Use of Telomere Length as a Biomarker in Idiopathic Pulmonary Fibrosis [0.03%]
端粒长度在特发性肺纤维化中的生物标志物作用
Caroline Dahlqvist,Thomas Planté-Bordeneuve,Trejsi Muca et al.
Caroline Dahlqvist et al.
Background: Telomere shortening, a hallmark of cellular aging, is associated with poor outcomes in idiopathic pulmonary fibrosis (IPF). This study aimed to explore the relationships between telomere length (TL), pulmonary...
Multicenter Study
Lung. 2025 Jul 9;203(1):78. DOI:10.1007/s00408-025-00830-6 2025
Electronic-Nose Technology for Lung Cancer Detection: A Non-Invasive Diagnostic Revolution [0.03%]
电子鼻技术在肺癌检测中的应用：一种无创诊断革命
A M Dhanush Gowda,Akanksha D Dessai,Usha Y Nayak
A M Dhanush Gowda
Background: Lung cancer (LC) remains a leading cause of cancer-related mortality worldwide, primarily due to late-stage diagnosis and the absence of effective early detection methods. ...
Effectiveness of Nintedanib in Progressive Pulmonary Fibrosis Assessed by Progression Criteria: An Italian, Observational, Multicenter Study [0.03%]
尼达尼布治疗进展性肺纤维化的有效性评估：一项意大利多中心观察性研究
Michele Mondoni,Francesco Varone,Fabrizio Luppi et al.
Michele Mondoni et al.
Purpose: Pulmonary fibrosis is defined as progressive based on the combination of radiological, clinical, and functional criteria. Nintedanib can reduce the rate of lung function decline, but no data are available on its ...
Observational Study
Lung. 2025 Jul 8;203(1):77. DOI:10.1007/s00408-025-00832-4 2025
Prophylactic Inhaled Antibiotics for Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis of Incidence and Mortality Outcomes [0.03%]
预防性吸入式抗生素用于呼吸机相关肺炎：发病率和死亡率结局的系统评价和meta分析
Carlos Valladares,Bryan Gregory,Sheilabi Seeburun et al.
Carlos Valladares et al.
Purpose: Ventilator-associated pneumonia (VAP) is a common ICU complication linked to high morbidity and mortality. Inhaled antibiotics may offer targeted prophylaxis, but their effectiveness has shown mixed results. This...
Meta-Analysis
Lung. 2025 Jul 5;203(1):75. DOI:10.1007/s00408-025-00827-1 2025
Lei Zhao,Ling Lei,Jiashi Guo et al.
Lei Zhao et al.
Purpose: Acute respiratory distress syndrome (ARDS)/Acute lung injury (ALI), characterized by severe hypoxemia and pulmonary edema, involves mitochondrial dysfunction. Cytidine/uridine monophosphate kinase 2 (Cmpk2), a mi...
The Advantages of FEV1 Percent Predicted Change During Bronchial Challenge Testing [0.03%]
预测FEV1变化百分比进行支气管激发试验的优势
James Dean,Augusta Beech,Dave Singh
James Dean
Background: The methacholine challenge requires a 20% fall in forced expiratory volume in one second (FEV1). The fall is measured as litre (L) change from the pre-challenge (baseline) value. A higher baseline FEV1 require...
Right Ventricular-Pulmonary Arterial Uncoupling Thresholds in Acute Pulmonary Embolism [0.03%]
急性肺栓塞右心室-肺动脉脱耦阈值
F Zeba,I Singh,J Gomez et al.
F Zeba et al.
Introduction/purpose: Right ventricle (RV) dysfunction in the setting of acute pulmonary embolism (PE) is associated with worse outcomes. The ratio of tricuspid annular plane systolic excursion (TAPSE) and pulmonary arter...
Genetic Factors Explain Half of the Individual Susceptibility to Chronic Bronchitis, Airflow Obstruction and COPD Regardless of the Spirometric Definition: A Nationwide Twin Study [0.03%]
遗传因素解释了慢性支气管炎、气流受限和慢阻肺个体易感性的半数比例：一项全国范围的双胞胎研究
Howraman Meteran,Simon Francis Thomsen,Jacob Hjelmborg et al.
Howraman Meteran et al.
Background: Smoking is a major risk factor for lung function decline and chronic obstructive pulmonary disease (COPD), but the individual susceptibility to these traits cannot be explained solely by environmental risk fac...
Overexpression of BPIFB4 Alleviates COPD Inflammatory Damage by Inhibiting M1 Macrophage Activation via the PI3K/AKT Pathway [0.03%]
BPIFB4过表达通过PI3K/AKT信号通路抑制M1型巨噬细胞活化从而缓解慢性阻塞性肺疾病炎症损伤
Lexin Xue,Jingran Xu,Hui Gong et al.
Lexin Xue et al.
Background: Macrophage polarization is essential for inflammatory regulation in COPD. The precise role of BPI Fold-Containing Family B Member 4 (BPIFB4) in regulating the inflammatory processes underlying COPD pathogenesi...