Sanggenol L Induces Endoplasmic Reticulum Stress and Triggers Cell Apoptosis in Glioblastoma by Binding to BiP [0.03%]
桑根酚L通过与BiP结合诱导胶质母细胞瘤内质网应激和细胞凋亡
Jingyang Xu,Hongbo Chang,Yi Du et al.
Jingyang Xu et al.
Morus alba L. (white mulberry) is a medicinal plant whose extracts possess significant anti-tumor potential. Through screening 59 commercially available mulberry-derived compounds, we identified a small molecule, Sanggenol L (SL), which exh...
HDAC7-Induced Epigenetic Repression Modulates ATF3 Functional Plasticity in Colorectal Cancer Pathogenesis [0.03%]
组蛋白脱乙酰酶7通过表观遗传学抑制调控ATF3在结直肠癌发生中的功能可塑性
Qi Wang,Donglei Ji,Yanjie Jia et al.
Qi Wang et al.
Class IIa histone deacetylase 7 (HDAC7) regulates transcription primarily through scaffolding functions, but its molecular mechanisms in cancer pathogenesis remain incompletely understood. Here, we establish HDAC7 as a key epigenetic regula...
Piezo1 in hypertrophic chondrocytes regulates osteoclastogenesis in endochondral ossification [0.03%]
Piezo1调控软骨内骨化中的破骨细胞生成
Miriam E A Tschaffon-Müller,Astrid Schoppa,Franziska Eckl et al.
Miriam E A Tschaffon-Müller et al.
Ion channels of the Piezo family are key mechanosensors in diverse tissues, including bone. Recent studies have demonstrated that Piezo1 in differentiating chondrocytes is critical for endochondral ossification during bone development and r...
NOP56 Drives Colorectal Cancer Progression by Modulating p53 Acetylation through SIRT1/p300 [0.03%]
NOP56通过SIRT1/p300调节p53乙酰化驱动结直肠癌进展
Ji Eon Park,Chi-Hoon Ahn,Deok Yong Sim et al.
Ji Eon Park et al.
Nucleolar protein 56 (NOP56), a core component of small nucleolar ribonucleoprotein complexes, has been implicated in oncogenesis through the regulation of reactive oxygen species (ROS) homeostasis; however, its role in colorectal cancer (C...
ABHD11-AS1 Suppresses Colorectal Cancer Progression by Disrupting EIF4E-mediated POU2F1 Ubiquitination [0.03%]
ABHD11-AS1通过干扰EIF4E介导的POU2F1泛素化抑制结直肠癌进展
Shizhen Li,Xianjie Jiang,Linda Oyang et al.
Shizhen Li et al.
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, yet the underlying mechanisms driving its progression are not fully elucidated. Long non-coding RNAs (lncRNAs) have recently emerged as key reg...
Bone Marrow-Derived Macrophage NLRP3 Mediates Renal Fibrosis by triggering TGF-β/Smad3-mediated Macrophage-Myofibroblast Transition [0.03%]
骨髓源性巨噬细胞NLRP3通过启动TGF-β/Smad3介导的巨噬细胞肌成纤维细胞转化介导肾纤维化
Wenbiao Wang,Jiaxiao Li,Yu Zhong et al.
Wenbiao Wang et al.
NLRP3 is a well-recognized pro-inflammatory mediator in renal inflammation. Here, we report a new role for NLRP3 in the pathogenesis of renal fibrosis. Using a large-scale single-cell RNA sequencing, we found that NLRP3 is mainly expressed ...
Surfactant Protein B Precursor Inhibit the Progression of Resectable Non-small Cell Lung Cancer by Suppressing eIF4F-mediated Immune Evasion and Cancer Stemness [0.03%]
表面活性蛋白B前体通过抑制eIF4F介导的免疫逃逸和癌症干细胞特性来抑制可手术非小细胞肺癌的发展
Yongheng Wen,Hao Luo,Xintong Ji et al.
Yongheng Wen et al.
Postoperative progression remains a major challenge in resectable non-small cell lung cancer (rNSCLC), but its factors and mechanisms are not fully understood. Here, we found that 34%-43% of rNSCLC patients have lower surfactant protein B p...
A Novel PROTAC Confers a Dual Benefit Against Amyloid and Tau Pathology in Alzheimer's Disease via DAPK1 Degradation [0.03%]
一种新型的靶向嵌合体通过降解DAPK1对阿尔茨海默病产生双重抗淀粉样蛋白和tau病理作用
Ruomeng Li,Jing Yao,Wen Peng et al.
Ruomeng Li et al.
Alzheimer's disease (AD) is a neurodegenerative disorder that is caused by multiple factors, characterized by a progressive decline in cognitive ability, extracellular amyloid-β (Aβ) plaques, and intracellular neurofibrillary tangles comp...
The Role of NADPH Oxidase 4 in Neutrophil-Mediated Immune Escape in Gastric Cancer [0.03%]
NADPH氧化酶4在胃癌中性粒细胞介导的免疫逃逸中的作用
Jinling Jiang,Wenqi Xi,Yanan Zheng et al.
Jinling Jiang et al.
NADPH oxidase 4 (NOX4) transmits electrons for various redox reactions by generating reactive oxygen species (ROS), which are present at high levels in a variety of malignant tumors, including gastric cancer (GC). Nevertheless, the role of ...
Competitive Binding of UBA52 and HOPX Modulates β-catenin Stability in Colorectal Cancer in the Context of High-Iron Intake [0.03%]
铁摄入过量时UBA52与HOPX竞争结合以调节β-连环蛋白稳定性及结直肠癌发生发展中的作用机制研究
Xiangjun Liu,Tong Tang,Xi Wang et al.
Xiangjun Liu et al.
Over-intake of dietary iron and hereditary iron overload are implicated in colorectal cancer (CRC) carcinogenesis, yet the mechanistic basis of how iron-mediated signaling leads to oncogenesis remains enigmatic. Here we demonstrate that hig...