USP18 Impacts Cisplatin Resistance in Ovarian Cancer Cells by Modulating DNA Repair [0.03%]
USP18通过调节DNA修复影响卵巢癌细胞的顺铂耐药性
Cristina Corno,Matteo Costantino,Pietro Pettinari et al.
Cristina Corno et al.
Deubiquitinases (DUBs) are proteases with emerging roles in cancer, yet their contribution to drug resistance in ovarian cancer remains underexplored. Ovarian cancer patients often fail to benefit from platinum-based therapy, highlighting t...
Copper-Iron Cell Death Axis: Mechanistic Crosstalk, Disease Implications and an Integrated Metallo-Redox-Metabolic Framework [0.03%]
铜铁细胞死亡轴：机制相互作用、疾病影响和金属红氧代谢综合框架
HaoQi Huang,YuLu Chen,Yi Lu et al.
HaoQi Huang et al.
Cuproptosis and ferroptosis are two major forms of metal-dependent cell death, characterized by mitochondrial proteotoxicity and lipid peroxidation, respectively, and are broadly implicated in diverse disease contexts. Here, by integrating ...
Slc1a2-mediated Glutamate Transport Promotes Dendritic Cell Immunity through Sema3A-regulated Cytoskeletal Remodeling and Migration [0.03%]
Slc1a2介导的谷氨酸转运通过Sema3A调节的细胞骨架重塑和迁移促进树突状细胞免疫反应
Shanlin Chen,Bei Chen,Gongwei Li et al.
Shanlin Chen et al.
Dendritic cells (DCs) can activate T cells to trigger sustained antitumor immune responses, a process in which the continuous migration of antigen-loaded DCs from the tumor microenvironment to tumor-draining lymph nodes is critical. DCs hav...
Macrophage-Orchestrated Metabolic Sensing Drives IBD Pathogenesis: A Framework for Targeted Therapy [0.03%]
巨噬细胞代谢感知驱动炎症性肠病发病机制：靶向治疗的框架
Guangqi Guan,Xuelin Sun,Yaoxing Chen et al.
Guangqi Guan et al.
Inflammatory bowel disease (IBD) arises from dysregulated interactions among the gut microbiota, immune system, and intestinal epithelium. Intestinal macrophages are central to these processes, yet are often viewed primarily as downstream i...
RMAD1, a Novel Cell-Penetrating Peptide Derived from ADARB2: Preclinical Insights into Antigen Uptake and T Cell Activation [0.03%]
一种新型细胞穿透肽RMAD1的发现及其来源于ADARB2蛋白：抗原摄取及T细胞活化的体内研究
Chaemin Lim,Chanho Park,Ee Chan Song et al.
Chaemin Lim et al.
The development of effective cancer vaccines remains a major challenge in oncology, largely due to limited antigen delivery and suboptimal T cell priming. Here, we report RMAD1, a novel human-derived cell-penetrating peptide (CPP) originati...
Reimagining AHR in Cancer: From Environmental Sensor to Novel Immunomodulatory Therapeutic Target [0.03%]
癌症中AHR的再思考：从环境传感器到新的免疫调节治疗靶点
Yuanhao Peng,Yaxin Zhao,Yangying Zhou et al.
Yuanhao Peng et al.
The aryl hydrocarbon receptor (AHR) is an environmental sensor in mammals and a ligand-dependent, highly conserved transcription factor. It belongs to the basic helix-loop-helix family of transcription factors and is the only known ligand-a...
Targeting the exosomal CaMK2A-ZDHHC3-GPX4 pathway reprograms tumor-associated macrophages and enhances anti-PD-1/PD-L1 immunotherapy in gastric cancer [0.03%]
靶向胃癌细胞源外泌体CaMK2A-ZDHHC3-GPX4通路重编程肿瘤相关巨噬细胞并增强抗PD-1/PD-L1免疫治疗
Zetian Chen,Hongxin Huang,Yikai Shen et al.
Zetian Chen et al.
Background: Gastric cancer (GC) remains a major global health challenge, characterized by poor outcomes driven by an immunosuppressive tumor microenvironment (TME). Tumor-associated macrophages (TAMs), particularly the M2...
PFKFB3 Mediated Glycolytic Reprogramming Drives Vascular Endothelial Injury Under Chronic Intermittent Hypoxia [0.03%]
慢性间歇低氧下PFKFB3介导的糖酵解重构导致血管内皮损伤
Shi Qi Li,Yi Wang,Liu Zhang et al.
Shi Qi Li et al.
Metabolic-inflammatory crosstalk is a hallmark of cardiovascular pathogenesis. Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is an independent risk factor for cardiovascular diseases. While endothelial ...
The TRPM7 inhibitor carvacrol suppresses angiogenesis and vasculogenic mimicry in triple-negative breast cancer [0.03%]
百里香酚通过抑制TRPM7阻断三阴性乳腺癌的血管生成和类血管生成作用
Tianci Tang,Na Zhao,Moqin Qiu et al.
Tianci Tang et al.
Vasculogenic mimicry (VM) contributes significantly to tumor aggressiveness and resistance to anti-angiogenic therapies. Simultaneous inhibition of both angiogenesis and VM represents a promising strategy to improve therapeutic outcomes in ...
Comprehensive Metabolomic Profiling of Skin Lesions from Psoriasis Patients Reveals Disease Signatures [0.03%]
银屑病患者皮肤病变的全面代谢组学特征分析发现了疾病标志物
Peiyao Zhu,Yuanyuan Wang,Jie Sun et al.
Peiyao Zhu et al.
Psoriasis is a chronic skin disease caused by dysregulated immune system. Although inflammation plays a vital role, the precise chemical changes within the skin remain unclear and metabolomic profiling of skin lesions has been limited by sm...