Alteration of the Secretome in Airway Epithelial Cells by Air Pollutants: Evidence from an Air-Liquid Interface Model [0.03%]
污染物对空气道上皮细胞分泌组的影响：来自气液界面模型的证据
Hankun Lu,Jiahui Xiang,Xiaoyu Zhou et al.
Hankun Lu et al.
Introduction: While the structural damage to the airway epithelium from ozone (O₃) or diesel exhaust particles (DEP) is known, the common regulatory mechanisms activated during mixed exposures, which mirror real-world sc...
The Healthcare Resource Utilization of Patients with Refractory Chronic Cough Compared to Those with Non-Refractory Chronic Cough [0.03%]
难治性和非难治性慢性咳嗽患者的医疗资源利用对比研究
Laurent Guilleminault,Clairelyne Dupin,Laurent Portel et al.
Laurent Guilleminault et al.
Background: Refractory chronic cough (RCC) significantly impairs patient quality of life and poses a major challenge in clinical management. However, little is known about the healthcare resource utilization (HRU) of pati...
Comparative Study
Lung. 2025 Oct 4;203(1):97. DOI:10.1007/s00408-025-00853-z 2025
The Down-Regulation of Lactoferrin Expression Induced by Cigarette Smoke can Induce Ferroptosis in COPD [0.03%]
吸烟通过下调乳铁蛋白诱导COPD铁死亡发生
Yuxiu Wang,Wenjing Xu,Kaiqi Ren et al.
Yuxiu Wang et al.
Purpose: Lactoferrin (LTF) plays a crucial role in iron homeostasis, immune response, and inflammation. In the context of chronic obstructive pulmonary disease (COPD), LTF's expression is significantly influenced by envir...
FUNDC1 Promoted Ferroptosis via JNK Pathway in Cigarette Smoking-Induced Chronic Obstructive Pulmonary Disease [0.03%]
基金C1通过JNK途径促进香烟吸烟引起的慢性阻塞性肺疾病中铁死亡发生
Yi Feng,Jiali Weng,Chenfei Li et al.
Yi Feng et al.
Background: Cigarette smoking (CS), the major risk factor for chronic obstructive pulmonary disease (COPD), induces oxidative stress, mitophagy, and ferroptosis. Because FUN14 domain-containing protein 1 (FUNDC1), a mitop...
Lactate and Lactylation in Respiratory Diseases: from Molecular Mechanisms to Targeted Strategies [0.03%]
呼吸系统疾病中的乳酸与乳酰化：从分子机制到靶向策略
Qi Jia,Quan Yuan,Xiangdong Chen et al.
Qi Jia et al.
Introduction: Lactate has emerged as a multifunctional signaling molecule regulating various physiological and pathological processes. Furthermore, lactylation, a newly identified posttranslational modification triggered ...
Neuroinflammatory Consequences of Rhinovirus Infection in Human Epithelial and Neuronal Models [0.03%]
人呼吸道上皮和神经元模型中的鼻病毒感染的神经炎症后果
Orla M Dunne,Nicola A M Roe,Aurélie Mousnier et al.
Orla M Dunne et al.
Introduction: Rhinovirus (RV) is the leading cause of exacerbations of lung disease. A sensory neuronal model, derived from human dental pulp stem cells and differentiated into peripheral neuronal equivalents (PNEs), was ...
Age-Dependent Risk of Bronchial Asthma Exacerbation in Respiratory Syncytial Virus Co-infection [0.03%]
呼吸道合胞病毒共感染者的支气管哮喘加重风险的年龄依赖性
Ken Arimura,Keiko Kan-O,Yasuto Sato et al.
Ken Arimura et al.
Introduction: Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are common viral etiologies of respiratory infections. Although co-infection with other respiratory pathogens is frequently observed, its cl...
Emerging Therapeutics in COPD: Mapping Innovation to Treatable Traits [0.03%]
COPD新兴治疗药物：将创新疗法与可治疗特征匹配
Mario Cazzola,Vanessa M McDonald,Daiana Stolz et al.
Mario Cazzola et al.
Chronic Obstructive Pulmonary Disease (COPD) is a complex, heterogeneous condition characterized by diverse clinical phenotypes and underlying pathobiological mechanisms. Traditional "one-size-fits-all" management strategies have limited ef...
Changes in Lung Function and Patient-Reported Outcomes in Patients with Idiopathic Pulmonary Fibrosis [0.03%]
特发性肺纤维化患者的肺功能及患者报告结果的变化趋势分析
Jamie L Todd,Megan L Neely,Anne S Hellkamp et al.
Jamie L Todd et al.
We evaluated relationships between changes in lung function and changes in patient-reported outcomes (PROs) in 736 patients with idiopathic pulmonary fibrosis (IPF) enrolled in the IPF-PRO Registry. Weak correlations were observed between c...
Sputum Transcriptomic Analysis and Clustering Reveals Insight Into Asthma Heterogeneity [0.03%]
支气管哮喘 transcriptomic 分析与聚类揭示其异质性特征
Janne Goossens,Anne-Charlotte Jonckheere,Sien De Boodt et al.
Janne Goossens et al.
Introduction: Asthma is a heterogenous disease shaped by different inflammatory pathways. The aim is to investigate transcriptomic profiles in asthmatic patients and associate these with inflammation, airway damage and lu...
Observational Study
Lung. 2025 Aug 20;203(1):89. DOI:10.1007/s00408-025-00843-1 2025