Less strict intervention thresholds for the FRAX and TBS-adjusted FRAX predict clinical fractures in osteopenic postmenopausal women with no prior fractures [0.03%]
对于既往无骨折的绝经后骨量减少女性，较低的FRAX和TBS校正FRAX干预阈值可预测临床骨折风险
Martin Kužma,Didier Hans,Tomáš Koller et al.
Martin Kužma et al.
Little is known about the clinical relevance of treating post-menopausal women with no prior history of fragility fracture and bone mineral densities (BMD) within the osteopenic range. In recent years, in addition to BMD and FRAX fracture p...
A decrease in the number and incidence of osteoporotic hip fractures among elderly individuals in Niigata, Japan, from 2010 to 2015 [0.03%]
日本新潟地区老年人骨质疏松性髋部骨折数量和发病率从2010年到2015年的下降趋势
Norio Imai,Naoto Endo,Yugo Shobugawa et al.
Norio Imai et al.
We investigated the incidence of hip fracture in patients aged ≥50 years in 2015 in Niigata Prefecture, Japan. We also determined the long-term trend in hip fracture incidence from 1985 to 2015. In 2015, 3214 hip fractures occurred in Niig...
Genetic interaction of purinergic P2X7 receptor and ER-α polymorphisms in susceptibility to osteoporosis in Chinese postmenopausal women [0.03%]
中国绝经后妇女骨质疏松症易感性的嘌呤P2X7受体和雌激素受体-α多态性遗传互动作用研究
Hui Wang,Chengxin Gong,Xingzi Liu et al.
Hui Wang et al.
Osteoporosis (OP) is an increasing public health problem worldwide. Genetic factors are considered to be major contributors to the pathogenesis of OP. The aim of this study was to investigate the association of the purinergic P2X7 receptor ...
Effects of interventions with a physical activity component on bone health in obese children and adolescents: a systematic review and meta-analysis [0.03%]
肥胖儿童和青少年骨健康的身体活动干预效应系统评价和meta分析
Elodie Chaplais,Geraldine Naughton,David Greene et al.
Elodie Chaplais et al.
Given the rise in pediatric obesity, clarifications on the relationship between obesity and bone health and on the impact of structured intervention on this relationship are needed. This systematic review and meta-analysis investigated the ...
THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis [0.03%]
THRAP3通过与SOX9相互作用抑制软骨发生中的转录活性
Takashi Sono,Haruhiko Akiyama,Shigenori Miura et al.
Takashi Sono et al.
Sex-determining region Y (Sry)-box (Sox)9 is required for chondrogenesis as a transcriptional activator of genes related to chondrocyte proliferation, differentiation, and cartilage-specific extracellular matrix. Although there have been st...
Assessment of the effects of switching oral bisphosphonates to denosumab or daily teriparatide in patients with rheumatoid arthritis [0.03%]
评估从口服双膦酸盐切换至地诺单抗或特立帕肽对类风湿关节炎患者疗效的影响
Kosuke Ebina,Makoto Hirao,Jun Hashimoto et al.
Kosuke Ebina et al.
The aim of this observational, non-randomized study was to clarify the unknown effects of switching oral bisphosphonates (BPs) to denosumab (DMAb) or daily teriparatide (TPTD) in patients with rheumatoid arthritis (RA). The characteristics ...
Observational Study
Journal of bone and mineral metabolism. 2018 Jul;36(4):478-487. DOI:10.1007/s00774-017-0861-4 2018
Extracellular vesicle-mediated bone metabolism in the bone microenvironment [0.03%]
骨微环境中的细胞外囊泡介导的骨代谢
Qi Li,Qiu-Ping Huang,Yi-Lin Wang et al.
Qi Li et al.
Extracellular vesicles (EVs) are phospholipid membrane-enclosed entities containing specific proteins, RNA, miRNA, and lncRNA. EVs are released by various cells and play a vital role in cell communication by transferring their contents from...
Allogeneic yet major histocompatibility complex-matched bone marrow transplantation in mice results in an impairment of osteoblasts and a significantly reduced trabecular bone [0.03%]
同种异体但主要组织相容性复合物匹配的骨髓移植导致小鼠成骨细胞功能障碍和显著减少的小梁骨量
Anja Osterberg,Robby Engelmann,Brigitte Müller-Hilke
Anja Osterberg
Secondary osteopenia following allogeneic bone marrow or stem cell transplantation (BMT or HSCT) is a significant source of morbidity in patients. It is believed to be caused by a number of factors related to the myeloablative conditioning ...
Inhaled glucocorticoids are associated with vertebral fractures in COPD patients [0.03%]
吸入性糖皮质激素与慢性阻塞性肺疾病患者的椎骨骨折有关
Pedro Assed Gonçalves,Rafael Dos Santos Neves,Leonardo Vieira Neto et al.
Pedro Assed Gonçalves et al.
Chronic obstructive pulmonary disease (COPD) is an independent risk factor for osteoporosis. Oral glucocorticoids are deleterious to bone; however, the impact of inhaled glucocorticoids (ICS) remains unclear. Our objective was to determine ...
Mohammed T Alsamri,Suleiman Al-Hammadi,Barira Islam et al.
Mohammed T Alsamri et al.
Phosphorescence O2 analyzer was used to measure calvarial bone cellular respiration (cellular mitochondrial O2 consumption) in Taylor Outbred mice in the presence and absence of zoledronic acid. This potent bisphosphonate inhibits osteoclas...