Escitalopram and Clonazepam Affect Gasotransmitter-related Enzyme (nNOS, HO-2, CBS) Gene Expression in the Rat Brain [0.03%]
Artur Pałasz,Maria Sygidus,Antonello Pinna et al.
Artur Pałasz et al.
Gasotransmitters, nitric oxide, carbon monoxide, and hydrogen sulfide, play vital roles in neuroplasticity, neurogenesis, and neuromodulation, as well as in regulating oxidative stress, neuroinflammation, and neurotoxicity, all of which are...
Falk Gerrik Verhees,Isabella Catharina Wiest,Jakob Nikolas Kather et al.
Falk Gerrik Verhees et al.
Artificial intelligence in mental health has emerged as a potent tool to foster precision psychiatry, for example, by stratifying patient populations. A potential step forward would be mental health digital twins-the independent in-silico r...
Artificial Intelligence in Drug Discovery and Development: Raising Quality per Decision [0.03%]
药物发现与开发中的人工智能应用：提高决策质量
Shota Furukawa,Hiroyuki Uchida,Taishiro Kishimoto
Shota Furukawa
Drug research and development continuously encounters prolonged timelines, escalating costs, and high attrition rates. In this narrative review, we integrated recent advances in artificial intelligence across target identification, drug rep...
Serum Concentration-Dependent Inhibition of CYP2D6 by Bupropion and Doxepin: Implications for Venlafaxine and Risperidone Metabolism [0.03%]
舒必利和多塞平浓度依赖性抑制CYP2D6的作用：对文拉法辛和利培酮代谢的影响
Georgios N Zioris,Bodo Warrings,Jürgen Deckert et al.
Georgios N Zioris et al.
The increasing use of antidepressant combinations necessitates a deeper understanding of drug-drug interactions. This study investigated serum concentration-dependent CYP2D6 inhibition by bupropion (via hydroxybupropion) and doxepin at anti...
Intestinal Flora and Depression: Interaction Mechanisms and Therapeutic Prospects [0.03%]
肠道菌群与抑郁症：交互机制及治疗前景
Hao-Ran Zhang,Yu-Tao Yang
Hao-Ran Zhang
Depression is a mental disorder characterized by high incidence and relapse rates, and the search for effective treatments has been continuously pursued. To assess the effectiveness of existing studies, recent research advances are summariz...
Using Classification and Regression Tree Modeling to Investigate the Effects of Subanesthetic Ketamine Infusion on Remission of Suicidal Symptoms [0.03%]
采用分类和回归树模型研究次镇静剂量氯胺酮输注对自杀症状缓解的影响
Ping-Chung Wu,Wei-Chen Lin,Tung-Ping Su et al.
Ping-Chung Wu et al.
As accumulating evidence suggests the antisuicidal properties of ketamine, elucidating its underlying mechanisms and predictors of treatment response has become crucial. Whether a combination of clinical markers can enhance the prediction o...
Clinical Trial
Pharmacopsychiatry. 2026 Feb 26. DOI:10.1055/a-2807-8161 2026
Heart Rate-Corrected QT Interval Dynamics Following Antidepressant Switching from Escitalopram to High-Dose Venlafaxine: Cardiac Safety Insights from the Early Medication Change Cohort [0.03%]
从艾司西酞普兰换用至高剂量文拉法辛后的心率校正的QT间期动力学变化：来自早期药物替换队列的心脏安全性启示
Jan Engelmann,Andreas Solheid,Stefanie Wagner et al.
Jan Engelmann et al.
Electrocardiographic changes indicating a significantly increased risk of adverse cardiac effects, such as heart-rate corrected QT interval prolongation, are rare during antidepressant treatment; however, systematic analyses are lacking. Th...
Clinical Trial
Pharmacopsychiatry. 2026 Feb 26. DOI:10.1055/a-2793-9711 2026
Babet N Wezenberg,Jara Bouws,Marieke van der Pluijm et al.
Babet N Wezenberg et al.
Antipsychotic medications are essential in treating psychotic disorders; yet, large-scale studies examining individual patient preferences are lacking. The current study explores variations in patient perspectives on antipsychotic treatment...
Correction: Cannabidiol and its Potential Evidence-Based Psychiatric Benefits - A Critical Review [0.03%]
纠正：大麻二酚及其潜在的基于证据的精神病益处-批判性评论
Inga Dammann,Cathrin Rohleder,F Markus Leweke
Inga Dammann
Published Erratum
Pharmacopsychiatry. 2024 May;57(3):e2. DOI:10.1055/a-2775-0902 2024
Social Robots in Psychiatry for Patients Suffering from Major Depression-A Pilot Study [0.03%]
用于重度抑郁患者的精神病学社交机器人——一项初步研究
Paraskevi Mavrogiorgou,Robert Heymel,Luisa Richter et al.
Paraskevi Mavrogiorgou et al.
Since the coronavirus pandemic in 2019, interest in implementing and establishing digital media, for example, in the form of humanoid social robots, in everyday psychiatric and psychotherapeutic practice has grown enormously.Thirty patients...