HDAC4/MybL1/YAP novel signaling axis is required for pancreatic cancer metastasis to the liver [0.03%]
HDAC4/MybL1/YAP新信号轴是胰腺癌肝转移所必需的
Mouad Edderkaoui,Omer H M Elmadbouh,Adrian Lim et al.
Mouad Edderkaoui et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of human malignancy, and there is an urgency to develop more effective therapy. We previously showed that Metavert, a dual inhibitor of glycogen synthase kinase 3-beta (G...
Cellular Senescence in Endometrium: A Pivotal Regulator in Physiological Remodeling and Pathological Disorders [0.03%]
子宫内膜细胞衰老：生理重塑和病理障碍的关键调节因素
Zi-Yang Yan,Wen-Jie Zhou,Jiang-Feng Ye et al.
Zi-Yang Yan et al.
As a highly dynamic tissue, the endometrium undergoes complex remodeling during the menstrual cycle and pregnancy. Recent studies have revealed that cellular senescence plays a pivotal role in both physiological renewal (e.g., menstrual she...
Remodeling Cell Adhesion Releases Cardiac Potential of Human Pluripotent Stem Cells with Continuous Proliferation and Accelerated Maturation [0.03%]
重塑细胞粘附释放多能干细胞心脏潜能并实现持续增殖和加速成熟
Weiwei Liu,Chuyu Liu,Qian Wang et al.
Weiwei Liu et al.
Human pluripotent stem cells (hPSCs) can generate specific cell types for therapeutic applications. Since cell therapy often requires billions of cells for transplantation, it is essential to maximize differentiation efficiency to optimize ...
Extracellular matrix dysregulation in aging, calcification, and cancer diseases: insights into cellular senescence, inflammation, and novel therapeutic strategies [0.03%]
细胞衰老、炎症和新型治疗策略在老化、钙化及癌症疾病中基底外矩阵失调中的启示
Diego Liviu Boaru,Diego De Leon-Oliva,Patricia De Castro-Martinez et al.
Diego Liviu Boaru et al.
This review underscores the dynamic role of the extracellular matrix (ECM) in regulating cellular behavior and maintaining tissue homeostasis, highlighting its pivotal involvement in aging, calcification, and cancer diseases. In healthy tis...
Activation of GSDME by all- trans-retinal increases sensitivity to photoreceptor ferroptosis [0.03%]
全反式视黄醛激活GSDME可增加感光细胞铁死亡敏感性
Bo Yang,Kunhuan Yang,Yuling Chen et al.
Bo Yang et al.
Impaired clearance of all-trans-retinal (atRAL) due to visual cycle dysfunction contributes to photoreceptor atrophy, a key pathological hallmark of Stargardt disease type 1 (STGD1) and dry age-related macular degeneration (AMD). Prior stud...
ETV4 interacts with LOXL2 to induce epigenetic activation of NID1 during colorectal cancer progression [0.03%]
ETV4通过与LOXL2相互作用在结直肠癌进展过程中诱导NID1的表观遗传激活
Tinghui Jiang,Xin Liu,Hao Liu et al.
Tinghui Jiang et al.
Colorectal cancer (CRC) is one of the most common malignant cancers worldwide and its poor prognosis is mainly caused by metastasis. Although extensive studies, the potential molecular mechanisms of CRC metastasis are not fully understood. ...
Single-cell and spatial transcriptomic analysis reveal cellular heterogeneity and cancer cell-intrinsic major histocompatibility complex II expression in urothelial carcinoma [0.03%]
单细胞和空间转录组分析揭示了尿路上皮癌的细胞异质性以及癌细胞内在的主要组织相容性复合物II表达
Shengwei Xiong,Jian Fan,Cong Huang et al.
Shengwei Xiong et al.
Muscle-invasive (MI) urothelial carcinoma (UC) is a clinically challenging malignancy with a poor prognosis. Understanding the cellular dynamics that drive UC progression is critical for the development of optimized therapeutic strategies. ...
Metabolic Reprogramming in Urological Tumors: New Perspectives from Tumor Metabolic Phenotypes to Therapeutic Targets [0.03%]
肿瘤代谢表型至治疗靶点的泌尿系统肿瘤代谢重组的新视野
Zhuohang Li,Lin Yang,Weijia Li et al.
Zhuohang Li et al.
Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to sustain growth, evade immune surveillance, and resist therapy. Urological tumors, including prostate, bladder, and renal cancers, exhibit distinct metabolic phenotypes...
Dongyang Tang,Xiaoran Wu,Josh Haipeng Lei et al.
Dongyang Tang et al.
The proteasome plays a pivotal role in proteostasis and is deeply involved in various cellular processes. Currently, three proteasome inhibitors have been used for clinical therapies of liquid cancers with favorable efficacy, however they f...
SYT4 Interacts with PSMC6 to Facilitate Malignant Progression in Gastric Carcinoma via Activating Wnt/β-catenin Signaling [0.03%]
SYT4通过激活Wnt/β-连环蛋白信号促进胃癌恶性进展并与PSMC6相互作用
Wen Huang,Rongkui Luo,Huimei Wang et al.
Wen Huang et al.
Background: Gastric cancer (GC), a prevalent and life-threatening malignancy, poses significant challenges in diagnosis and prognosis due to its complex molecular pathogenesis. Identifying novel biomarkers and therapeutic targets is crucial...