Diana Cozma,Panagiota Siatra,Stefan R Bornstein et al.
Diana Cozma et al.
Metabolic diseases are prevalent in modern society and have reached pandemic proportions. Metabolic diseases have systemic effects on the body and can lead to changes in the neuroendocrine stress axis, the critical regulator of the body's s...
Animal and Cell Culture Models of PPGLs - Achievements and Limitations [0.03%]
PPGL的动物和细胞培养模型 - 成就与局限性
Bhargavi Karna,Natalia Simona Pellegata,Hermine Mohr
Bhargavi Karna
Research on rare tumors heavily relies on suitable models for basic and translational research. Paragangliomas (PPGL) are rare neuroendocrine tumors (NET), developing from adrenal (pheochromocytoma, PCC) or extra-adrenal (PGL) chromaffin ce...
Quantitative Characterization of Ectopic Adrenal Gene Expression in Fetal Testes in 21-Hydroxylase Deficient Mice [0.03%]
21-羟基化酶缺乏的小鼠胎儿睾丸中肾上腺异位基因表达的定量分析
Maximilian Weniger,Maria Mattes,Thomas G P Grünewald et al.
Maximilian Weniger et al.
Testicular adrenal rest tumors (TART) are a frequent and fertility impairing long-term complication in males with classic congenital adrenal hyperplasia. Due to lack of clear experimental data on their origin, they are hypothesized to be de...
Transition from Paediatric to Adult Care in CAH: 20 Years of Experience at a Tertiary Referral Center [0.03%]
从儿科到成人护理的过渡在CAH中：三级转诊中心20年的经验
Cordula Kiewert,Julia Jedanowski,Berthold P Hauffa et al.
Cordula Kiewert et al.
Transition medicine aims at the coordinated transfer of young patients with a chronic disease from paediatric to adult care. The present study reflects 20 years of experience in transitioning patients with congenital adrenal hyperplasia (CA...
The Adrenal Gland: A Fascinating Object of Research and Clinical Care Showcased at the 15th German Adrenal Conference in Dresden [0.03%]
肾上腺：一项令人着迷的研究和临床护理对象在德累斯顿第十五届德国肾上腺会议上展示
Matthias Kroiss,Nicole Bechmann
Matthias Kroiss
Dear colleagues,When younger fellows ask for guidance on how to choose a research project, many aspects require consideration: how to select a supervisor and mentor, should one change the institution, how does the project boost the later pr...
The N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan Improves Glucose Homeostasis and Preserves Pancreatic Islets in NOD Mice [0.03%]
N-甲基-D-天冬氨酸受体拮抗剂右美沙芬改善NOD小鼠的血糖稳态并保护胰岛
Laura Wörmeyer,Oliver Nortmann,Anna Hamacher et al.
Laura Wörmeyer et al.
For treatment of type 1 diabetes mellitus, a combination of immune-based interventions and medication to promote beta-cell survival and proliferation has been proposed. Dextromethorphan (DXM) is an N-methyl-D-aspartate receptor antagonist w...
Utility of Simple and Non-Invasive Strategies Alternative to Inferior Petrosal Sinus Sampling and Peripheral CRH Stimulation in Differential Diagnosis of ACTH-Dependent Cushing Syndrome [0.03%]
在ACTH依赖性库欣综合征鉴别诊断中简单非侵入性的垂体采样和外周CRH刺激的替代策略的有效性研究
Bhawna Attri,Alpesh Goyal,Mani Kalaivani et al.
Bhawna Attri et al.
We aimed to evaluate the utility of simple, cost-effective, and non-invasive strategies alternative to BIPSS and peripheral CRH stimulation in differential diagnosis of ACTH-dependent CS. First, we performed ROC analysis to evaluate the per...
Identification of Key Genes and Related Drugs of Adrenocortical Carcinoma by Integrated Bioinformatics Analysis [0.03%]
整合生物信息学分析识别肾上腺皮质癌的关键基因和相关药物
Jian-Bin Wei,Xiao-Chun Zeng,Kui-Rong Ji et al.
Jian-Bin Wei et al.
Adrenocortical carcinoma (ACC) is a malignant carcinoma with an extremely poor prognosis, and its pathogenesis remains to be understood to date, necessitating further investigation. This study aims to discover biomarkers and potential thera...
Expression and Role of PDK4 on Childhood Dyslipidemia and Lipid Metabolism in Hyperlipidemic Mice [0.03%]
PDK4在儿童血脂异常及高脂血症小鼠血脂代谢中的表达与作用
Wenjuan Cai,Xin Wang,Qian Deng et al.
Wenjuan Cai et al.
Hyperlipidemia is a common metabolic disorder that can lead to cardiovascular disease. PDK4 is a key enzyme that regulates glucose and fatty acid metabolism and homeostasis. The aim of this study is to explore the correlation between PDK4 e...
Revealing Melatonin's Mysteries: Receptors, Signaling Pathways, and Therapeutics Applications [0.03%]
揭秘褪黑素之谜：受体、信号通路及治疗应用
Kulsoom Kulsoom,Wajahat Ali,Zainab Saba et al.
Kulsoom Kulsoom et al.
Melatonin (5-methoxy-acetyl tryptamine) is a sleep-inducing hormone, and the pineal gland produces it in response to the circadian clock of darkness. In the body, MT1 and MT2 receptors are mostly found, having an orthosteric pocket and liga...