J Best,M Reed,H F Nijhout
J Best
Mathematical models of dopaminergic and serotonergic synapses have enabled the authors to study quantitative aspects of the synthesis, release and reuptake of dopamine and serotonin, to investigate the effects of autoreceptors, and to explo...
B Dulam-Banawa,A Marin-Sanguino,E Mendoza
B Dulam-Banawa
We review the evolution of synapse models over the last sixty-five years in terms of the changing paradigms: initially, the synapse was modelled only as part of a neuronal system, both as a number (weight of an edge in a connectionist netwo...
Dopamine release in the prefrontal cortex and striatum: temporal and behavioural aspects [0.03%]
前额叶皮层和纹状体多巴胺释放的时空及行为学特征研究
W Hauber
W Hauber
Dopamine (DA) neurons originating in the substantia nigra and ventral tegmental area project to a variety of forebrain structures thereby forming a complex neuromodulatory system that is essential for numerous motor, cognitive and motivatio...
G Birke,A Draguhn
G Birke
Synaptic inhibition can be viewed as a counterbalance of synaptic excitation. However, multiple recent studies at the cellular and network level show that inhibition serves a variety of additional, highly specific functions in the mammalian...
Perspectives of a systems biology of the synapse: how to transform an indefinite data space into a model? [0.03%]
从系统生物学角度看待突触：如何将不确定数据转变为模型？
H W Mewes,B Wachinger,V Stümpflen
H W Mewes
Understanding the synapse and its role in the development of psychiatric disorders is not only a demanding but a highly relevant challenge for neuroscience. With the advancement of modern high-throughput technologies, the amount of data col...
F Tretter,D Rujescu,O Pogarell et al.
F Tretter et al.
F Yagmur,H B Ulusoy,H Buyukoglan et al.
F Yagmur et al.
Case Reports
Pharmacopsychiatry. 2010 May;43(3):118-9. DOI:10.1055/s-0029-1242822 2010
The number needed to treat for all-cause medication discontinuation in the treatment of schizophrenia: consistency across world geographies and study designs [0.03%]
所有原因导致的停药治疗精神分裂症的需要治疗人数（NNT）：全球地理区域和研究设计的一致性分析
D Novick,H Ascher-Svanum,B Zhu et al.
D Novick et al.
Introduction: The number needed to treat (NNT) for all-cause medication discontinuation in large, industry-sponsored, non-randomized, observational studies conducted across world geographies was compared with NNTs from CA...
Comparative Study
Pharmacopsychiatry. 2010 May;43(3):81-5. DOI:10.1055/s-0029-1242816 2010
Serum concentrations, therapeutic response and side effects in children and adolescents with impulsive-aggressive symptoms during risperidone therapy [0.03%]
利培酮治疗儿童和青少年冲动攻击症状的血药浓度、疗效及副作用关系研究
K Klampfl,R Taurines,A Preuss et al.
K Klampfl et al.
Introduction: The aim of this prospective naturalistic study was to examine for the first time the relationship between dosage, serum concentration and clinical outcome in children and adolescents with impulsive-aggressiv...
Multicenter Study
Pharmacopsychiatry. 2010 Mar;43(2):58-65. DOI:10.1055/s-0029-1239540 2010