Justin C St John,Kanokwan Srirattana,Te-Sha Tsai et al.
Justin C St John et al.
In mammalian species, the mitochondrial genome is between 16.2 and 16.7kb in size and encodes key proteins associated with the cell's major energy-generating apparatus, the electron transfer chain. The maternally inherited mitochondrial gen...
Early onset of puberty in cattle: implications for gamete quality and embryo survival [0.03%]
家畜青春期提前到来的影响：对生殖细胞质量及胚胎存活率的影响
D A Kenny,J Heslin,C J Byrne
D A Kenny
Advancing the age at which puberty and subsequent sexual maturation is attained in cattle is central to the reproductive and economic efficiency of both beef and dairy production systems worldwide. Onset of puberty in both male and female c...
J R Roche,C R Burke,M A Crookenden et al.
J R Roche et al.
The transition from pregnancy to lactation (i.e. the transition period) is a time of significant metabolic challenge, with a several-fold increase in a cow's requirement for energy, protein and minerals within days of calving. A successful ...
Transcriptional and epigenetic control of cell fate decisions in early embryos [0.03%]
早期胚胎中细胞命运决定的转录和表观遗传调控
Ramiro Alberio
Ramiro Alberio
Mammalian embryo development is characterised by regulative mechanisms of lineage segregation and cell specification. A combination of carefully orchestrated gene expression networks, signalling pathways and epigenetic marks defines specifi...
Methylation mechanisms and biomechanical effectors controlling cell fate [0.03%]
控制细胞命运的甲基化机制和生物力学效应器
Tiziana A L Brevini,Elena F M Manzoni,Fulvio Gandolfi
Tiziana A L Brevini
Mammalian development and cell fate specification are controlled by multiple regulatory mechanisms that interact in a coordinated way to ensure proper regulation of gene expression and spatial restriction, allowing cells to adopt distinct d...
Post-fertilisation sperm mitophagy: the tale of Mitochondrial Eve and Steve [0.03%]
受精后的精子线粒体自噬：“夏娃”和“史蒂夫”的故事
Peter Sutovsky,Won-Hee Song
Peter Sutovsky
Preformationist William Harvey's proclamation of everything live coming from an egg still holds true for mammalian mitochondria and mitochondrial genes. At fertilisation, mitochondria carried into the oocyte cytoplasm by the spermatozoon ar...
John J Bromfield,Jason A Rizo,Laila A Ibrahim
John J Bromfield
The question of 'how does the allogeneic fetus survive gestation in the face of the maternal immune system?' has yet to be definitively answered. Several acceptable mechanisms exist to facilitate survival of the semi-allogeneic fetus in var...
Jon M Oatley
Jon M Oatley
At the foundation of spermatogenesis are the actions of spermatogonial stem cells (SSCs), and a remarkable feature of these cells is the capacity to regenerate spermatogenesis following transplantation into testes of a recipient male that l...
Martyna Heiligentag,Ursula Eichenlaub-Ritter
Martyna Heiligentag
The formation of high-quality oocytes depends on complex stage-specific interactions between the germ cell and the somatic compartment involving endocrine, paracrine, and autocrine regulation. Cooperativity in bidirectional signalling and m...
Andrés Gambini,Marc Maserati
Andrés Gambini
Interest in equine somatic cell nuclear transfer technology has increased significantly since the first equid clones were produced in 2003. This is demonstrated by the multiple commercial equine cloning companies having produced numerous cl...