Investigation of Stress-Induced Cortisol Effects on Decision Making After Pharmacological Mineralocorticoid or Glucocorticoid Receptor Blockade [0.03%]
药物阻断盐皮质激素受体或糖皮质激素受体对压力诱导皮质醇影响决策的作用研究
Christian E Deuter,Theresa-Svea Weiß,Linn K Kuehl et al.
Christian E Deuter et al.
Acute stress, potentially mediated by the stress-induced release of cortisol, affects decision-making processes. In the brain, cortisol activates two different types of receptors: the glucocorticoid receptor (GR) and the mineralocorticoid r...
Is Lumateperone Effective in Bipolar Depression? A Systematic Literature Review and Meta-Analysis on Placebo-Controlled Trials [0.03%]
露马曲普明治疗双相抑郁的疗效如何？基于安慰剂对照试验的系统综述和荟萃分析
Maurizio Pompili,Mariarosaria Cifrodelli,Maria Anna Trocchia et al.
Maurizio Pompili et al.
Bipolar depression is often difficult to treat and needs a specific therapeutic approach. This systematic review and meta-analysis aimed to evaluate the efficacy of lumateperone to be inclusive of more recently published studies with this a...
Time-Dependent Effects of Metformin and Olanzapine on the Metabolic System [0.03%]
二甲双胍和奥氮平对代谢系统的时间依赖性效应
Gizem Kurt,Seyda T Durhan,Mehmet Ak et al.
Gizem Kurt et al.
Second-generation antipsychotic drugs, such as olanzapine, have been associated with metabolic side effects including significant weight gain. Recent evidence suggests that this adverse effect may be attenuated by metformin.Male Wistar rats...
Influence of Glutamate Neurotransmission Genes on the Outcomes of Antipsychotic Treatments [0.03%]
谷氨酸神经递质基因对精神病治疗结果的影响
Marc Cendrós,Rosa Catalán,Mercè Torra et al.
Marc Cendrós et al.
Traditionally, the aetiology of schizophrenia has been attributed to dopaminergic neurotransmission, but more recent information points to the role of glutamate pathways. Glutamatergic involvement in schizophrenia might be extensible to dru...
Instruments Assessing Medication Literacy in Psychiatric Patients and the Caregivers: A Systematic Review [0.03%]
精神疾病患者及照料者用药依从性评估工具系统评价
Wan F H Wan Mohd Johari,Dayang F Abang Ma&#x;mon,Izyan A Wahab et al.
Wan F H Wan Mohd Johari et al.
This systematic review investigates the instruments measuring medication literacy (ML) in psychiatric patients and their caregivers. Despite the critical role of ML in ensuring adherence to medication regimens, especially in populations wit...
Ensemble Machine Learning Model for Real-Time Valproic Acid Prediction in Epilepsy Treatment [0.03%]
癫痫治疗中的实时丙戊酸预测的集成机器学习模型
Jiangchuan Xie,Pan Ma,Xinmei Pan et al.
Jiangchuan Xie et al.
To develop an optimal model to predict valproic acid (VPA) concentrations by machine learning, ensuring that the VPA plasma concentration is in the effective treatment range, and thus effectively control the patient's epilepsy.This single-c...
Cardiovascular Effects of Non-Selective Monoamine Oxidase Inhibitors and Intranasal Esketamine Combination in Depression - A Quasi-Experimental Design with Bayesian Analyses [0.03%]
非选择性单胺氧化酶抑制剂与鼻用艾斯氯胺酮联合治疗抑郁症的心血管效应：带有贝叶斯分析的准实验设计
Ludovic C Dormegny-Jeanjean,Suzie Lenoir,Ilia Humbert et al.
Ludovic C Dormegny-Jeanjean et al.
Ketamine and esketamine (ESK) offer new treatment options for resistant depression. Unlike traditional antidepressants, they can be used in combination with non-selective monoamine oxidase inhibitors (NS-MAOI) without the risk of serotonerg...
Scott Monteith,Tasha Glenn,John R Geddes et al.
Scott Monteith et al.
Both patients and physicians are routinely exposed to the corporate promotion of artificial intelligence (AI) for healthcare products. Hype for AI products may impact both patient behavior and attitudes about healthcare. Corporate AI hype m...
Regulatory Alignment of Psilocybin Clinical Trials in Major Depressive Disorder on ClinicalTrials.gov: A Cross-Sectional Analysis [0.03%]
美国主要抑郁症菌菇临床试验的监管一致性分析：横断面研究
Damian Swieczkowski,Aleksander Kwaśny,Michal Pruc et al.
Damian Swieczkowski et al.
Regulatory compliance is crucial in the clinical development of psychedelic substances, including psilocybin. This study aimed to examine the alignment of clinical trial protocols for psilocybin in the treatment of major depressive disorder...
Therapeutic Reference Range for Clozapine Plasma Levels in Parkinson's Disease or Dementia: A Systematic Review and Individual Participant Data Meta-analysis [0.03%]
系统的克洛齐普 plasma 水平治疗范围参考值在帕金森病或多发性痴呆中：系统回顾和个体患者数据meta分析
Nazar Kuzo,Marianna Piras,Ulrich C Lutz et al.
Nazar Kuzo et al.
Clozapine is a recommended treatment for psychotic symptoms in patients with Parkinson's disease (PD) and/or dementia. However, the therapeutic reference range for clozapine in these patients has not been established hitherto.The study was ...