GDF10 attenuates MASH progression by restoring quiescent hepatic stellate cells via competitive inhibition of TGF-β/SMAD2 signaling [0.03%]
GDF10通过竞争性抑制TGF-β/SMAD2信号转导恢复静息态肝星状细胞从而遏制血管化纤维化进展
Yajie Peng,Hongyan Lei,Jiahui Zhao et al.
Yajie Peng et al.
Liver fibrosis has emerged as the primary determinant of outcomes in metabolic dysfunction-associated steatohepatitis (MASH). Quiescent hepatic stellate cells (HSCs) differentiate into activated HSCs or myofibroblasts, which drives liver fi...
Macrophage Immunometabolism in Pulmonary Homeostasis and Chronic Lung Diseases [0.03%]
肺泡巨噬细胞的免疫代谢在肺系稳态和慢阻肺中的作用机制研究
Cong Xie,Maimaititusun Yalikun,Zhenhui Ruan et al.
Cong Xie et al.
Macrophages play a central role in maintaining pulmonary immune homeostasis and responding to injury. In the lung, alveolar macrophages modulate their metabolic profiles to support essential functions such as microbial clearance, inflammati...
Quercetin Protects Against Transmissible Gastroenteritis Virus-Induced Intestinal Inflammation by Modulating Mitophagy-Driven Mitochondrial Dysfunction [0.03%]
檞皮素通过调节线粒体自噬驱动的线粒体功能障碍来保护小鼠传染性胃肠炎病毒诱导的肠道炎症
Kang Wang,Zhentao He,Yan Li et al.
Kang Wang et al.
Transmissible gastroenteritis virus (TGEV), an enteropathogenic α-coronavirus, causes severe disruption of the intestinal epithelium and diarrhea in neonatal piglets. Despite growing evidence linking mitochondrial dysfunction to coronaviru...
Human Pluripotent Stem Cell-Derived Alveolar Organoids for Gene-editing and Lung Adenocarcinomas Modeling [0.03%]
人多能干细胞来源的肺泡类器官用于基因编辑和肺腺癌建模
Lian Li,Yuchen Liu,Lifan Liu et al.
Lian Li et al.
Human pluripotent stem cell (hPSC)-derived alveolar organoids have emerged as valuable tools for studying lung development, modeling pulmonary diseases, and drug discovery, though their application has been hindered by laborious differentia...
Lactobacillus paracasei ZJUZ2-3 inhibits gastrointestinal tumors via the IAA-induced AHR/MTDH/NF-κB axis [0.03%]
植物乳杆菌ZJUZ2-3通过IAA诱导的AHR/MTDH/NF-κB轴抑制肠道肿瘤
Rui Yang,Yan Yang,Lin Wu et al.
Rui Yang et al.
Lactobacillus paracasei abundance is markedly reduced in gastric cancer (GC) tissues, suggesting its potential protective role. From healthy gastric tissue of a GC patient, we isolated a novel strain, L. paracasei ZJUZ2-3, which exerted pot...
Maria Chiara Iachini,Alberto Coglot,Dorian Tace et al.
Maria Chiara Iachini et al.
The development of physiologically relevant in vitro 3D models is crucial for studying lung biology and disease mechanisms. While airway organoids have significantly improved our ability to mimic lung tissue, they lack key nonepithelial com...
Spatial Cell Atlas of Lateral Septum Reveals Changes Underlying Anxiety and Fear Learning Deficits in Mice with Abnormal Immunity [0.03%]
侧隔室空间细胞图谱揭示了小鼠异常免疫相关焦虑和恐惧学习缺陷的机制
Yian Wang,Wenxia Gao,Xueyan Yang et al.
Yian Wang et al.
The lateral septum (LS) regulates affective-cognitive processes and is dysregulated in human psychiatric disorders. Its functional complexity stems from heterogeneous connectivities and neuronal subtype compositions across anatomical subreg...
Macrophage Extracellular Traps Modulate the Compensatory Anti-inflammatory Response Syndrome through IL-33/ST2 Signaling in Severe Acute Pancreatitis [0.03%]
巨噬细胞外陷阱通过IL-33/ST2信号调节急性重症胰腺炎的代偿性抗炎反应综合征
Quan Zhou,Zhao Shi,Xuan Wang et al.
Quan Zhou et al.
Severe acute pancreatitis (SAP) is characterized by biphasic systemic inflammation, progressing from initial pro-inflammatory systemic inflammatory response syndrome (SIRS) to subsequent immunosuppressive compensatory anti-inflammatory resp...
Disrupting DDB2-DNA Interaction by Lapatinib Enhances Chemotherapy Sensitivity [0.03%]
拉帕替尼干扰DDB2-DNA互作可增强化疗敏感性
Shih-Chao Hsu,Yu-Hao He,Yun-Ju Chen et al.
Shih-Chao Hsu et al.
Chemoresistance remains an obstacle to effective cancer therapy across multiple tumor types. Damaged DNA-binding protein 2 (DDB2), a key component of the nucleotide excision repair (NER) pathway, contributes to chemoresistance by enhancing ...
The PI3K/Akt/mTOR Pathway: Immuno-Metabolic Orchestration in IR/MASH-Associated Hepatocellular Carcinoma [0.03%]
PI3K/AKT/mTOR信号通路在IR/MASH相关肝细胞癌免疫代谢中的作用协调
Jian Zhao,Yuehua Zhang,Zhigong Wei et al.
Jian Zhao et al.
Insulin resistance (IR) and Metabolic Dysfunction-Associated Steatohepatitis (MASH) are key drivers of hepatocellular carcinoma (HCC), yet the mechanisms underlying their induction of an immunosuppressive tumor microenvironment (TME) requir...