Editorial comment [0.03%]
编者按
Toshio Matsumoto,Toshiyuki Yoneda
Toshio Matsumoto
Shane Dong,Hiroyuki Hirakawa
Shane Dong
Background: Hematopoietic stem cells (HSCs) are the lifelong source of hematopoietic cells, maintained within the specialized microenvironment of the bone marrow. A central question remains regarding the mechanisms that r...
Keita Kondo,Yuki Matsushita
Keita Kondo
Introduction: Skeletal stem cells (SSCs) and their lineage derivatives play essential roles in bone development, maintenance, and regeneration. In addition to their physiological functions, SSCs have been implicated in pr...
Multifunctional LepR⁺ skeletal stem/progenitor cells for bone and marrow homeostasis [0.03%]
多功能LepR+骨干细胞/前体细胞维持骨骼和骨髓稳态
Karishma Madhusudan Desai,Toshihide Mizoguchi
Karishma Madhusudan Desai
Background: Bone is a multifunctional organ that provides structural support and hosts the bone marrow, a key site for hematopoiesis and systemic homeostasis. These dual features have long attracted the attention of both ...
Inflammaging in periodontal, periapical, and malignancy-associated disease: drivers of alveolar bone loss and repair [0.03%]
牙周病、根尖周组织病和肿瘤相关疾病中的炎症衰老：齿槽骨丧失与修复的驱动因素
Meircurius Dwi Condro Surboyo,Kridtapat Sirisereephap,Tomoki Maekawa
Meircurius Dwi Condro Surboyo
Background: Aging significantly impacts bone metabolism through altered osteoblast/osteoclast dynamics, reduced stem cell regeneration, and chronic inflammaging. This narrative review explores how these age-related change...
Osteoporosis risk with sodium-glucose cotransporter 2 inhibitors versus thiazolidinediones in older women with diabetes [0.03%]
糖尿病老年女性使用钠-葡萄糖共转运蛋白2抑制剂和噻唑烷二酮类药物的骨质疏松症风险比较研究
Hyeon Jeong Lee,Pusoon Chun
Hyeon Jeong Lee
Introduction: This study aimed to compare the risk of osteoporosis between sodium-glucose cotransporter 2 inhibitors (SGLT2is) and thiazolidinediones (TZDs) in older women with type 2 diabetes (T2D). ...
Evocalcet improved the PTH-calcium setpoint and suppressed parathyroid proliferation in mice model of primary hyperparathyroidism [0.03%]
艾维卡塞特改善了原发性甲状旁腺功能亢进小鼠模型中的PTH-钙稳定点并抑制了甲状旁腺增殖
Yasuo Imanishi,Tomoe Hirakawa,Waka Haruyama et al.
Yasuo Imanishi et al.
Background: Evocalcet is an allosteric modulator of the calcium-sensing receptor (CaSR) that effectively suppresses parathyroid hormone (PTH) secretion in both primary and secondary hyperparathyroidism. However, its effec...
Causal association between gut microbiota and osteonecrosis in European populations: a two-sample Mendelian randomization analysis [0.03%]
欧洲人群中肠道菌群与骨坏死的因果关系：两样本孟德尔随机化分析
Haiqing Li,Zhen Yang,Mingfeng Li et al.
Haiqing Li et al.
Introduction: Recent studies have linked gut microbiota composition to osteonecrosis, but the causal relationship remains unclear. Clarifying this relationship is clinically important because osteonecrosis currently lacks...
Endothelial diversity in bone vasculature coordinates osteogenesis and hematopoiesis [0.03%]
骨血管内皮细胞多样性协调成骨和造血功能
Takahito Iga
Takahito Iga
Bone is a highly vascularized organ, and the vasculature in bone not only delivers oxygen and nutrients but also helps determine when and where bone forms, how the marrow is organized, and how hematopoietic stem cells (HSCs) are maintained....
Alterations in bone-related hormones and genes expression in femoral bone of polycystic ovary syndrome rats [0.03%]
多囊卵巢综合征大鼠股骨骨相关激素及基因表达变化研究
Mahsa Noroozzadeh,Mostafa Changaei,Mahbanoo Farhadi-Azar et al.
Mahsa Noroozzadeh et al.
Introduction: Polycystic ovary syndrome (PCOS) has been associated with conflicting effects on bone mass, underscoring the need for deeper investigation into its impact on skeletal health. This study aimed to assess the e...