Cardiovascular-related proteomic changes in ECFCs exposed to the serum of COVID-19 patients [0.03%]
COVID-19患者血清暴露对ECFC蛋白组的影响研究
Lucía Beltrán-Camacho,Santosh D Bhosale,Daniel Sánchez-Morillo et al.
Lucía Beltrán-Camacho et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection significantly affects the cardiovascular system, causing vascular damage and thromboembolic events in critical patients. Endothelial dysfunction represents one of the fi...
Recombinant cell-penetrating trichosanthin synergizes anti-PD-1 therapy in colorectal tumor [0.03%]
重组穿膜冬凌草霉素联合抗PD-1治疗结直肠癌研究
Meng Zhang,Ergang Liu,Guihua Chen et al.
Meng Zhang et al.
Alleviating immunosuppression of the tumor microenvironment is an important strategy to improve immune checkpoint therapy. It is an urgent but unmet need to develop adjuvant therapeutics for assisting the mainstay immunotherapies. Trichosan...
Serine/threonine kinase 3 promotes oxidative stress and mitochondrial damage in septic cardiomyopathy through inducing Kelch-like ECH-associated protein 1 phosphorylation and nuclear factor erythroid 2-related factor 2 degradation [0.03%]
丝氨酸/苏氨酸蛋白激酶3通过诱导Kelch-likeECH关联蛋白1磷酸化及核因子E2相关因子2降解促进脓毒症心肌病氧化应激和线粒体损伤
Hang Zhu,Zhe Dai,Xiaoman Liu et al.
Hang Zhu et al.
Serine/threonine kinases (STK3) is a core component of the Hippo pathway and modulates oxidative stress and inflammatory responses in cardiovascular diseases. However, its potential role in septic cardiomyopathy remains undefined. STK3-medi...
Novel Implication of the Basement Membrane for Breast Cancer Outcome and Immune Infiltration [0.03%]
基底膜对乳腺癌预后和免疫浸润的新影响
Wenwen Tian,Yongzhou Luo,Yuhui Tang et al.
Wenwen Tian et al.
Therapeutic failure in breast cancer patients is largely attributed to postoperative advancement and therapy resistance. Nevertheless, an efficacious prognostic signature for recognizing this population is lacking. The basement membrane (BM...
CXCL14 promotes metastasis of non-small cell lung cancer through ACKR2-depended signaling pathway [0.03%]
CXCL14通过ACKR2依赖的信号通路促进非小细胞肺癌转移
Tsung-Ming Chang,Yao-Chang Chiang,Chiang-Wen Lee et al.
Tsung-Ming Chang et al.
Background: Lung cancer is a malignant tumor with metastatic potential. Chemokine ligand 14 (CXCL14) has been reported to be associated with different cancer cell migration and invasion. However, few studies have explored the function of CX...
Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation [0.03%]
鞘氨醇-1-磷酸受体4通过抑制促炎性巨噬细胞活化来缓解实验性哮喘中的中性粒细胞性气道炎症
Shanshan Wang,Zhen Tian,Yanjiao Lu et al.
Shanshan Wang et al.
Patients with eosinophilic asthma react well to conventional treatment of asthma while individualized therapy for non-eosinophilic endotypes have yet to be developed. Dysregulated sphingosine metabolites are associated with the pathophysiol...
APOL3-LDHA axis related immunity activation and cancer ferroptosis induction [0.03%]
APOL3-LDHA轴相关免疫激活和癌症铁死亡诱导
Yuzhao Feng,Yunlu Dai
Yuzhao Feng
Three unconventional maxims in the natural selection of cancer cells: Generation of induced tumor-suppressing cells (iTSCs) [0.03%]
癌细胞自然选择的三个非常规原理：诱导性肿瘤抑制细胞（iTSC）的产生
Kexin Li,Qingji Huo,Bai-Yan Li et al.
Kexin Li et al.
Induced tumor-suppressing cells (iTSCs) can be generated from cancer and non-cancer cells. Here, three paradoxical maxims for the action of iTSCs are reviewed: the secretion of tumor-suppressing proteins, their role as a "double-edged" swor...
Cancer-associated fibroblasts promote migration and invasion of non-small cell lung cancer cells via METTL3-mediated RAC3 m6A modification [0.03%]
METTL3介导的RAC3m6A修饰促进癌相关成纤维细胞分泌因子诱导肺腺癌细胞迁移和侵袭
Mengmeng Chen,Qicheng Zhang,Sijia Zheng et al.
Mengmeng Chen et al.
Cancer progression depends on the communication between tumor cells and tumor microenvironment. Cancer-associated fibroblasts (CAFs) are a major component of stromal cells. CAFs promote cancer metastasis; however, it has not been evaluated ...
IGF2BP3 Regulates TMA7-mediated Autophagy and Cisplatin Resistance in Laryngeal Cancer via m6A RNA Methylation [0.03%]
通过m6A RNA甲基化TMA7介导的自噬调控IGF2BP3在喉癌中的作用
Like Yang,Bingrui Yan,Lingmei Qu et al.
Like Yang et al.
Translation machinery associated 7 homolog (TMA7) is closely related to proliferation-related diseases. However, the function and regulatory mechanism of TMA7 in laryngeal squamous cell carcinoma (LSCC) remain unclear. The present study aim...