NEFL is associated with inhibition of odontoblastic process in odontohypophosphatasia [0.03%]
NEFL与odontohypophosphatasia中抑制牙本质细胞过程相关
Akira Nozoe,Yasuhisa Ohata,Makoto Fujiwara et al.
Akira Nozoe et al.
Introduction: Hypophosphatasia (HPP) is a rare bone disease caused by pathological variants of ALPL. While hypomineralization of dentin and odontoblast (OD) differentiation defects are known to occur in HPP, the underlyin...
Treatment with romosozumab in patients with osteoporosis on maintenance hemodialysis [0.03%]
接受维持性血液透析的骨质疏松症患者的Romosozumab治疗
Michael Pazianas,Paul D Miller
Michael Pazianas
Inverse association between diet quality and the risk of osteoporotic fractures: a cross-sectional analysis [0.03%]
饮食质量与骨质疏松性骨折风险之间的逆向关联：横断面分析
Xi Liu,Bin Xu
Xi Liu
Introduction: This study aimed to systematically evaluate the association between the Healthy Eating Index (HEI-2020), the Alternative Healthy Eating Index (AHEI), and the risk of osteoporotic fractures based on the Natio...
Editorial comment [0.03%]
编者按
Toshio Matsumoto,Toshiyuki Yoneda
Toshio Matsumoto
Shane Dong,Hiroyuki Hirakawa
Shane Dong
Background: Hematopoietic stem cells (HSCs) are the lifelong source of hematopoietic cells, maintained within the specialized microenvironment of the bone marrow. A central question remains regarding the mechanisms that r...
Keita Kondo,Yuki Matsushita
Keita Kondo
Introduction: Skeletal stem cells (SSCs) and their lineage derivatives play essential roles in bone development, maintenance, and regeneration. In addition to their physiological functions, SSCs have been implicated in pr...
Multifunctional LepR⁺ skeletal stem/progenitor cells for bone and marrow homeostasis [0.03%]
多功能LepR+骨干细胞/前体细胞维持骨骼和骨髓稳态
Karishma Madhusudan Desai,Toshihide Mizoguchi
Karishma Madhusudan Desai
Background: Bone is a multifunctional organ that provides structural support and hosts the bone marrow, a key site for hematopoiesis and systemic homeostasis. These dual features have long attracted the attention of both ...
Inflammaging in periodontal, periapical, and malignancy-associated disease: drivers of alveolar bone loss and repair [0.03%]
牙周病、根尖周组织病和肿瘤相关疾病中的炎症衰老：齿槽骨丧失与修复的驱动因素
Meircurius Dwi Condro Surboyo,Kridtapat Sirisereephap,Tomoki Maekawa
Meircurius Dwi Condro Surboyo
Background: Aging significantly impacts bone metabolism through altered osteoblast/osteoclast dynamics, reduced stem cell regeneration, and chronic inflammaging. This narrative review explores how these age-related change...
Osteoporosis risk with sodium-glucose cotransporter 2 inhibitors versus thiazolidinediones in older women with diabetes [0.03%]
糖尿病老年女性使用钠-葡萄糖共转运蛋白2抑制剂和噻唑烷二酮类药物的骨质疏松症风险比较研究
Hyeon Jeong Lee,Pusoon Chun
Hyeon Jeong Lee
Introduction: This study aimed to compare the risk of osteoporosis between sodium-glucose cotransporter 2 inhibitors (SGLT2is) and thiazolidinediones (TZDs) in older women with type 2 diabetes (T2D). ...
Evocalcet improved the PTH-calcium setpoint and suppressed parathyroid proliferation in mice model of primary hyperparathyroidism [0.03%]
艾维卡塞特改善了原发性甲状旁腺功能亢进小鼠模型中的PTH-钙稳定点并抑制了甲状旁腺增殖
Yasuo Imanishi,Tomoe Hirakawa,Waka Haruyama et al.
Yasuo Imanishi et al.
Background: Evocalcet is an allosteric modulator of the calcium-sensing receptor (CaSR) that effectively suppresses parathyroid hormone (PTH) secretion in both primary and secondary hyperparathyroidism. However, its effec...