T Komori
T Komori
Since glucocorticoids remain an effective therapeutic option for the treatment of many inflammatory and autoimmune diseases, glucocorticoid-induced osteoporosis is the most common form of secondary osteoporosis. Fractures may occur in as ma...
Abnormal Proteoglycan Synthesis Due to Gene Defects Causes Skeletal Diseases with Overlapping Phenotypes [0.03%]
由于基因缺陷导致的软骨素硫酸化异常与骨骼疾病中重叠表型的关系研究
F Taylan,O Mäkitie
F Taylan
In recent years, massively parallel sequencing technologies have helped us to identify novel disease genes and solve the mysteries behind rare diseases. Today, we know that some diseases with many overlapping and distinct clinical features,...
Bone Marrow Stromal Stem Cells in Tissue Engineering and Regenerative Medicine [0.03%]
骨髓stromal干细胞在组织工程与再生医学中的应用
A Polymeri,W V Giannobile,D Kaigler
A Polymeri
Bone marrow stromal stem cells (BMSCs) are adult multipotent cells, which have the potential to differentiate into cell types of mesodermal origin, namely osteocytes, adipocytes, and chondrocytes. Due to their accessibility and expansion po...
M T Collins,C A Stratakis
M T Collins
PRKACA Mutations in Adrenal Adenomas: Genotype/Phenotype Correlations [0.03%]
肾上腺腺瘤中的PRKACA基因突变及其表型特征分析
G D Dalmazi,F Beuschlein
G D Dalmazi
Untargeted, next generation sequencing approaches have provided deep insights into genetic events that result in unopposed steroidogenesis from the adrenal cortex. In particular, somatic mutations in the gene encoding the catalytic subunit ...
M Haidar,G Ramdani,E J Kennedy et al.
M Haidar et al.
The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such, PKA is involved in the control of a wide variety of cellular proce...
Parathyroid Hormone Polymorphism RS6254 is Associated with the Development and Severity of Osteoporosis in Asymptomatic but not Normocalcemic Hyperparathyroidism [0.03%]
甲状旁腺素多态性RS6254与无症状但非血钙正常的继发性甲状旁腺功能亢进症的发病及严重程度相关
G Díaz-Soto,E Romero,J L Pérez-Castrillón et al.
G Díaz-Soto et al.
Tumor Necrosis Factor-α is Inversely Related to Free Thyroxine in Euthyroid Subjects Without Diabetes [0.03%]
肿瘤坏死因子-α与非糖尿病患者的正常甲状腺素呈负相关关系
L J N van Tienhoven-Wind,R P F Dullaart
L J N van Tienhoven-Wind
Lower thyroid functional status within the euthyroid range may confer increased atherosclerosis susceptibility, as evidenced by increased intima media thickness and coronary artery calcification. Associations of lower thyroid functional sta...
C S Martins,R C Camargo,F P Saggioro et al.
C S Martins et al.
In pituitary tumors, P27(CDKN1B) is underexpressed. We aimed to clarify whether translational regulation underlies this phenomenon. This study evaluated the expression of P27/CDKN1B, its targets (CCNE1, CDK2) and translational regulators (D...
Effects of Quercetin on Adiponectin-Mediated Insulin Sensitivity in Polycystic Ovary Syndrome: A Randomized Placebo-Controlled Double-Blind Clinical Trial [0.03%]
槲皮素对多囊卵巢综合征患者脂联素介导的胰岛素敏感性影响的随机双盲对照临床试验
N Rezvan,A Moini,L Janani et al.
N Rezvan et al.
Polycystic ovary syndrome (PCOS) is a heterogeneous, multi-causal, and genetically complex disorder, which is related to the failure in endocrine glands. Adiponectin has been reported to be low in PCOS, even in the absence of adiposity. Que...