Oridonin targets PRDX1 to promote apoptosis by inducing ROS-mediated ER stress and modulating autophagy [0.03%]
牻牛儿酮通过诱导ROS介导的内质网应激和调节自噬来靶向PRDX1以促进细胞凋亡
Ziyang Ding,Sisi Wang,Junhui Chen et al.
Ziyang Ding et al.
Oridonin is a bioactive diterpenoid derived from the widely used traditional Chinese medicinal herb Rabdosia rubescens, exhibits broad-spectrum anti-cancer activity, with several derivatives currently in clinical trials. However, the molecu...
Endothelial Senescence-Associated Secretory Signaling Promotes Macrophage Extracellular Traps Formation and Contributes to the Exacerbation of Combined Lung Injury [0.03%]
内皮衰老相关分泌信号促进巨噬细胞胞外陷阱形成并参与加重复合型肺损伤
Wentao Xie,Hongsen Liao,Yali Dai et al.
Wentao Xie et al.
Radiation-induced lung injury (RILI) is a common complication of thoracic radiotherapy and can be critically exacerbated by pre-existing pulmonary inflammation, yet the synergistic mechanisms driving this pathology remain elusive. Using a m...
The Muscle-Liver Immunometabolic Axis in Liver Transplantation: A Decisive Role in Outcomes and Mechanisms [0.03%]
肝脏移植中的肌肝免疫代谢轴：在结局和机制中发挥决定性作用
Zhu Li,Jinyan Chen,Huigang Li et al.
Zhu Li et al.
Liver transplantation has transformed survival for end-stage liver disease, shifting clinical attention from acute rejection to longer-term vulnerability driven by metabolic dysfunction and loss of skeletal-muscle reserve. In this Review, w...
Mechanical stress-induced STAT3/YAP signaling in fibroblasts programs immunosuppressive lymph node remodeling in lung squamous carcinoma [0.03%]
肺癌鳞状细胞癌中机械应力诱导的STAT3/YAP信号调控成纤维细胞重编程免疫抑制淋巴结重塑
Jie Cai,Zhao An,Wei Gao et al.
Jie Cai et al.
Lung squamous cell carcinoma (LUSC) frequently metastasizes to lymph nodes, yet how tumor-intrinsic biomechanical cues influence nodal immune environments remains unclear. Here, we identify solid stress, generated during tumor expansion, as...
VASN Enhances IGF2BP3 Stability via USP10 Deubiquitination to Promote Triple-negative Breast Cancer Paclitaxel Resistance [0.03%]
VASN通过USP10去泛素化增强IGF2BP3稳定性以促进三阴性乳腺癌紫杉醇耐药性
Hao Liu,Zexiu Lu,Maoshan Chen et al.
Hao Liu et al.
Triple-negative breast cancer (TNBC) is an aggressive subtype lacking effective treatment options, and paclitaxel resistance remains a major clinical challenge. This study investigated the role of VASN in mediating paclitaxel resistance in ...
Loss of Alkbh5 enhances AT2 cell differentiation and alveolar repair across diverse injury models via m6A-dependent Areg signaling [0.03%]
ALKBH5缺失通过m6A依赖的Areg信号增强AT2细胞分化和多种损伤模型下的肺泡修复
Jie Lv,Kechen Chen,Xinlong Wang et al.
Jie Lv et al.
Efficient regeneration of the alveolar epithelium is essential for restoring lung function after injury, yet the mechanisms that govern alveolar type II cell (AT2) behavior remain insufficiently defined. Here, we identify the m⁶A RNA demet...
Intracellular PD-L1: Functions, Regulation, and Therapeutic Implications [0.03%]
细胞内PD-L1：功能、调控及治疗意义
Youliang Zhao,Yaqian Qu,Changfu Hao et al.
Youliang Zhao et al.
Programmed death-ligand 1 (PD-L1) has long been characterized as a membrane-bound immune checkpoint ligand that suppresses antitumor immunity through engagement with PD-1 on T cells. This canonical understanding has underpinned the developm...
Exploring Lipid Metabolic Reprogramming: Mechanistic Insights and Implications for Tumor Radiotherapy [0.03%]
探索脂质代谢重组：机制洞察及其对肿瘤放疗的影响
Ruiqiu Zhu,Ying Wan,Jinrong Wei et al.
Ruiqiu Zhu et al.
Lipid metabolic reprogramming plays a crucial role in modulating tumor responses to radiotherapy by influencing radiation-induced oxidative damage, membrane repair, ferroptosis, energy stress, and immune regulation. Within the context of io...
Leonardo Martin,Jure Bohinc,Alessandra Recchia et al.
Leonardo Martin et al.
CRISPR-based genome and epigenome editing technologies have rapidly evolved from programmable nucleases into a diverse therapeutic toolbox encompassing conventional CRISPR systems, base editing, prime editing, RNA targeting, and epigenetic ...
Cleaning, Chasing and Calming: Promising Paradigms of Senotherapy in Aging-Related Diseases [0.03%]
清除、追捕和安抚：抗衰老医学在与年龄有关的疾病中的前景
Shasha Ran,Siyu Zhou,Haotian Ma et al.
Shasha Ran et al.
With the acceleration of global population aging, the pathological accumulation of senescent cells (SnCs) has been confirmed as the core biological mechanism driving multiple aging-related diseases. This article aims to systematically revie...