Deciphering the Neuroautophagic Interactome: Molecular Circuits Linking Selective Autophagy to Neuropathological Cascades in Neurological Disorders [0.03%]
解析神经自噬作用组分：连接选择性自噬与神经系统疾病病理级联反应的分子回路
Pengfei Luo,Zachary D Travis,Cameron Lenahan et al.
Pengfei Luo et al.
Selective autophagy, a lysosome-dependent degradation pathway targeting specific substrates (e.g., mitochondria, protein aggregates), plays a pivotal role in maintaining neuronal homeostasis. Its dysregulation is intricately linked to neuro...
Targeting THOC2-Mediated mRNA Export Induces PARP Inhibitor Vulnerability in DNA Repair-Competent Hepatocellular Carcinoma [0.03%]
靶向THOC2介导的mRNA输出可诱导DNA修复型肝细胞癌对PARP抑制剂的敏感性
Xinli Li,Songpeng Yang,Mengxin Zhang et al.
Xinli Li et al.
Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options. While Poly (ADP-ribose) polymerase inhibitors (PARPi) exploit synthetic lethality in tumors with DNA repair defects, their clinical utility in HCC ...
Targeting IL-1α Sensitizes HNSCC to PDT by Reversing Hypoxia and NF-κB-Driven Oxidative Stress Resistance [0.03%]
靶向IL-1α通过逆转缺氧和NF-κB驱动的氧化应激抵抗使HNSCC对PDT敏感化
Zhiyin Li,Yikang Ji,Xinran Zhao et al.
Zhiyin Li et al.
Photodynamic therapy (PDT) provides non-invasive precision for superficial lesions but achieves suboptimal responses in hypoxic tumors such as head and neck squamous cell carcinoma (HNSCC). Spatially heterogeneous resistance mechanisms pose...
Nicotinamide riboside reduces glial inflammation and boosts mitochondrial function [0.03%]
尼克酸核糖降低胶质细胞炎症并增强线粒体功能
Tsering Yangzom,Anbin Chen,Bjørn Christian Lundberg et al.
Tsering Yangzom et al.
Astrocyte dysfunction plays a pivotal role in the pathogenesis of POLG-related mitochondrial diseases, yet the underlying mechanisms remain poorly understood. Here, we employed human iPSC-derived astrocytes, cortical organoids and astrocyte...
Spatial and single-cell transcriptomics reveal a HIF-1α/NF-κB-driven hypoxia-induced senescence axis in BPH epithelium [0.03%]
空间和单细胞转录组学揭示了HIF-1α/NF-κB驱动的低氧诱导的前列腺增生上皮衰老轴
Zheng Li,Shuai Hu,Zhifu Liu et al.
Zheng Li et al.
Benign prostatic hyperplasia (BPH) is an age-related prostate disorder with incompletely defined mechanisms. We integrated laser capture microdissection RNA sequencing, public single-cell RNA sequencing, public spatial transcriptomics, huma...
Sleep Deprivation Promotes Colorectal Cancer in ApcMin/+ Mice Associated with Modulation of Gut Microbiota and Related Metabolites [0.03%]
睡眠剥夺通过调节肠道菌群及其代谢物促进APC Min/+小鼠结直肠癌发生
Jia Chen,Rishun Su,Yong Kuang et al.
Jia Chen et al.
Sleep deprivation (SD) has emerged as an important environmental factor associated with colorectal cancer (CRC); however, the underlying mechanisms, particularly those involving the gut microbiota-metabolite axis, remain poorly understood. ...
Dual inhibition of PRMT1 and SUV39H1 suppresses breast cancer progression and enhances immunotherapy response [0.03%]
同时抑制PRMT1和SUV39H1可抑制乳腺癌进展并增强免疫治疗效果
Ge Wang,Jiagui Song,Xinwei Duan et al.
Ge Wang et al.
Protein arginine methyltransferase 1 (PRMT1) dysregulation is frequently observed in various human cancers, including breast cancer. However, the antitumor efficacy of PRMT1 inhibitors remains limited in the treatment of breast cancer. Here...
Cholesterol Overload Drives Hepatic Steatosis by Inhibiting OGT-dependent PPARα O-GlcNAcylation and Transactivation [0.03%]
胆固醇过载通过抑制OGT依赖的PPARαO-GlcNA酰化及转激活驱动肝脂肪变性
Rui Guo,Yanhui Li,Qinchao Ding et al.
Rui Guo et al.
Although dietary cholesterol is known to exacerbate liver disease progression, whether and how it contributes to hepatic steatosis, the hallmark early pathological feature of both MASLD and ALD, remains poorly understood. Here, we investiga...
Cancer-associated adipocytes confer CDK4/6 inhibitor resistance in ER+ breast cancer through an IL-6/STAT3/SREBF2 axis coupled with cholesterol metabolism and cell cycle reprogramming [0.03%]
癌症相关脂肪细胞通过IL-6/STAT3/SREBF2轴调节胆固醇代谢和细胞周期重编程赋予ER+乳腺癌CDK4 / 6抑制剂抗性
Renhong Huang,Yiwei Tong,Xi Sun et al.
Renhong Huang et al.
Cancer-associated adipocytes (CAAs) within the tumor microenvironment (TME) critically regulate oncogenic progression. However, the mechanistic basis underlying CAAs-mediated CDK4/6 inhibitor (CDK4/6i) resistance in estrogen receptor-positi...
Targeting SRSF6 to Enhance Cisplatin Sensitivity by Modulating Redox Balance via NFE2L1 exon 4 Splicing in ESCC [0.03%]
靶向SRSF6通过NFE2L1外显子4剪接调节氧化还原平衡以增强食管鳞癌对顺铂的敏感性
Xinyu He,Jialuo Xu,Lina Duan et al.
Xinyu He et al.
The mechanisms by which cancer cells survive and adapt under high levels of reactive oxygen species (ROS) remain poorly understood, especially in the context of redox homeostasis. This study reveals increased oxidative stress in esophageal ...