Spinal glycine receptor alpha 1 coordinates startle behavior through a cell-type specific mechanism [0.03%]
脊髓甘氨酸受体α1亚型通过特定细胞类型机制调控惊跳反应
Shoupeng Wei,Jiyi Xu,Shao-Rui Chen et al.
Shoupeng Wei et al.
The spinal cord critically regulates startle responses through local excitatory and inhibitory circuits. The glycine receptor alpha 1 subunit (GlyRα1) mediates the primary inhibitory neurotransmission in the spinal cord, however, the contr...
SYNCRIP drives ferroptosis resistance and metabolic activation via SIRT1 and HK2 in glioblastoma [0.03%]
SYNCRIP通过SIRT1和HK2促进胶质母细胞瘤中铁死亡抵抗和代谢激活
Hyeon Ji Kim,Hyo-Jin Song,Yu Gyung Kim et al.
Hyeon Ji Kim et al.
Synaptotagmin-binding cytoplasmic RNA-interacting protein (SYNCRIP) is an RNA-binding protein (RBP) implicated in the pathogenesis of various cancers through involvement in regulating multiple cellular processes. Notably, this study identif...
From Host-Microbiome Symbiosis to Clinical Translation: A Gut Microbiome Perspective on Radiation Enteritis [0.03%]
从宿主微生态共生到临床转化——肠道微生态视角下的放射性肠炎
Jieru Zhuang,Yun Zhong,Zhongyao Lin et al.
Jieru Zhuang et al.
Radiotherapy is an essential component of multimodal treatment for solid tumors, and more than half of patients with cancer receive radiation during their disease course. Because of the unique anatomical and physiological features of the in...
C3G Downregulation Enhances Stemness in Glioblastoma Cells by Promoting PKM2 Upregulation [0.03%]
C3G通过促进PKM2上调来增强胶质母细胞瘤干细胞样特性的调节机制研究
Mateo Cueto-Remacha,Sara Manzano,Minerva Iniesta-González et al.
Mateo Cueto-Remacha et al.
Glioblastoma (GBM), the most common and aggressive primary brain tumor, exhibits profound metabolic reprograming that sustains its progression and therapy resistance. Our previously published work demonstrated that C3G expression is downreg...
High density-lipoprotein regulates liquid-liquid phase separation of heat shock protein β-1 by lncRNA HDRACA to affect vascular inflammation and atherosclerosis [0.03%]
高密度脂蛋白通过长链非编码 RNA HDRACA 调节热休克蛋白β-1的液-液相分离从而影响血管炎症和动脉粥样硬化
Zhi-Wei Mo,Yi-Fang Liu,Yi-Xin Zhang et al.
Zhi-Wei Mo et al.
High-density lipoprotein (HDL) from healthy subjects (HDLhealthy) has anti-inflammatory effects, whereas HDL from patients with coronary artery disease (HDLCAD) is functionally impaired, which may affect atherosclerosis formation differentl...
Targeting Netrin-1 Mediates the Suppression of Osteolytic Bone Metastasis in Breast Cancer by Ugonin L [0.03%]
乌药醇L抑制乳腺癌骨转移的机制研究
Trung-Loc Ho,Wei-Cheng Chen,Chun-Lin Liu et al.
Trung-Loc Ho et al.
Over 70% of patients experience bone metastases, a serious and crippling side effect of breast cancer that increases morbidity. There is an urgent need for innovative therapies because current therapeutic options, including systemic and loc...
Glycosylation of B7-H3 Promotes CD8+ T Cell Exhaustion by Inhibiting the Endosome-Lysosome Pathway in HCC [0.03%]
B7-H3糖基化通过抑制溶酶体途径促进肝癌CD8+T细胞衰竭
Yifan Yu,Jiaxing Liu,Zhixiong Hao et al.
Yifan Yu et al.
A pivotal factor in the immune evasion of hepatocellular carcinoma (HCC) is the excessive exhaustion of CD8+ T cells; however, the molecular drivers of this phenomenon remain incompletely understood. In this study, we discovered that B7-H3 ...
Intestine-specific Faf2 depletion ameliorates obesity and metabolic dysfunction-associated steatotic liver disease by impairing lipid absorption [0.03%]
特异性删除肠Faf2通过损害脂质吸收缓解肥胖和与代谢功能障碍相关的脂肪变性肝病
Jingjing Zhang,Norihiro Imai,Jinglei Cheng et al.
Jingjing Zhang et al.
Fas-associated factor family member 2 (Faf2) is an endoplasmic reticulum (ER)-associated protein implicated in apolipoprotein B (ApoB) metabolism, yet its physiological role in the intestine remains unclear. To investigate this, we generate...
Butyrate enhances tumor immune evasion by increasing PD-L1 abundance [0.03%]
丁酸通过增加PD-L1的含量来增强肿瘤免疫逃逸
Xue Sun,Yi Gao,Jiaxi Li et al.
Xue Sun et al.
As a short-chain fatty acid and histone deacetylase (HDAC) inhibitor, butyrate possesses extensive immunomodulatory properties. Here, we uncover a novel mechanism wherein butyrate markedly upregulates the expression of the immune checkpoint...
HLA class I-specific nucleolin peptides induce therapeutic T cells in triple-negative breast cancer patients [0.03%]
特异性针对HLA-I类的核糖核蛋白P233肽可诱导三阴性乳腺癌患者的治疗性T细胞
Suyanee Thongchot,Niphat Jirapongwattana,Thaweesak Chieochansin et al.
Suyanee Thongchot et al.
Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis and limited treatment options owing to the lack of expression of common therapeutic targets such as hormone receptors and HER2. Recent advances in immunopepti...