Alkaline phosphatase determines polyphosphate-induced mineralization in a cell-type independent manner [0.03%]
无细胞类型的碱性磷酸酶决定多聚磷酸诱导的矿化作用
Yoshikazu Mikami,Hiromasa Tsuda,Yuko Akiyama et al.
Yoshikazu Mikami et al.
Polyphosphate [Poly(P)] has positive effects on osteoblast mineralization; however, the underlying mechanism remains unclear. In addition, it is unknown whether Poly(P) promotes mineralization in soft tissues. We investigated this by using ...
Alendronate does not prevent long bone fragility in an inactive rat model [0.03%]
阿仑膦酸不能预防活动减少大鼠长骨脆性增加
K Naruse,K Uchida,M Suto et al.
K Naruse et al.
The lack of estrogen and inactivity are both important in the pathogenesis of osteoporosis in elderly women, and there have been no appropriate rodent studies to examine the effects of common bisphosphonates on these two components separate...
Higher response with bone mineral density increase with monthly injectable ibandronate 1 mg compared with oral risedronate in the MOVER study [0.03%]
一项比较每月注射依班膦酸钠与口服利塞磷酸盐对骨密度影响的临床研究（MOVER研究）
Tetsuo Nakano,Masao Yamamoto,Junko Hashimoto et al.
Tetsuo Nakano et al.
We examined response to bone mineral density (BMD) gains in the MOVER study following treatment with intravenous (IV) ibandronate 1 mg/month, and investigated the characteristics of a non-responder group. At 1 year, responder rates for pati...
Randomized Controlled Trial
Journal of bone and mineral metabolism. 2016 Nov;34(6):678-684. DOI:10.1007/s00774-015-0717-8 2016
Genetic risk score based on the lifetime prevalence of femoral fracture in 924 consecutive autopsies of Japanese males [0.03%]
基于924例日本男性尸体解剖的股骨骨折终生患病率的遗传风险评分
Heying Zhou,Seijiro Mori,Tatsuro Ishizaki et al.
Heying Zhou et al.
A genetic risk score (GRS) was developed for predicting fracture risk based on lifetime prevalence of femoral fractures in 924 consecutive autopsies of Japanese males. A total of 922 non-synonymous single nucleotide polymorphisms (SNPs) loc...
Z-score discordance and contributing factors in healthy premenopausal women with low bone mineral density: the Korean National Health and Nutrition Examination Survey 2008-9 [0.03%]
韩国2008至2009年国民健康与营养调查中的低骨密度健康育龄妇女的Z评分差异及其影响因素
Kyeong Hye Park,Jung Soo Lim,Kyoung Min Kim et al.
Kyeong Hye Park et al.
The premenopausal period is important for bone health and prevention of future fractures, but measuring bone mineral density (BMD) at only one site may not be sufficient to determine therapeutic strategies for low BMD in premenopausal women...
The role of serum osteoprotegerin and receptor-activator of nuclear factor-κB ligand in metabolic bone disease of women after obesity surgery [0.03%]
肥胖手术后女性代谢性骨病患者血清osteoprotegerin和核因子κB受体活化剂配基的作用
José A Balsa,Christian Lafuente,Jesús M Gómez-Martín et al.
José A Balsa et al.
Metabolic bone disease may appear as a complication of obesity surgery. Because an imbalance in the osteoprotegerin and receptor-activator of nuclear factor-κB ligand system may underlie osteoporosis, we aimed to study this system in human...
Identification and functional analysis of a novel CaSR mutation in a family with familial hypocalciuric hypercalcemia [0.03%]
家族性低钙尿高钙血症家系中新型CaSR突变的鉴定及功能分析
Eun Sook Kim,Su Yeon Kim,Ji Young Lee et al.
Eun Sook Kim et al.
The calcium-sensing receptor (CaSR) is a G-protein-coupled receptor that plays an essential role in maintaining calcium homeostasis. In the present study, we analyzed the CaSR gene in a Korean family with familial hypocalciuric hypercalcemi...
Identification of a progenitor cell population destined to form fracture fibrocartilage callus in Dickkopf-related protein 3-green fluorescent protein reporter mice [0.03%]
Dickkopf相关蛋白3绿色荧光蛋白报告小鼠骨折纤维软骨痂形成细胞的鉴定
Yu Mori,Douglas Adams,Yusuke Hagiwara et al.
Yu Mori et al.
Fracture healing is a complex biological process involving the proliferation of mesenchymal progenitor cells, and chondrogenic, osteogenic, and angiogenic differentiation. The mechanisms underlying the proliferation and differentiation of m...
Bone mineral density of postmenopausal women with rheumatoid arthritis depends on disease duration regardless of treatment [0.03%]
绝经后类风湿关节炎妇女的骨密度与病程有关，而非治疗因素所致
Yu Mori,Yoshiyuki Kuwahara,Shinpei Chiba et al.
Yu Mori et al.
The aim of this study was to determine the associations of disease activity and disease duration with the bone mineral density (BMD) in rheumatoid arthritis (RA) patients. We also evaluated the associations of biological drugs with bone los...
Analysis of bone metabolism during early stage and clinical benefits of early intervention with alendronate in patients with systemic rheumatic diseases treated with high-dose glucocorticoid: Early DIagnosis and Treatment of OsteopoRosis in Japan (EDITOR-J) study [0.03%]
日本早期内科风湿病高剂量糖皮质激素治疗患者的早期骨代谢分析及阿仑膦酸早期干预的临床效益：EDITOR-J研究
Yoshiya Tanaka,Hiroko Mori,Takatoshi Aoki et al.
Yoshiya Tanaka et al.
We conducted a prospective multicenter study to assess early changes in the dynamics of bone metabolism in patients with systemic connective tissue diseases following commencement of high-dose glucocorticoid therapy and the benefits of earl...
Randomized Controlled Trial
Journal of bone and mineral metabolism. 2016 Nov;34(6):646-654. DOI:10.1007/s00774-015-0709-8 2016