Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory [0.03%]
成瘾的神经环路动力学：奖赏、反奖赏和情绪记忆
G F Koob
G F Koob
Drug addiction is conceptualized as chronic, relapsing compulsive use of drugs with significant dysregulation of brain hedonic systems. Compulsive drug use is accompanied by decreased function of brain substrates for drug positive reinforce...
F Tretter,P J Gebicke-Haerter
F Tretter
Molecular biology as a research approach in psychiatry has gathered a huge amount of data that can hardly be used for explanation of mental disorders by cellular dysfunctions. In a philosophical sense "explanation" means the application of ...
S H Ahmed,M Graupner,B Gutkin
S H Ahmed
To increase our understanding of drug addiction--notably its pharmacological and neurobiological determinants--researchers have begun to formulate computational models of drug self-administration. Currently, one can roughly distinguish betw...
Intermittent adaptation. A theory of drug tolerance, dependence and addiction [0.03%]
间断适应：一种药物耐受性、依赖性和上瘾的理论
A Peper
A Peper
A mathematical model of drug tolerance and its underlying theory is presented. The model is essentially more complex than the generally used model of homeostasis, which is demonstrated to fail in describing tolerance development to repeated...
Interactive molecular networks obtained by computer-aided conversion of microarray data from brains of alcohol-drinking rats [0.03%]
计算机辅助微阵由酒精消耗大鼠脑获得的交互分子网络数据转换
F Matthäus,V A Smith,A Fogtman et al.
F Matthäus et al.
Lists of differentially expressed genes in a disease have become increasingly more comprehensive with improvements on all technical levels. Despite statistical cutoffs of 99% or 95% confidence intervals, the number of genes can rise to seve...
Comparative Study
Pharmacopsychiatry. 2009 May:42 Suppl 1:S118-28. DOI:10.1055/s-0029-1216348 2009
A Marin-Sanguino,R C H del Rosario,E R Mendoza
A Marin-Sanguino
Most bioscientists engage in informal modelling in their research and explicitly document this activity's results in diagrams or "concept maps". While canonical modelling approaches such as Biochemical Systems Theory (BST) immediately allow...
F Tretter,P J Gebicke-Haerter,M Albus et al.
F Tretter et al.
The onset of addiction is marked with drug induced positive experiences that keep being repeated. During that time, adaptation occurs and addiction is stabilized. Interruption of those processes induces polysymptomatic withdrawal syndromes....
S Bleich,T Hillemacher
S Bleich
The emerging research on biomarkers in alcohol dependence has lead to a deeper understanding of the neurobiological mechanisms in alcoholism. The molecular networks and the pathophysiological circuits are complex and not completely unreveal...
F Tretter,P J Gebicke-Haerter,A Heinz
F Tretter