Increased Glycolytic Activity Is Part of Impeded M1(LPS) Macrophage Polarization in the Presence of Urolithin A [0.03%]
尿石素A存在时M1（LPS）巨噬细胞极化受阻的原因之一是其糖酵解活性下降
Sheyda Bahiraii,Barbara Braunböck-Müller,Elke H Heiss
Sheyda Bahiraii
Urolithin A is a gut metabolite of ellagitannins and reported to confer health benefits, e.g., by increased clearance of damaged mitochondria by macroautophagy or curbed inflammation. One targeted cell type are macrophages, which are plasti...
Variability of Chalcone Synthase in Chamomile Accessions (Matricaria chamomilla) [0.03%]
马郁兰（Matricariachamomilla）中查尔康素合成酶的变异性
Melanie Novak,Dijana Jovanovic,Johannes Novak
Melanie Novak
Chamomile (Matricaria chamomilla) is an important medicinal plant whose beneficial activities partly rely on certain flavonoids. The first dedicated step in flavonoid biosynthesis is chalcone synthase (CHS, EC 2.3.1.74). The genomic DNA of ...
Novel Approaches for the Analysis and Isolation of Benzylisoquinoline Alkaloids in Chelidonium majus [0.03%]
毛果芸香中生物碱苯基异喹啉的新分析和分离方法
Michael Zwerger,Lynda Boeck,Julia Manzl et al.
Michael Zwerger et al.
Benzylisoquinoline alkaloids are the major bioactive components in Chelidonium majus, a plant that has a long usage history for the treatment of gastrointestinal ailments in European and Asian phytomedicine. This study reports on the develo...
A Metabolomic Approach to Investigate the Effect of Phytonutrients on Proteostasis and Metabolic Pathways in Drosophila melanogaster [0.03%]
基于果蝇的植物营养素对蛋白质稳态及代谢通路的影响研究的代谢组学方法探讨
Eleni V Mikropoulou,Zoi Evangelakou,Ioannis P Trougakos et al.
Eleni V Mikropoulou et al.
The use of Drosophila melanogaster as a biological platform to study the effect of diet and food bioactives on the metabolome remains a highly unexplored subject. Aiming to establish alternative solutions for the investigation of nutritiona...
VOLKSMED Database: A Source for Forgotten Wound Healing Plants in Austrian Folk Medicine [0.03%]
VOLKSMED数据库：奥地利民间医学中被遗忘的伤口愈合植物资料库
Elisabeth Eichenauer,Johannes Saukel,Sabine Glasl
Elisabeth Eichenauer
The global increase in the incidence of wounds is concerning and fuels the search for new treatment options. The use of traditional medicinal plants in wound healing represents an appreciated available therapeutic possibility. This work int...
Discovery and Characterization of Panaxatriol as a Novel Thrombin Inhibitor from Panax notoginseng Using a Combination of Computational and Experimental Approaches [0.03%]
基于计算与实验相结合的方法发现并确认了三七茋醇为抗凝血酶新成分
Xing Wang,Yuqing Ma,Chunfang Zuo et al.
Xing Wang et al.
Thrombin is a crucial enzyme in the coagulation cascade, and inhibitors of thrombin have been extensively studied as potential antithrombotic agents. The objective of this study was to identify natural inhibitors of thrombin from Panax noto...
(R)-(-)-Xanthorrhizol Inhibits the Migration and Invasion of Triple-Negative Breast Cancer Cells by Suppressing Matrix Metalloproteinases via the NF-κB Signaling Pathway [0.03%]
(R)-(-)-黄姜酚通过抑制NF-κB信号途径控制的基质金属蛋白酶来抑制三阴性乳腺癌细胞的迁移和侵袭作用
Mohammad Al-Amin,Siti Sarah Fazalul Rahiman,Melati Khairuddean et al.
Mohammad Al-Amin et al.
(R)-(-)-xanthorrhizol is a bioactive sesquiterpenoid and major chemical constituent of Curcuma zanthorrhiza rhizomes. It was reported to have many pharmacological activities including nephroprotective, hepatoprotective, antimicrobial, anti-...
Paclitaxel - a Product of Fungal Secondary Metabolism or an Artefact? [0.03%]
博来霉素——一种真菌次生代谢产物还是一种实验产物？
Klaus Ferdinand Gärditz,Hjördis Czesnick
Klaus Ferdinand Gärditz
Taxol (common name: paclitaxel) is an extremely important component of drugs for the treatment of various cancers. Thirty years after the discovery of its effectiveness, a metabolic precursor of Taxol (10-deacetylbaccatin III) is still prim...
Estrogenic Activity of Derris scandens Stem Extract and its Major Compounds Using MCF-7 Cell Proliferation Assay and Estrogen-Related Gene Expression [0.03%]
基于MCF-7细胞增殖测定和雌激素相关基因表达的鸡眼藤茎提取物及其主要化合物的雌激素活性研究
Worapol Sae-Foo,Gorawit Yusakul,Natsajee Nualkaew et al.
Worapol Sae-Foo et al.
Derris scandens, which contains isoflavones and prenylated derivatives, has analgesic and anti-inflammatory properties and is an ingredient in traditional Thai medicine for perimenopause and menopause. However, the estrogenic activity of D....