SIRT6-Mediated Regulation of TFAM: A Central Mechanism Connecting Nuclear and Mitochondrial Transcriptional Processes and Mitophagy [0.03%]
SIRT6介导的TFAM调节：连接核和线粒体转录过程及自噬的中心机制
Meimei Jiang,Jiehan Li,Ning Ding et al.
Meimei Jiang et al.
Nuclear and mitochondrial transcriptional regulation represent distinct mechanisms of gene expression control, both of which have garnered significant scientific attention. However, the interplay between these two regulatory processes remai...
Therapy-induced mRNA, rRNA and tRNA methylation alterations confer tolerance phenotype in tumor cells: mechanism and implications [0.03%]
化疗诱导的肿瘤细胞mRNA、rRNA和tRNA甲基化改变及其分子机制与生物学意义
Anfeng Jiang,Shujie Liu,Zhiyuan Li et al.
Anfeng Jiang et al.
Drug tolerant persister cells (DTPs) refer to a transient drug-tolerance sub-population of cancer cells characteristics of phenotype plasticity and heterogeneity. This adaptive cell state is a critical transitional phase, standing on the cr...
KRAS-Driven Hypertranscription and Metastatic Dissemination in Colorectal Cancer Could be Overcome by Targeting the NMHC IIA/ PLK1 Signaling Axis with a Novel Acridine Derivative [0.03%]
新型吖啶衍生物通过靶向NMHC IIA / PLK1信号轴克服结直肠癌KRAS驱动的过度转录和转移性播散
Dengbo Ji,Haizhao Yi,Ming Li et al.
Dengbo Ji et al.
Colorectal cancer (CRC) becomes highly lethal upon progression to advanced or metastatic stages. Treatment options are particularly limited for refractory metastatic CRC (mCRC) harboring KRAS mutations. In this study, we established a serie...
Lysophosphatidic acid-induced Arf6-driven macropinocytosis of CD147+ extracellular vesicles promotes sorafenib resistance of hepatocellular carcinoma [0.03%]
溶血磷脂酸通过Arf6介导的巨胞饮作用诱导CD147+细胞外囊泡摄取促进肝癌索拉非尼耐药性
Luomeng Qian,Zhiguang Fu,Ping Chen et al.
Luomeng Qian et al.
Background: Transarterial chemoembolization (TACE) combined with sorafenib is a common therapeutic strategy for hepatocellular carcinoma (HCC). However, sorafenib resistance (SFR) remains a major clinical obstacle. Evidence suggest that TAC...
SLC25A1-Mediated Cholesterol Accumulation Promotes Endometriosis Progression by Enhancing Endometrial Stromal Cell Proliferation, Invasion, and M2 Macrophage Polarization [0.03%]
SLC25A1介导的胆固醇积累通过促进子宫内膜基质细胞增殖、侵袭和M2型巨噬细胞极化来促进子宫内膜异位症的发展
Pusheng Yang,Tao Wang,Yaxin Miao et al.
Pusheng Yang et al.
Endometriosis is an estrogen-dependent chronic inflammatory disorder. Cholesterol (CHO) has been reported to be closely associated with estrogen synthesis and inflammatory responses. Nevertheless, the mechanisms underlying the effects of ch...
Dual-pathway mechanism of vanadium-induced hepatotoxicity in ducks: Synergistic crosstalk between glucose homeostasis disruption and NADH/FSP1/COQ10 axis-driven ferroptosis [0.03%]
钒致鸭肝损伤双重作用机制：糖代谢紊乱与NADH/FSP1/COQ10轴驱动铁死亡的协同对话
Huawei Chen,Xueyan Dai,Zhiwei Xiong et al.
Huawei Chen et al.
In intensive duck production systems, vanadium (V) is widely used as a growth-promoting additive, but excessive supplementation poses health risks to ducks. Previous research indicated that V could cause damage to organs by disrupting the s...
Schisandrin B Targets PXR to Enhance Bile Acid Metabolism and Alleviate ANIT-Induced Cholestatic Liver Injury via Dual Pathways [0.03%]
五味子乙素通过双重途径靶向PXR促进胆汁酸代谢并缓解ANIT诱导的胆汁淤积型肝损伤
Ying Zhang,Huan Lan,Xuechun Yu et al.
Ying Zhang et al.
Cholestatic liver injury (CLI) is a rapid progressive liver disorder characterized by the accumulation of bile acids (BA). Although pregnane X receptor (PXR) is a critical regulator of BA metabolism, the synergistic mechanisms of natural co...
Pan-cancer bone metastasis atlas at single-cell resolution identifies a distinct tumor-associated macrophage subset for mediating Denosumab-induced immunosensitization in lung cancer bone metastasis [0.03%]
泛癌骨转移单细胞图谱鉴定出一种独特的肿瘤相关巨噬细胞亚群可介导Denosumab在肺癌骨转移中诱导免疫增敏作用
Xianglin Hu,Nan Du,Yansha Song et al.
Xianglin Hu et al.
Lung cancer (LC), prostate cancer (PC), and breast cancer (BC) are the three most prevalent cancers that lead to bone metastasis (BoM). In this study, we conducted an integrated analysis of single-cell transcriptomic data from the primary t...
Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys [0.03%]
猴类诱导多能干细胞用于缓解突变TDP-43介导的神经病理损伤
Xichen Song,Caijuan Li,Yang Yang et al.
Xichen Song et al.
Abnormal cytoplasmic accumulation of TAR DNA-binding protein 43 (TDP-43) is a common pathological feature of TDP-43 proteinopathies. Since non-human primate models can better recapitulate this neuropathology than rodents, we used a monkey m...
Gut Microbiota-Driven Pathways Linking Chronic Stress to Tumor Progression [0.03%]
肠道微生物群介导的慢性应激促进肿瘤进展的新机制研究
Qing Li,Siyuan Xia,Xian Zhang et al.
Qing Li et al.
Chronic stress is increasingly recognized as a critical factor influencing tumor progression, but its underlying mechanisms remain incompletely understood. This review examines the role of gut microbiota as a critical mediator linking chron...