Vitamin D status of Icelandic children and its influence on bone accrual [0.03%]
冰岛儿童的维生素D状况及其对骨密度积累的影响
Haukur Heidar Hauksson,Hannes Hrafnkelsson,Kristjan Thor Magnusson et al.
Haukur Heidar Hauksson et al.
The importance of vitamin D for children's bone health has been well established, but the effects of less severe deficiency are not fully known. The main objective of this study was to assess the vitamin D status of Icelandic children at th...
Vitamin D receptor polymorphisms and growth until adulthood after very premature birth [0.03%]
维生素D受体多态性与极早早产儿的成人前生长关系研究
Martijn J J Finken,Marlies Schrevel,Jeanine J Houwing-Duistermaat et al.
Martijn J J Finken et al.
The accretion of bone mass is often impaired in preterm infants, which may contribute to postnatal growth failure. We tested the effects of the vitamin D receptor single-nucleotide polymorphisms (SNPs) c1521g, Fok1, Bsm1, and Taq1 on linear...
Qingyun Wu,Xueting Xiong,Xinle Zhang et al.
Qingyun Wu et al.
Numerous studies have demonstrated that rheumatoid arthritis (RA) is often associated with bone loss; however, few experiments have focused on cancellous and cortical bone changes in rats during the process of arthritis. We have investigate...
Esomeprazole use is independently associated with significant reduction of BMD: 1-year prospective comparative safety study of four proton pump inhibitors [0.03%]
埃索美拉唑的使用与骨密度具有独立性的显著相关性：四种质子泵抑制剂一年期前瞻性比较安全性研究
Elton Bahtiri,Hilmi Islami,Rexhep Hoxha et al.
Elton Bahtiri et al.
Because of the efficacy of proton pump inhibitors (PPIs), their the use is increasing dramatically. The risk of adverse effects of short-term PPI therapy is low, but there are important safety concerns for potential adverse effects of prolo...
Observational Study
Journal of bone and mineral metabolism. 2016 Sep;34(5):571-9. DOI:10.1007/s00774-015-0699-6 2016
Eldecalcitol improves muscle strength and dynamic balance in postmenopausal women with osteoporosis: an open-label randomized controlled study [0.03%]
艾地罗可改善绝经后骨质疏松妇女的肌肉力量和动态平衡：一项开放标签随机对照研究
Kimio Saito,Naohisa Miyakoshi,Toshiki Matsunaga et al.
Kimio Saito et al.
The antifracture efficacy of vitamin D in osteoporosis is due to its direct action on bones and indirect extraskeletal effects to prevent falls. Eldecalcitol is an analog of active vitamin D3 that improves bone mineral density and reduces t...
Randomized Controlled Trial
Journal of bone and mineral metabolism. 2016 Sep;34(5):547-54. DOI:10.1007/s00774-015-0695-x 2016
Role of osteoclasts in heterotopic ossification enhanced by fibrodysplasia ossificans progressiva-related activin-like kinase 2 mutation in mice [0.03%]
小鼠纤维发育不良进展性骨病相关活化素样激酶2突变增强异位骨化中破骨细胞的作用
Naoyuki Kawao,Masato Yano,Yukinori Tamura et al.
Naoyuki Kawao et al.
Fibrodysplasia ossificans progressiva (FOP) is a disorder of skeletal malformations and progressive heterotopic ossification. The constitutively activating mutation (R206H) of the bone morphogenetic protein type 1 receptor, activin-like kin...
Bone mineral density and changes in bone metabolism in patients with obstructive sleep apnea syndrome [0.03%]
阻塞性睡眠呼吸暂停综合征患者的骨密度及骨代谢变化
Rabia Terzi,Zahide Yılmaz
Rabia Terzi
The aim of this study was to evaluate the differences between patients with obstructive sleep apnea syndrome (OSAS) and phenotypically similar subjects without OSAS in terms of bone mineral density (BMD) and bone turnover markers. The study...
Tensile force on human macrophage cells promotes osteoclastogenesis through receptor activator of nuclear factor κB ligand induction [0.03%]
张力通过诱导核因子κB配体而促进破骨细胞的生成
Chia-Tze Kao,Tsui-Hsien Huang,Hsin-Yuan Fang et al.
Chia-Tze Kao et al.
Little is known about the effects of tensile forces on osteoclastogenesis by human monocytes in the absence of mechanosensitive cells, including osteoblasts and fibroblasts. In this study we consider the effects of tensile force on osteocla...
Effects of strontium ranelate on bone mass and bone turnover in women with thalassemia major-related osteoporosis [0.03%]
雷奈酸锶对输血依赖性β-地中海贫血相关性骨质疏松患者骨密度及骨转换标志物的影响
Nunziata Morabito,Antonino Catalano,Agostino Gaudio et al.
Nunziata Morabito et al.
Subjects affected by thalassemia major (TM) often have reduced bone mass and increased fracture risk. Strontium ranelate (SrR) is an effective treatment for postmenopausal and male osteoporosis. To date, no data exist on the use of SrR in t...
Randomized Controlled Trial
Journal of bone and mineral metabolism. 2016 Sep;34(5):540-6. DOI:10.1007/s00774-015-0689-8 2016
Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors [0.03%]
甲氨蝶呤通过减少破骨前体细胞中RANKL诱导的钙离子内流来抑制成骨细胞生成
Hiroya Kanagawa,Ritsuko Masuyama,Mayu Morita et al.
Hiroya Kanagawa et al.
The increasing number of osteoporosis patients is a pressing issue worldwide. Osteoporosis frequently causes fragility fractures, limiting activities of daily life and increasing mortality. Many osteoporosis patients take numerous medicines...