C S Martins,R C Camargo,F P Saggioro et al.
C S Martins et al.
In pituitary tumors, P27(CDKN1B) is underexpressed. We aimed to clarify whether translational regulation underlies this phenomenon. This study evaluated the expression of P27/CDKN1B, its targets (CCNE1, CDK2) and translational regulators (D...
Effects of Quercetin on Adiponectin-Mediated Insulin Sensitivity in Polycystic Ovary Syndrome: A Randomized Placebo-Controlled Double-Blind Clinical Trial [0.03%]
槲皮素对多囊卵巢综合征患者脂联素介导的胰岛素敏感性影响的随机双盲对照临床试验
N Rezvan,A Moini,L Janani et al.
N Rezvan et al.
Polycystic ovary syndrome (PCOS) is a heterogeneous, multi-causal, and genetically complex disorder, which is related to the failure in endocrine glands. Adiponectin has been reported to be low in PCOS, even in the absence of adiposity. Que...
D Calebiro,K Bathon,I Weigand
D Calebiro
Somatic mutations in PRKACA, coding for the catalytic α subunit of protein kinase A (PKA), have been recently identified as the most frequent genetic alteration in cortisol-secreting adrenocortical adenomas, which are responsible for adren...
Elevated Steroid Hormone Production in the db/db Mouse Model of Obesity and Type 2 Diabetes [0.03%]
肥胖及2型糖尿病小鼠模型中类固醇激素产生的增加
Anja Hofmann,Mirko Peitzsch,Coy Brunssen et al.
Anja Hofmann et al.
Obesity and type 2 diabetes have become a major public health problem worldwide. Steroid hormone dysfunction appears to be linked to development of obesity and type 2 diabetes and correction of steroid abnormalities may offer new approaches...
Effects of Metformin on Endocrine and Metabolic Parameters in Patients with Polycystic Ovary Syndrome [0.03%]
二甲双胍对多囊卵巢综合征患者内分泌及代谢参数的影响分析
M Zahra,M Shah,A Ali et al.
M Zahra et al.
The present study was designed to evaluate the effects of metformin on metabolic and endocrine parameters in patients with polycystic ovary syndrome (PCOS). The study included 40 patients with PCOS. Patients were divided into 2 groups based...
Salivary Cortisol and Cortisone do not Appear to be Useful Biomarkers for Monitoring Hydrocortisone Replacement in Addison's Disease [0.03%]
唾液皮质醇和皮质osterone似乎不是用于监测阿狄森病氢化可的松替代疗法的有用生物标志物
I L Ross,M Lacerda,T S Pillay et al.
I L Ross et al.
Salivary cortisol has been used to monitor hydrocortisone replacement in patients with Addison's disease (AD). Since salivary cortisol is metabolised to salivary cortisone, it may be an adjunctive analyte to assess adequacy of hydrocortison...
Long-Term Follow-Up and Treatment of Postoperative Permanent Hypoparathyroidism in Patients with Medullary Thyroid Carcinoma: Differences in Complete and Partial Disease [0.03%]
分化型和未分化型甲状腺髓样癌术后永久性低钙血症的长期随访及治疗体会
G Leidig-Bruckner,T Bruckner,F Raue et al.
G Leidig-Bruckner et al.
This study aimed to identify factors influencing long-term outcome in complete or partial postoperative hypoparathyroidism (parathyroid hormone ≤10 or >10 ng/l, respectively) in medullary thyroid carcinoma (MTC). It was designed as retrosp...
Genetic Expression Profile of Vitamin D Metabolizing Enzymes in the First Trimester [0.03%]
维生素D代谢酶的一季度基因表达谱
L Ekström,L Storbjörk,L Björkhem-Bergman
L Ekström
The aim of this study was to map the genetic expression of the vitamin D metabolizing enzymes CYP27A, CYP27B1, CYP2R1, and CYP24A1 in the first trimester in different human fetal tissues. In addition, the gene expression was correlated with...
Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes [0.03%]
神经活性类固醇在急性缺血性卒中患者中的认知、功能和神经预后中的作用关系研究
Sebastian Casas,Maria Claudia Gonzalez Deniselle,Gisella M Gargiulo-Monachelli et al.
Sebastian Casas et al.
Despite several scientific and technological advances, there is no single neuroprotective treatment that can reverse the brain damage after acute ischemic stroke (AIS). Neuroactive steroids are cholesterol-derived hormones that have the abi...
The Complex GNAS Imprinted Locus and Mesenchymal Stem Cells Differentiation [0.03%]
GNAS基因印记位点与间充质干细胞分化之间的关系
F M Elli,V Boldrin,A Pirelli et al.
F M Elli et al.
All tissues and organs derive from stem cells, which are undifferentiated cells able to differentiate into specialized cells and self-renewal. In mammals, there are embryonic stem cells that generate germ layers, and adult stem cells, which...