GPX1 expression promotes stemness and aggressiveness in myxoid liposarcomas [0.03%]
GPX1表达促进黏液样脂肪肉瘤的干细胞特性及侵袭性
Carmen Huergo,Juan Tornín,Oscar Estupiñán et al.
Carmen Huergo et al.
The sarcomagenic process initiates when mesenchymal stromal/stem cells (MSCs) or MSC-derived cells undergo tumoral transformation. Besides, sarcoma evolution is partly driven by the emergence of subpopulations of cancer stem cells (CSCs), w...
Mettl1-mediated m7G modification of Fgfr2 regulates osteogenic and chondrogenic differentiation of mesenchymal stem cells [0.03%]
METTL1介导的Fgfr2的m7G修饰调控间充质干细胞成骨和软骨分化
Quanfeng Li,Yunhui Zhang,Pengfei Ji et al.
Quanfeng Li et al.
N7-methylguanosine (m7G) is a prevalent RNA modification and plays fundamental roles in embryonic stem cell self-renewal and differentiation. However, its specific contributions to mesenchymal stem cell differentiation during skeletal devel...
HIF-1-mediated macrophage metabolic reprogramming promotes AKI to CKD transition [0.03%]
低氧诱导因子介导的巨噬细胞代谢重编程促进急性肾损伤向慢性肾脏病进展
Hong Ding,Yan Zhou,Ren-He Zhu et al.
Hong Ding et al.
Macrophage is educated by the tubule epithelial cell with maladaptive repair during the renal maladaptive repair, which is one of the most important characteristic features in acute kidney injury (AKI) to chronic kidney disease (CKD) transi...
Sec10 negatively regulates antiviral immunity by downregulating NRF2-ATF4-RIG-I axis [0.03%]
SEC10通过下调NRF2-ATF4-RIG-I轴负向调控抗病毒免疫反应
Peili Hou,Fuzhen Zhang,Xiaonan Sun et al.
Peili Hou et al.
Sec10, as a central component of the eight-protein exocyst complex, plays a crucial role in the exocytosis. However, its role in antiviral immunity has remained elusive. Here, we discover that Sec10 negatively regulates antiviral immune res...
Pathophysiology, development, and mortality of major non-communicable diseases in metabolic dysfunction-associated steatotic liver disease: A comprehensive review [0.03%]
代谢功能障碍相关肝脂肪变性肝病中主要非传染性疾病的发生发展及死亡率：全面综述
Minjeong Kang,Jihun Song,Eun Seok Kang et al.
Minjeong Kang et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease and metabolic dysfunction-associated fatty liver disease, has emerged as a critical contributor to the global burden of non...
Immunotherapy resistance in MASLD-related hepatocellular carcinoma: special immune microenvironment and gut microbiota [0.03%]
与MASLD相关的肝细胞癌的免疫治疗抵抗：特殊的免疫微环境和肠道微生物群
Jie Jin,Kun Cheng,Mingrui Chen et al.
Jie Jin et al.
Obesity represents a major global public health challenge. Consequently, metabolic dysfunction-associated steatotic liver disease (MASLD) has become the primary driver of chronic liver disease globally and is currently the most rapidly acce...
Bringing p53 Back: A Prion-Powered Attack on Retinoblastoma [0.03%]
利用朊病毒武器对抗视网膜母细胞瘤;bring p53 back: a prion-powered attack on retinoblastoma摘要：张等人。在这里，作者利用p53 prion的特性来重新激活肿瘤抑制因子p53，在某些类型的癌症中它会失效。
Yuyan Ma,Siqi Yan,Weiming You et al.
Yuyan Ma et al.
Retinoblastoma (RB) represents the most common primary intraocular malignancy in children, driving a critical need for innovative, targeted therapies that enhance tumor control while preserving vision. Current chemotherapy regimens, such as...
Osteocytes Produces RANKL Via Wnt-TGFβ Signaling Axis for Osteoclastogenesis [0.03%]
成骨细胞通过Wnt-TGFβ信号轴产生RANKL诱导破骨细胞生成
Yujiao Liu,Lizhou Zhao,Molin Li et al.
Yujiao Liu et al.
Osteocytes are derived from osteoblasts in the mineralized matrix and are the main source of RANKL required for osteoclastogenesis. We initially found osteocytes as central target cells for Wnt/β-catenin signaling that increases RANKL expr...
NR5A2 (located on chromosome 1q32) inhibits ferroptosis and promotes drug resistance by regulating phospholipid remodeling in multiple myeloma [0.03%]
NR5A2通过调节磷脂重塑抑制铁死亡和促进多发性骨髓瘤的耐药性
Panpan Li,Jiadai Xu,Bei Xu et al.
Panpan Li et al.
Multiple myeloma (MM) is a prevalent hematologic malignancy with improved survival rates over recent decades, although still uncurable. MM with chromosome 1q Gain (1q+) are clinically and biologically heterogeneous. In this study, we found ...
PRMT1/PRMT5-Mediated Differential Arginine Methylation of CRIP1 Promotes the Recurrence of Small Cell Lung Cancer after Chemotherapy [0.03%]
脯氨酸残基甲基转移酶PRMT1和PRMT5介导的CRIP1精氨酰甲基化促进小细胞肺癌化疗后的复发
Yu Han,Lie Ma,Xiaolei Zhang et al.
Yu Han et al.
Arginine methylation, a critical epigenetic modification, plays a vital role in tumor initiation and progression; however, the mechanism by which arginine methylation regulates tumor recurrence remains unclear. Here, we found the differenti...