Mechanical Microenvironment in Tumor Immune Evasion: Bidirectional Regulation Between Matrix Stiffness and Immune Cells and Its Therapeutic Implications [0.03%]
肿瘤免疫逃逸中的机械微环境：细胞外基质刚度与免疫细胞的相互调控及其治疗意义
Jing Ai,Huayao Li,Minpu Zhang et al.
Jing Ai et al.
Immune evasion remains a major obstacle to effective cancer immunotherapy. While the regulatory mechanisms of the tumor biochemical microenvironment are relatively well-characterized, the role of its mechanical microenvironment-particularly...
The IL-33/ST2 Axis Promotes Traumatic Heterotopic Ossification by Driving Macrophage and Mast Cell-Mediated Inflammation via Autophagy Defects [0.03%]
自噬缺陷通过驱动巨噬细胞和 mast cell介导的炎症促进IL-33 / ST2轴异位骨化
Zhenyu Chen,Yi Xu,Cheng Qu et al.
Zhenyu Chen et al.
Trauma-induced Heterotopic ossification (tHO) is the abnormal osteogenesis occurring in soft tissues after traumatic musculoskeletal injury, which can lead to severe limb movement impairment or even disability. Recent studies have indicated...
Unravelling Resistance: Integrating Metabolism, Epigenetics, Immunology, and Proteostasis in Strategies against Kirsten Rat Sarcoma Viral Oncogene Homolog-mutant Colorectal Cancer [0.03%]
解开耐药性：在克雷顿大鼠肉瘤病毒癌基因同源物突变型结直肠癌策略中的代谢、表观遗传学、免疫学和蛋白质稳态的整合
Jingyi Li,Na Song,Rui Ma et al.
Jingyi Li et al.
Colorectal cancer (CRC) has a high incidence and mortality rate globally, with approximately 40% of patients harboring Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations. Patients with KRAS mutations exhibit poorer prognoses compar...
Circular RNA circPLXNC1 functions as an inhibitor of senescence by regulating autophagy in osteoarthritis [0.03%]
圆环RNA circPLXNC1通过调节自噬在骨关节炎中发挥抗衰老作用
Hongyi Zhou,Zhongyin Ji,Heng Sun et al.
Hongyi Zhou et al.
Objectives: Dysfunctional autophagy during aging is a universal inducer of a variety of degenerative diseases. Here, we aim to identify important non-coding RNAs that are crucial for the regulation of osteoarthritis (OA) and age-associated ...
Piezo1-driven mechanotransduction regulates mitochondrial biogenesis by AMPK/SIRT1-mediated PGC-1α deacetylation to ameliorate bone loss in disuse osteoporosis [0.03%]
Piezo1介导的机械转导通过AMPK/SIRT1依赖性去乙酰化PGC-1α调节线粒体生物合成，缓解失用性骨质疏松症中的骨丢失现象
Jianpeng Chen,Dengying Wu,Chengbin Huang et al.
Jianpeng Chen et al.
Disuse osteoporosis (DOP), a skeletal disorder triggered by insufficient mechanical loading, manifests as progressive bone mass deterioration and microarchitectural weakening. Piezo1, a key mechanosensitive ion channel expressed in bone cel...
The Roles of TOPK in Tumorigenesis and Development: Structure, Mechanisms, Pathways, and Therapeutic Implications [0.03%]
TOPK在肿瘤发生和发展中的作用：结构、机制、通路及治疗意义
Mengyu Zhao,Min Zhang,Mengrui Liang et al.
Mengyu Zhao et al.
TOPK (T-LAK cell-originated protein kinase), also known as PDZ-binding kinase, is a serine/threonine kinase belonging to the mitogen-activated protein kinase family. It is a critical regulator of essential cellular processes, including surv...
PTEN-deficient, chromosomal instability colorectal cancer is hypersensitive to STAT3 inhibition [0.03%]
PTEN缺陷性染色体不稳定型结直肠癌易感STAT3抑制作用
Guowen Ren,Yue Pu,Xiumei Zhang et al.
Guowen Ren et al.
Genetic alterations that induce chromosomal instability (CIN) in colorectal cancer (CRC) cells result in partial impairments in a crucial cellular process, which present an opportunity for therapeutic exploitation in cancer treatment. In ou...
N-Homocysteinylation of HMGB1/2 Promotes Corpus Cavernosum Endothelial Senescence in Erectile Dysfunction [0.03%]
HMGB1/2的S-羟基同型半胱氨酸化促进阴茎海绵体血管内皮细胞衰老在勃起功能障碍中的作用
Peng Hu,Sen Fu,Beining Li et al.
Peng Hu et al.
Homocysteine (Hcy) is an age-related risk factor for erectile dysfunction (ED), with enhanced vascular toxicity in middle-aged and elderly individuals. However, folate-based Hcy-lowering therapies have shown limited efficacy, necessitating ...
GDF15 Drives Glioblastoma Radioresistance by Inhibiting Ferroptosis and Remodeling the Immune Microenvironment [0.03%]
GDF15通过抑制铁死亡和重塑免疫微环境来驱动胶质母细胞瘤的放射抵抗性
Wenqing Feng,Yantan Liu,Qinghua Zhang et al.
Wenqing Feng et al.
Radiotherapy is a primary treatment for glioblastoma (GBM), yet its effectiveness is limited by frequent recurrence due to radioresistance. Our previous studies have illustrated that GDF15 is highly expressed in radioresistant GBM cells and...
SIRT1 in Liver Diseases: Mechanistic Insights and Therapeutic Prospects [0.03%]
肝脏疾病中的SIRT1：机制见解和治疗前景
Fucheng Zuo,Junfa Yang,Qixiang Wu et al.
Fucheng Zuo et al.
Liver diseases present a formidable global health challenge and rank among the leading causes of morbidity and premature mortality worldwide. Silent information regulator 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD⁺)-dependent hist...