Nuclear Mechanotransduction at the Crossroads: How Membrane Receptors Remodel the Perinuclear Cytoskeleton to Drive Cancer and Disease [0.03%]
核机械信号转导的交叉点：膜受体如何重塑细胞核周围骨架以驱动癌症和疾病
Michela Sgarzi,Elisa Montacci,Martina Mazzeschi et al.
Michela Sgarzi et al.
Growing evidence indicates that nuclear architecture is severely altered in many pathological contexts, primarily in cancer, with major implications for chromatin arrangement and, consequently, gene expression. Actin microfilaments located ...
Targeting Ash1L-STING Axis Restores NK Cell Function and Ameliorates Immune-Mediated Bone Marrow Failure Diseases [0.03%]
靶向Ash1l-STING轴改善NK细胞功能并缓解免疫介导的骨髓衰竭性疾病
Nan Song,Yi Cui,Li He et al.
Nan Song et al.
Aplastic anemia (AA) is an immune-mediated bone marrow failure (BMF) syndrome characterized by pancytopenia and bone marrow hypocellularity. While natural killer (NK) cell dysfunction contributes to AA pathogenesis, the epigenetic mechanism...
ACSL5 programs fatty acid metabolism and mitochondrial fitness to sustain pathogenic T cells and exacerbate Sjögren's syndrome [0.03%]
ACSL5通过编程脂肪酸代谢和线粒体健康来维持病理性T细胞并加剧舍格伦综合征
Xinyi Ren,Junhao Yin,Xinyi Ma et al.
Xinyi Ren et al.
Emerging evidence has shown that fatty acid metabolism is closely associated with autoreactive T cells in autoimmunity, but its function in Sjögren's syndrome (SS) is still unclear. Here, we identified acyl-CoA synthetase long-chain family...
Qi-Ren Chen,Timothy W Moural,Fang Zhu
Qi-Ren Chen
The remarkable success of insects is largely due to their capacity to adapt to various environmental stresses. Central to their ability to cope with chemical challenges, cytochrome P450 monooxygenases (P450s) form a highly diversified super...
MTUS2-AS1 suppression promotes DDX5 protein degradation to enhance the sensitivity of PARP inhibitors in BRCA-wild triple negative breast cancer [0.03%]
MTUS2-AS1抑制通过促进DDX5蛋白降解提高BRCA野生型三阴性乳腺癌的PARP抑制剂敏感性
Tao Xu,Junjie Nie,Bei Pan et al.
Tao Xu et al.
Triple-negative breast cancer (TNBC) primarily relies on traditional adjuvant chemotherapy and radiotherapy, which have significant side effects and are prone to drug resistance. Poly ADP-ribose polymerase inhibitor (PARPi) has been approve...
Single-cell atlas of rhesus monkey testis reveals aging- and season-dependent regulation of spermatogenesis and microenvironment homeostasis [0.03%]
食蟹猴单细胞图谱揭示生殖衰老与季节变化对生精过程及微环境稳态的调控
Shengnan Wang,Yichao Wang,Li Wu et al.
Shengnan Wang et al.
Spermatogenesis is a highly orchestrated process that depends on precise coordination between germ cells and the testicular microenvironment. However, how intrinsic aging and seasonal transitions regulate this process in nonhuman primates r...
Immune Imprinting and Antigenic Drift as Determinants of SARS-CoV-2 Vaccine Performance [0.03%]
免疫印迹和抗原漂移作为决定SARS-CoV-2疫苗性能的因素
Seung-Jae Lee,Jaehoon Bae,Sang Hoon Lee
Seung-Jae Lee
The Metabolic-Immune Axis: Amino Acids and Immune Cell Dynamics in Mammary Gland Development and Remodeling [0.03%]
代谢免疫轴：氨基酸和免疫细胞在乳腺发育和重塑中的动态变化
Xiangyang Ye,Ziwei Xu,Yating Chen et al.
Xiangyang Ye et al.
The mammary gland undergoes tightly coordinated cycles of growth, differentiation and regression, which require precise communication between epithelial and stromal cells. Immune cells, whether tissue-resident or recruited, are well-establi...
ALYREF-mediated m5C modification of CCNA1 drives escape from cell-cycle arrest and contributes to pazopanib resistance in Renal Cell Carcinoma [0.03%]
Alyref介导的CCNA1m5C修饰促使肾细胞癌逃避细胞周期阻滞并促进帕唑帕尼耐药性产生
Zeyi Lu,Yang Li,Ziwei Zhu et al.
Zeyi Lu et al.
Pazopanib, a first-line tyrosine kinase inhibitor for advanced renal cell carcinoma (RCC), faces significant clinical limitations due to acquired resistance. In this study, we reveal a novel mechanism underlying pazopanib resistance in RCC,...
Targeting Kupffer Cell CD44-Mediated Ammonia Death via the ELAVL1-GLS Metabolic Circuit in Radiation-Induced Liver Disease [0.03%]
辐照致肝病小鼠枯氏细胞CD44介导的氨诱导死亡通过ELAVL1-GLS代谢通路发生
Yanyan Lin,Shuxuan Wang,Bufu Tang et al.
Yanyan Lin et al.
Radiation-induced liver disease (RILD) remains a major dose-limiting toxicity in liver cancer radiotherapy. However, the underlying mechanisms, particularly the immunometabolic reprogramming that sustains inflammatory amplification followin...