Meclozine and growth hormone ameliorate bone length and quality in experimental models of achondroplasia [0.03%]
美洛辛和生长激素改善实验性软骨发育不全模型的骨骼长度和质量
Kenta Sawamura,Masaki Matsushita,Ryusaku Esaki et al.
Kenta Sawamura et al.
Introduction: Achondroplasia (ACH) is a common skeletal dysplasia associated with short-limbed short stature caused by gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. Meclozine was foun...
Nationwide database study of postoperative sequelae and in-hospital mortality in super-elderly hip fracture patients [0.03%]
全国范围的数据库研究：超高龄髋部骨折患者术后并发症及院内死亡率研究
Yu Mori,Kunio Tarasawa,Hidetatsu Tanaka et al.
Yu Mori et al.
Introduction: The risk of postoperative sequelae and in-hospital mortality in Japanese patients aged 90 years and older with hip fractures is unexplored. This study aims to use a comprehensive medical claims database in J...
Influence of disease activity and gonadal status on bone mineral density and turnover in acromegaly [0.03%]
肢端肥大症患者的疾病活动度和性腺功能对骨密度及骨转换的影响
Fabiana Freire Silva,Maria de Lourdes Lima,Clarissa Carvalho Pedreira et al.
Fabiana Freire Silva et al.
Introduction: The purpose of this study was to evaluate the impact of disease activity and gonadal status on bone mineral density (BMD) and turnover markers (BTMs) in individuals with acromegaly. ...
Aromatase inhibitors, bone microstructure, and estimated bone strength in postmenopausal women with breast cancer: a 5-year prospective study [0.03%]
aromatase抑制剂、骨微结构与绝经后乳腺癌女性的估计骨强度：一项为期五年的前瞻性研究
Sayaka Kuba,Ko Chiba,Kounosuke Watanabe et al.
Sayaka Kuba et al.
Introduction: Aromatase inhibitors (AIs) are the standard treatment for early breast cancer (EBC) and are typical causative agents of cancer treatment-induced bone loss. However, the effects of long-term treatment with th...
Association between the Sp1-binding-site polymorphism in the collagen type I alpha 1 (COLIA1) gene and bone phenotypes: the Dubbo Osteoporosis Epidemiology Study [0.03%]
胶原I型α1（COLIA1）基因Sp1结合位点多态性与骨表型的关系：Dubbo骨质疏松流行病学研究
Ngoc Huynh,Krisel De Dios,Thach S Tran et al.
Ngoc Huynh et al.
Introduction: Polymorphisms within the collagen 1 alpha 1 gene (COLIA1) have been shown to be associated with bone mineral density (BMD). This study aimed to test the hypothesis that COLIA1 polymorphisms are associated wi...
Disulfiram ameliorates bone loss in ovariectomized mice by suppressing osteoclastogenesis [0.03%]
戒酒硫通过抑制破骨细胞生成改善卵巢切除小鼠的骨丢失症状
Tatsuyuki Fukui,Asuka Terashima,Yasunori Omata et al.
Tatsuyuki Fukui et al.
Introduction: Disulfiram (DSF), known as an anti-alcoholism drug, has been reported to suppress osteoclast differentiation in vitro; however, it remains uncertain whether DSF is effective in preventing osteoclastogenesis ...
Toshihisa Komori
Toshihisa Komori
Hedgehog and canonical Wnt signaling pathways and the transcription factors Runx2 and Sp7 are essential for osteoblast differentiation. Ihh is necessary for the commitment of perichondrial mesenchymal cells to Runx2+ osteoprogenitors and fo...
Accelerated bone loss in late reproductive-aged and perimenopausal women with vitamin D insufficiency [0.03%]
维生素D不足会导致晚育龄期和围绝经期女性骨量快速流失
Min-Jeong Kim,Sunmie Kim,Jin Ju Kim et al.
Min-Jeong Kim et al.
Introduction: The association between serum vitamin D levels and bone mineral density (BMD) varies by race and gender. This study aimed to evaluate this relationship between serum vitamin D levels and BMD, and changes of ...
Efficacy of a single 5 mg zoledronic acid infusion in preventing bone loss and fracture in postmenopausal women with breast cancer [0.03%]
5毫克唑来磷酸单次输注预防绝经后乳腺癌妇女骨丢失和骨折的疗效研究
Han-Sang Baek,Kabsoo Shin,Jinyoung Kim et al.
Han-Sang Baek et al.
Introduction: Chemotherapy-induced bone loss (CTIBL) is common among breast cancer patients, requiring comprehensive assessment and intervention. Zoledronic acid, a strong inhibitor of bone resorption, is effective in CTI...
Observational Study
Journal of bone and mineral metabolism. 2024 Nov;42(6):720-727. DOI:10.1007/s00774-024-01552-0 2024
Yilun Tang,Yan Xu,Jinhui Song et al.
Yilun Tang et al.
Objective: This study aimed to estimate the relation between cigarette smoking and hip fracture in men compared with women using a meta-analytic approach. ...