H3K27 Acetylation-driven IGF2BP2 Mutates during the Aging of MSCs, thereby Influencing Osteogenic Differentiation and Bone Aging [0.03%]
组蛋白乙酰化诱导的IGF2BP2在间充质干细胞衰老过程中发生突变，从而影响成骨分化和骨衰老
Zimo Zhou,Kai Kang,Heran Wang et al.
Zimo Zhou et al.
Aging-related bone loss is closely linked to mesenchymal stem cell (MSC) senescence, but the underlying epigenetic mechanisms remain unclear. Here, the role of histone H3 lysine 27 acetylation (H3K27ac) and its downstream target IGF2BP2 in ...
A SENP7-SIRT1-IL-10 Axis Driven by DeSUMOylation Promotes Breg Differentiation and Immune Evasion in Colorectal Cancer [0.03%]
去SUMO化驱动的SENP7-SIRT1-IL-10轴促进结直肠癌Breg分化和免疫逃逸
Yuhan Liao,Xinghua Zhuo,Yuan Huang et al.
Yuhan Liao et al.
Colorectal cancer (CRC) poses a significant global health challenge, yet immune checkpoint blockade (ICB) therapy benefits only a small subset of patients with mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) tumo...
Meox1 Promotes Cardiac Fibrosis and Pathological Remodeling following Myocardial Infarction through Cthrc1/p-Smad2/3 Signaling [0.03%]
心肌梗死后，Meox1通过Cthrc1/p-Smad2/3信号促进心脏纤维化和病理重塑
Mian Zhang,Xiao-Wen Meng,Yu-Fan Yang et al.
Mian Zhang et al.
Aims: Myocardial infarction (MI) induces pathological cardiac fibrosis and ventricular remodeling, which leads to cardiac dysfunction and heart failure. Mesenchyme homeobox 1 (Meox1) was shown to be an essential transcriptional switch in fi...
The Leucine-mTOR-Autophagy Axis in Granulosa Cells Mediates Circadian Disruption-Induced Anovulation [0.03%]
卵泡细胞中的亮氨酸-mTOR-自噬轴介导了生物钟紊乱诱导的无排卵现象
Renke He,Jiaying Mo,Zhongliang Lin et al.
Renke He et al.
Background: Ovulation disorders represent the most common cause of infertility in women. Previous studies have reported that continuous light exposure can induce anovulation. However, the underlying mechanisms remain unclear. Methods: We as...
Loss of FAT1 drives cyclophosphamide resistance in breast cancer via the Wnt/β-Catenin pathway [0.03%]
FAT1丢失通过Wnt / β-catenin途径驱动乳腺癌中环磷酰胺抗性
Lijing Zhong,Dongyan Cao,Chen Zheng et al.
Lijing Zhong et al.
Drug resistance remains a major obstacle to successful chemotherapy, leading to treatment failure and tumor recurrence. Recent studies indicate that mutations in FAT Atypical Cadherin 1 (FAT1) contribute to drug resistance in cancer cells. ...
LAPTM4B Confers Resistance to EGFR-TKIs by Suppressing the Proteasomal Degradation of ATP1A1 in Non-small Cell Lung Cancer [0.03%]
LAPTM4B通过抑制ATP1A1的蛋白酶体降解介导非小细胞肺癌对EGFR-TKIs的耐药性
Dan Liu,Minxia Liu,Dongjin Lv et al.
Dan Liu et al.
Tyrosine kinase inhibitors (TKIs) have transformed the treatment of EGFR-mutant non-small cell lung cancer (NSCLC); however, acquired resistance remains a major clinical challenge. While lysosomes have been implicated in drug resistance, th...
Targeting Myeloid FoxO1 Ameliorates Sepsis-induced Intestinal Injury by Modulating Tim4+ Macrophage Glycolysis [0.03%]
靶向髓系FoxO1通过调节Tim4+巨噬细胞糖酵解缓解脓毒症诱导的肠损伤
Jiali Ni,Ruowen Zhang,Yaqi Pu et al.
Jiali Ni et al.
Intestinal injury in sepsis contributes to life-threatening systemic infections, accompanied by disruptions in macrophage abundance and function. Forkhead Box O1 (FoxO1) is a critical transcription factor involved in regulating inflammatory...
Hepatic Stellate Cell-derived IL-11 Exacerbates Liver Fibrosis via Interplay between HSCs and Macrophages [0.03%]
肝星状细胞衍生的IL-11通过肝星状细胞和巨噬细胞之间的相互作用加剧肝纤维化
Yu Zhang,Fangfang He,Mozi Lei et al.
Yu Zhang et al.
It has been a consensus that hepatic microenvironment composed by the non-parenchymal cells networks play a critical role during liver fibrogenesis, with the crosstalk between hepatic stellate cells (HSCs) and macrophages being of paramount...
Procyanidin Suppresses Tumor Growth by Activating the B-Cell MAPK Pathway through Remodulation of the Gut Microbiota and Metabolites in Hepatocellular Carcinoma [0.03%]
黄酮类化合物通过重塑肠道菌群及代谢物激活B淋巴细胞MAPK信号通路抑制肝癌肿瘤生长
Ran Huo,Chen-Zheng Gu,Yang Liu et al.
Ran Huo et al.
The mortality of hepatocellular carcinoma (HCC) is high. Plant-derived bioactive compounds have emerged as potential therapies for HCC. Procyanidin (PAC) has been shown to possess immune-modulating and anti-tumor properties. However, the ro...
Integrated single-cell transcriptomics and proteomics elucidate the molecular mechanisms and detoxification strategy of rifampicin-induced hepatotoxicity [0.03%]
整合单细胞转录组和蛋白组阐明利福平致肝毒性的分子机制及解毒策略
Junhui Chen,Qian Zhang,Jingnan Huang et al.
Junhui Chen et al.
Rifampicin (RIF), a cornerstone drug in tuberculosis treatment, is associated with hepatotoxicity, which represents a significant adverse effect that frequently causes discontinuation of therapy. However, a comprehensive evaluation of the m...