The m6A modification-mediated positive feedback between glycolytic lncRNA SLC2A1-DT and c-Myc promotes tumorigenesis of hepatocellular carcinoma [0.03%]
m6A修饰介导的糖酵解长链非编码RNA SLC2A1-DT与c-Myc之间的正反馈促进肝细胞癌的发生进程
Zhu Zeng,Jie Wang,Fengyu Xu et al.
Zhu Zeng et al.
Glycolysis exerts a key role in the metabolic reprogramming of cancer. Specific long non-coding RNAs (lncRNAs) have been identified to exhibit oncogenic glycolysis regulation. Nevertheless, the precise mechanisms by which glycolysis-related...
Inhibition of BRD4 Attenuates ER Stress-induced Renal Ischemic-Reperfusion Injury [0.03%]
BRD4抑制剂可减轻肾缺血再灌注过程中的内质网应激反应
Paula Diaz-Bulnes,Ramon M Rodríguez,Elisenda Banon-Maneus et al.
Paula Diaz-Bulnes et al.
Renal ischemia-reperfusion injury (IRI) leads to endoplasmic reticulum (ER) stress, thereby initiating the unfolded protein response (UPR). When sustained, this response may trigger the inflammation and tubular cell death that acts to aggra...
Interruption of p38MAPK-MSK1-CREB-MITF-M pathway to prevent hyperpigmentation in the skin [0.03%]
阻断p38MAPK-MSK1-CREB-MITF-M通路以防止皮肤色素沉着过度
Song-Hee Kim,Jiyeon Lee,Jihye Jung et al.
Song-Hee Kim et al.
Background: Melanocortin 1 receptor (MC1R), a receptor of α-melanocyte-stimulating hormone (α-MSH), is exclusively present in melanocytes where α-MSH/MC1R stimulate melanin pigmentation through microphthalmia-associated transcription fac...
NK-92MI Cells Engineered with Anti-claudin-6 Chimeric Antigen Receptors in Immunotherapy for Ovarian Cancer [0.03%]
以Claudin-6为靶点的嵌合抗原受体NK-92MI细胞用于卵巢癌免疫治疗研究
Junping Li,Hong Hu,Hui Lian et al.
Junping Li et al.
Background: The application of chimeric antigen receptor (CAR) NK cells in solid tumors is hindered by lack of tumor-specific targets and inefficient CAR-NK cell efficacy. Claudin-6 (CLDN6) has been reported to be overexpressed in ovarian c...
Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1 [0.03%]
Hspb1通过与Anxa2相互作用恢复Prdx1的抗氧化活性从而减轻凋亡和铁死亡来保护严重急性胰腺炎
Jun He,Xuyang Hou,Junyong Wu et al.
Jun He et al.
Acute pancreatitis (AP) is a common abdominal disease that typically resolves on its own, but the mortality rate dramatically increases when it progresses to severe acute pancreatitis (SAP). In this study, we investigated the molecular mech...
The scheme, and regulative mechanism of pyroptosis, ferroptosis, and necroptosis in radiation injury [0.03%]
放射损伤中焦亡、铁死亡和坏死性凋亡的机制及调控方案
Jiaoyang Ning,Liu Chen,Yu Zeng et al.
Jiaoyang Ning et al.
Radiotherapy (RT) stands as the primary treatment for tumors, but it inevitably causes damage to normal cells. Consequently, radiation injury is a crucial consideration for radiation oncologists during therapy planning. Cell death including...
WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives Cellular Senescence by Upregulating IRF8 [0.03%]
WTAP介导的ELF3的N6-甲基腺苷RNA修饰通过上调IRF8驱动细胞衰老
Lei Zhou,Yun Zhong,Fan Wang et al.
Lei Zhou et al.
N6-methyladenosine (m6A), the most prevalent posttranscriptional RNA modification, involved in various diseases and cellular processes. However, the underlying mechanisms of m6A regulation in skin aging are still not fully understood. In th...
Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs [0.03%]
TFEB介导的自噬溶酶体融合受损通过抑制ATP6V0C表达并与SNARE相互作用促进肾小管细胞周期G2/M期阻滞和肾纤维化
Xiang Ren,Jing Wang,Huizhi Wei et al.
Xiang Ren et al.
Increasing evidence suggests that autophagy plays a major role during renal fibrosis. Transcription factor EB (TFEB) is a critical regulator of autophagy- and lysosome-related gene transcription. However, the pathophysiological roles of TFE...
mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice [0.03%]
七氟烷引起的线粒体DNA-cGAS-STING轴依赖的NLRP3炎症小体活化导致小鼠术后认知功能障碍
Nan-Shi-Yu Yang,Wen-Jing Zhong,Han-Xi Sha et al.
Nan-Shi-Yu Yang et al.
The activation of NLRP3 inflammasome in microglia is critical for neuroinflammation during postoperative cognitive dysfunction (POCD) induced by sevoflurane. However, the molecular mechanism by which sevoflurane activates the NLRP3 inflamma...
Impact of KRAS mutation on the tumor microenvironment in colorectal cancer [0.03%]
KRAS突变对结直肠癌肿瘤微环境的影响
Yiru Zhou,Yeye Kuang,Chan Wang et al.
Yiru Zhou et al.
Kirsten rat sarcoma viral oncogene homolog (KRAS) is an oncogene implicated in the pathophysiology of many cancers. Increasing evidence shows that KRAS mutation is correlated with poor prognosis in numerous cancers, including colorectal can...