When to Hold and When to Fold: The Clinical Approach to Locoregional Recurrence After Curative Treatment of Solid Cancers [0.03%]
何时继续治疗，何时放弃？固体癌根治性治疗后局部区域复发的临床处理原则
N Joseph,P J Hoskin
N Joseph
Although retreatment of locoregional recurrence offers a critical window of opportunity for curative intervention, it poses a significant clinical challenge due to its complex nature and the scarcity of high-level evidence to guide optimal ...
Association Between Dose Reduction of Cyclin-dependent Kinase 4/6 Inhibitors and Survival in Advanced Breast Cancer: A Systematic Review and Meta-analysis [0.03%]
cyclin依赖性激酶4/6抑制剂减药与晚期乳腺癌患者生存期之间关联的系统评价和meta分析
F Petrelli,A Ghidini,L Dottorini
F Petrelli
Aims: The integration of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors into the treatment regimen for advanced breast cancer (BC), specifically oestrogen receptor-positive (ER+) subtypes, marks a significant stride in o...
Clinical Impact of Next-Generation Sequencing-Guided Targeted Therapies in Advanced Cancer: A Systematic Review and Meta-Analysis [0.03%]
基于下一代测序的靶向治疗在晚期癌症中的临床影响：系统性回顾和荟萃分析
F Kazmi,R Katyal,T F D Liu et al.
F Kazmi et al.
Aims: Precision oncology, driven by next-generation sequencing (NGS), enables the use of matched targeted therapies (MTTs) tailored to tumour-specific genomic alterations. While benefits in early-stage cancer are well-est...
Evaluation of Radiotherapy Plan Robustness: A Systematic Literature Review [0.03%]
放射治疗计划鲁棒性评价的系统文献回顾
S Kim,D Bernstein,A Taylor
S Kim
Aims: Advances in radiotherapy have led to increasingly conformal and complex treatment plans. The progressive reduction in safety margins around the target volume and the increased use of hypofractionated radiotherapy fu...
The Use of Molecular Tools for Identifying and Guiding Treatment of Cancers of Unknown Primary: A Systematic Review [0.03%]
分子工具在原发灶不明癌症的诊断和治疗中的应用：系统评价研究
S Saibil,X Yao,D Sivajohanathan et al.
S Saibil et al.
Background: Cancer of unknown primary (CUP) represents a significant clinical challenge due to its heterogeneity and the poor prognosis often associated with the disease. Molecular profiling has emerged as a promising app...
The BRAFV600E Mutation Enhances Age-Based Prognostic Stratification in Radioiodine-Treated Papillary Thyroid Cancer: A Retrospective Cohort Study [0.03%]
BRAF V600E突变可增强放射性碘治疗的分化型甲状腺癌的预后年龄分层：回顾性队列研究
J Cao,H Liang,X Li et al.
J Cao et al.
Aims: To evaluate whether BRAFV600E mutation status enhances the value of age in predicting clinical outcomes for papillary thyroid carcinoma (PTC) patients receiving radioactive iodide (RAI) therapy. ...
Quality of Decision-making at Oncology Multidisciplinary Team Meetings: A Structured Observational Study [0.03%]
肿瘤多学科团队会议中决策质量的结构化观察研究
Y Koo,J Shafiq,J Yanga et al.
Y Koo et al.
Aims: Multidisciplinary meetings (MDMs) are crucial in cancer care, with increasing attention on improving the quality of decision-making. Validated tools have been utilised to assess MDM performance internationally. Howe...
F Holt,R Simoes
F Holt
RT-HaND_C: A Multi-Source, Validated Real-world Head and Neck Cancer Dataset for Research [0.03%]
一种用于研究的多源、验证过的头颈癌真实世界数据集RT-HaND_C
T Young,H Drake,V Butterworth et al.
T Young et al.
Aims: Real-world data (RWD) are a valuable resource for head and neck cancer (HNC) research, offering insights into outcomes among diverse, comorbid patients who are often underrepresented in clinical trials. However, RWD...