Targeting FTL regulates ferroptosis and remodels lymph node metastasis microenvironment in esophageal squamous cell carcinoma [0.03%]
靶向FTL调节铁死亡并重塑食管鳞癌淋巴结转移微环境
Shuyue Zheng,Yunzhi Liu,Baifeng Zhang et al.
Shuyue Zheng et al.
More than half of Esophageal squamous cell carcinoma (ESCC) patients are at an advanced stage when first diagnosed, thus they do not benefit much from radical surgery. Single-cell RNA sequencing (scRNA-seq) data from patients with ESCC lymp...
Demystifying metabolic‒immune crosstalk: how amino acid metabolic reprogramming shapes the malignant phenotype and macrophage polarization of biliary and pancreatic tumors [0.03%]
揭秘代谢免疫交互作用：氨基酸的代谢重编对胆道和胰腺肿瘤恶性表型及其巨噬细胞极化的影响
Jinglei Zhang,Zhuohuan Chu,Jiawen Li et al.
Jinglei Zhang et al.
Biliary and pancreatic malignant tumors refer to biliary tract carcinoma (BTC) and pancreatic cancer (PC), among which BTC mainly includes cholangiocarcinoma (CCA) and gallbladder cancer (GBC), and their prognosis is poor because of the lac...
How relevant is the mouse model for understanding human sex determination? [0.03%]
小鼠模型在理解人类性别决定上的相关性有多大？
Francisco Brito,Chloé Mayère,Aurélie Lardenois et al.
Francisco Brito et al.
The mouse is the most widely used model organism for studying mammalian gonadal sex determination and related human disorders. However, a systematic and comprehensive comparison of human and mouse sex determination processes is lacking. Her...
Precision Reprogramming in CAR-T Cell Therapy: Innovations, Challenges, and Future Directions of Advanced Gene Editing [0.03%]
CAR-T细胞治疗中的精准重编程：先进基因编辑的创新、挑战及未来方向
Zimo Jia,Jiajin Wu,Jiyue Zhang et al.
Zimo Jia et al.
Chimeric antigen receptor (CAR)-T cell therapy represents a breakthrough in cancer immunotherapy, demonstrating impressive clinical outcomes, particularly for hematologic malignancies. However, its broader therapeutic application, especiall...
Combination of FTO and BTK inhibitors synergistically suppresses the malignancy of breast cancer cells [0.03%]
FTO和BTK抑制剂联合抑制乳腺癌细胞恶性表型的协同作用研究
Abdulaziz Ahmed A Saad,Lichen Ge,Haoran Wang et al.
Abdulaziz Ahmed A Saad et al.
Despite significant progress in breast cancer treatment, more effective methods for its clinical management are still needed. Our data identified that fat mass and obesity-associated protein (FTO), an N 6-methyladenosine (m6A) demethylase, ...
TGF-β1/SMAD3-mediated Non-canonical Hedgehog Signaling Promotes Pancreatic Stellate Cell Activation and Fibrosis in Chronic Pancreatitis [0.03%]
TGF-β1/SMAD3介导的非经典Hedgehog信号通路促进慢性胰腺炎中胰腺星状细胞活化及纤维化生成
Linrui Peng,Yuchen Hu,Xiaoying Zhang et al.
Linrui Peng et al.
Excessive Hedgehog (Hh) signaling activity contributes to fibrosis in multiple organs. However, its role in pancreatic stellate cell (PSC) activation and fibrosis development during chronic pancreatitis (CP) remains elusive. We show that GL...
α-hederin Targets USP5 to Inhibit Colorectal Tumorigenesis by Disrupting STAT3 Deubiquitination [0.03%]
鹅去氧皮斯替金通过干扰STAT3脱泛素化抑制结直肠肿瘤发生的新靶点USP5
Hui Feng,Qijuan Wang,Liu Li et al.
Hui Feng et al.
α-hederin is a natural compound that is used to treat colorectal cancer (CRC). However, the precise anti-CRC mechanism needs to be explored further, and its direct targets have not yet been reported. In the present study, for the first tim...
Venous Malformations: Unraveling Latest Mechanisms and Bridging Gaps in Targeted Therapy Development [0.03%]
静脉畸形：揭示最新机制及靶向治疗开发中的差距桥梁
Xuan Jiang,Li Hu,Jiayi Lai et al.
Xuan Jiang et al.
The vascular system plays a crucial role in maintaining homeostasis, ensuring the supply of oxygen and nutrients to tissues, while facilitating the removal of metabolic waste. Additionally, it contributes to immune defense, temperature regu...
Synergistic Anti-Tumor Effects of Sulfatinib and Kaempferol on Pancreatic Neuroendocrine Tumors via CALCA-mediated PI3K/AKT/mTOR Pathway [0.03%]
磺达替尼和山柰酚通过CALCA介导的PI3K/Akt/mTOR信号途径协同抑制胰腺神经内分泌肿瘤的作用
Lingyi Chen,Pengfei Liu,Fengjuan Chen et al.
Lingyi Chen et al.
Pancreatic neuroendocrine tumors (pNETs) represent a diverse category of neoplasms originating from pancreatic neuroendocrine cells. Although these tumors generally exhibit a relatively indolent nature, they often metastasize early in their...
CCL2 supports human hepatocytes long-term expansion for bioartificial liver therapy to relieve acute liver failure and extrahepatic complications [0.03%]
CCL2支持人肝细胞长期扩增用于生物人工肝治疗以缓解急性肝衰竭及肝外并发症
Zibin Zhan,Xuewen Liu,Min Zeng et al.
Zibin Zhan et al.
The lack of expandable human hepatocytes in vitro hampers the clinical application of the bioartificial liver. Previous studies have shown that chemical cocktails containing growth factors can support long-term expansion of hepatocytes thro...