A Trajectory of Long-Term Antipsychotic Medication Dosage in Inpatients with Severe Behavioral and Psychological Symptoms of Dementia: A Retrospective Study [0.03%]
重症行为和心理症状痴呆住院患者长期抗精神病药物剂量轨迹：一项回顾性研究
Teruo Tada,Takefumi Suzuki,Yusuke Iwata et al.
Teruo Tada et al.
Introduction: While antipsychotics are often prescribed for behavioral and psychological symptoms of dementia (BPSD), typically on an off-label basis, these medications have serious adverse effects. This study investigate...
Integrative Genetic Variation, DNA Methylation, and Gene Expression Analysis of Escitalopram and Aripiprazole Treatment Outcomes in Depression: A CAN-BIND-1 Study [0.03%]
escitalopram和aripiprazole治疗抑郁症结局的整合遗传变异、DNA甲基化和基因表达分析：CAN-BIND-1研究
Farhana Islam,Amanda Lisoway,Edward S Oh et al.
Farhana Islam et al.
Introduction: Little is known about the interplay between genetics and epigenetics on antidepressant treatment (1) response and remission, (2) side effects, and (3) serum levels. This study explored the relationship among...
Management of Refractory Functional Gastrointestinal Disorders: What Role Should Psychiatrists Have? [0.03%]
难治性功能性胃肠病的管理：精神科医生应发挥什么作用？
Mohsen Khosravi,Abdullah A Alzahrani,Thikra M Muhammed et al.
Mohsen Khosravi et al.
Currently, it has been stated that psychiatric and psychological problems are equally paramount aspects of the clinical modulation and manifestation of both the central nervous and digestive systems, which could be used to restore balance. ...
Discontinuation Rate of Lurasidone and Quetiapine Extended Release in Bipolar Depression [0.03%]
鲁拉西 tone和喹硫平缓释片治疗双相抑郁的停药率
Taro Kishi,Kenji Sakuma,Shun Hamanaka et al.
Taro Kishi et al.
Introduction: Lurasidone (LUR) was compared with quetiapine extended release (QUE-ER) regarding 1-year discontinuation in patients with bipolar depression (n=317). ...
Kirsten R Müller-Vahl,Georg Juckel
Kirsten R Müller-Vahl
Advancements in Non-Dopaminergic Treatments for Schizophrenia: A Systematic Review of Pipeline Developments [0.03%]
精神分裂症非多巴胺能治疗的进展：系统评价管道发展的趋势
Yuki Komatsu,Moe Takehara,Xenia Hart et al.
Yuki Komatsu et al.
Introduction: Conventional antipsychotic drugs that attenuate dopaminergic neural transmission are ineffective in approximately one-third of patients with schizophrenia. This necessitates the development of non-dopaminerg...
Viktória Meszár,Gabriella Magyar,Gabriella Mészárosné Pásztor et al.
Viktória Meszár et al.
Introduction: Cariprazine is an atypical dopamine receptor partial agonist antipsychotic available in the form of capsules. Although capsules are one of the most desirable routes of administration, there are certain situa...
Clinical Trial
Pharmacopsychiatry. 2024 Jul;57(4):180-185. DOI:10.1055/a-2291-7130 2024
Pentoxifylline as a Novel Add-on Therapy for Major Depressive Disorder in Adult Patients: A Randomized, Double-Blind, Placebo-Controlled Trial [0.03%]
匹诺卡品作为成人抑郁症增效治疗的新药 III 期随机双盲安慰剂对照试验
Talar A Merza Mohammad,Tavgah A Merza Mohammad,Dyar M Salman et al.
Talar A Merza Mohammad et al.
Background: Evidence indicates an association between immune dysregulation and major depressive disorder (MDD). Pentoxifylline (PTX), a phosphodiesterase inhibitor, has been shown to reduce pro-inflammatory activities. Th...
Randomized Controlled Trial
Pharmacopsychiatry. 2024 Jul;57(4):205-214. DOI:10.1055/a-2291-7204 2024
Risk Phenotypes, Comorbidities, Pharmacotherapy, and Electroconvulsive Therapy (ECT) in a Cohort with Difficult-to-Treat Depression in Comparison to an Unmedicated Control Group [0.03%]
难治性抑郁患者的危险表型、共病、药物治疗和电休克治疗与其未用药对照组的比较研究
Hannah B Maier,Anton Borchert,Alexandra Neyazi et al.
Hannah B Maier et al.
Background: Approximately 15-25% of depressed patients suffer from difficult-to-treat depression (DTD). Patients with DTD require a thorough examination to avoid the oversight of treatable (psychiatric/somatic) comorbidit...
Blood Cell Count Ratios at Baseline are Associated with Initial Clinical Response to Clozapine in Treatment-Resistant, Clozapine-Naïve, Schizophrenia-Spectrum Disorder [0.03%]
基线血细胞计数比值与难治性精神分裂症谱系障碍氯氮平初治的初始临床反应有关
Vicent Llorca-Bofí,Miquel Bioque,Santiago Madero et al.
Vicent Llorca-Bofí et al.
Background: Clozapine is the recommended treatment for managing treatment-resistant schizophrenia (TRS), and immunological mechanisms may be involved in its unique antipsychotic efficacy. This study investigated whether b...