Serum concentrations of citalopram--dose-dependent variation in R- and S-enantiomer ratios [0.03%]
盐酸西汀普拉姆的血浓度-剂量对其R、S两个对映体比率的影响
L Tanum,L P Strand,H Refsum
L Tanum
Introduction: The antidepressive effect of racemic citalopram (CIT) is exerted by S-CIT, while R-CIT is a partial antagonist to S-CIT. Since R-and S-CIT are metabolized by different pathways, we investigated whether the r...
Mental illness, synapses and the brain--behavioral disorders by a system of molecules within a system of neurons? [0.03%]
精神疾病、突触和大脑——分子系统内的神经元系统的紊乱导致行为异常？
F Tretter
F Tretter
The multi-level systems view conceiving the brain as a "network of networks of neurons" rises the question how it could be possible to understand this complex system with respect to mental functions and dysfunctions. One crucial issue is re...
S Postnova,E Rosa Jr,H A Braun
S Postnova
We propose a mechanism-based modelling approach which brings together the most relevant features of neural dynamics and synaptic transmission for clinically valuable simulations of psychiatric disorders and their pharmaceutical treatment. I...
H Liljenström
H Liljenström
In this paper, we use computational models of varying complexity to investigate the role of synaptic modifications for cortical network properties. In particular, we study how the dynamics can be regulated by neuromodulators, intrinsic nois...
Computational modeling of synaptic neurotransmission as a tool for assessing dopamine hypotheses of schizophrenia [0.03%]
计算模型在突触神经传导中的应用及其在评估精神分裂症多巴胺假说方面的价值
Z Qi,G W Miller,E O Voit
Z Qi
Schizophrenia is a severe and complex mental disorder that causes an enormous societal and financial burden. Following the identification of dopamine as a neurotransmitter and the invention of antipsychotic drugs, the dopamine hypothesis wa...
C-C Chen,Y-Y Chen,G C L Hung
C-C Chen
Case Reports
Pharmacopsychiatry. 2010 Jul;43(5):200-1. DOI:10.1055/s-0030-1249094 2010
Allopurinol for treatment-resistant schizophrenia and epilepsy: a case report [0.03%]
治疗抗精神病药抵抗的精神分裂症和癫痫的别嘌呤醇：一例报告
C-S Liang,F-W Yang,K-T Chiang et al.
C-S Liang et al.
Case Reports
Pharmacopsychiatry. 2010 Aug;43(6):233-4. DOI:10.1055/s-0030-1254092 2010
Transitions from General Practitioner to Psychiatrist Care (or vice versa) during a first antidepressant treatment episode [0.03%]
抗抑郁药首次治疗期间从全科医生转至精神科医师(或相反方向)诊疗
H Gardarsdottir,A C G Egberts,E R Heerdink
H Gardarsdottir
Introduction: The aim of this study was to investigate how frequently patients transit from general practitioner (GP) to psychiatrist care and vice versa during a first antidepressant episode and antidepressant treatment ...
Finasteride treatment inhibits adult hippocampal neurogenesis in male mice [0.03%]
非那雄胺抑制小鼠成人海马神经发生的作用
B Römer,N Pfeiffer,S Lewicka et al.
B Römer et al.
Introduction: The 5-alpha-reductase inhibitor finasteride is used for the treatment of androgenic alopecia, benign prostate hyperplasia and prostate cancer. Besides inhibiting the conversion of testosterone to the biologi...
Pathological effects of cortical architecture on working memory in schizophrenia [0.03%]
皮层结构对精神分裂症工作记忆的病理影响
C D Gore,M Bányai,P J Gray et al.
C D Gore et al.
Neural connectivity of the prefrontal cortex is essential to working memory. Reduction of prefrontal connectivity and abnormal prefrontal dopamine modulation are common characteristics associated with schizophrenia. Two experiments separate...
Comparative Study
Pharmacopsychiatry. 2010 May:43 Suppl 1:S92-7. DOI:10.1055/s-0030-1251979 2010