中的H3K18la-PSMG1轴
Zhe Yu,Jinge Zhang,Zihuan Wang et al.
Zhe Yu et al.
Although multiple therapeutic modalities, including surgery, chemotherapy, radiotherapy, immunotherapy, and targeted therapy, have improved the management of bladder cancer, the clinical outcome of muscle-invasive bladder cancer (MIBC) rema...
USP33 Promotes Lung Adenocarcinoma Brain Metastasis by Inhibiting the K48-Linked Ubiquitination and Degradation of S100A9 and Facilitating Vimentin Secretion [0.03%]
USP33通过抑制K48连接的泛素化和S100A9降解并促进波形蛋白分泌来促进肺腺癌脑转移
Zihao Wang,Mengqi Chang,Yuekun Wang et al.
Zihao Wang et al.
Brain metastasis has a deterministic influence on the evolutionary trajectory of lung adenocarcinoma (LUAD). Given the profound clinical importance of LUAD brain metastases and the formidable obstacles that hinder their precise prediction, ...
Fibrillin-1 Orchestrates a Pro-senescent Niche Driving Peritubular Endothelial Senescence via ZEB1/endothelin-1/β-catenin Signaling [0.03%]
纤维蛋白酶原-1通过ZEB1/内皮素-1/β-连环蛋白信号引导促衰老微环境，从而导致管周内皮细胞衰老
Junxin Huang,Xiaoyao Zhang,Zifu Yao et al.
Junxin Huang et al.
Microvascular rarefaction is a predominant pathological hallmark of chronic kidney disease (CKD), functioning simultaneously as a catalyst and consequence of progressive renal compromise. Although endothelial senescence constitutes a cardin...
Role of WDR66 in Stemness, Therapy Resistance and Tumor microenvironment modulation in Head and Neck Cancer [0.03%]
WDR66在头颈鳞癌肿瘤干细胞特性、耐药及微环境调控中的作用研究
Laura Sanchez-Diaz,Asuncion Espinosa-Sánchez,Amancio Carnero
Laura Sanchez-Diaz
Head and neck cancer comprises a variety of malignant tumors affecting regions such as the oral cavity, pharynx, larynx, paranasal sinuses, nasal cavity and salivary glands. These tumors are highly heterogeneous, making it difficult to iden...