Leyu Hong,Ming Ni,Fei Xue et al.
Leyu Hong et al.
Histone deacetylases (HDACs), a class of enzymes involved in epigenetic modifications, play a pivotal role in modulating chromatin structure and gene expression. Among these, histone deacetylase 3 (HDAC3) has emerged as a key regulator in d...
Serum Soluble Toll-Like Receptor 4 is a Predictive Biomarker for Acute Exacerbation and Prognosis of Idiopathic Pulmonary Fibrosis: A Retrospective Study [0.03%]
血清可溶性Toll样受体4是特发性肺纤维化急性加重和预后的预测生物标志物：一项回顾性研究
Erika Kitadai,Kakuhiro Yamaguchi,Hiroshi Iwamoto et al.
Erika Kitadai et al.
Purpose: Toll-like receptor 4 (TLR4) is a transmembrane receptor promoting pro-inflammatory signalling, that is associated with the pathogenesis of pulmonary fibrosis. TLR4 is abundantly expressed on monocytes and the acc...
MIP-3-Alpha and MIP-3-Beta as Early Predictors of Pneumonia in Polytraumatized Patients [0.03%]
创伤性多发伤患者肺炎早期预测指标MIP-3-Alpha和MIP-3-Beta
Gregor Wollner,Florian Hruska,Paul Ettel et al.
Gregor Wollner et al.
Introduction: Pneumonia is one of the most common complications in patients suffering multiple traumas and is associated with an exceptionally high mortality rate. MIP-3-alpha and MIP-3-beta are pro-inflammatory chemokine...
Supratherapeutic Inhaled Corticosteroid Use in Patients Initiating on Biologic Therapies for Severe Asthma: A Nationwide Cohort Study [0.03%]
启动生物疗法的严重哮喘患者中超剂量吸入皮质类固醇的应用：全国队列研究
Frederikke Hjortdahl,Marianne Baastrup Soendergaard,Susanne Hansen et al.
Frederikke Hjortdahl et al.
Background: In severe asthma, intensive ("supratherapeutic") doses of inhaled corticosteroids (ICS) are often used. The prevalence of supratherapeutic ICS use and its impact on corticosteroid-related comorbidities is poor...
Yu Jin Lee,Mi Na Kim,Eun Gyul Kim et al.
Yu Jin Lee et al.
Purpose: Oxygen therapy is helpful for patients with breathing difficulties; however, sustained supplementation with high-concentration oxygen can cause hyperoxic acute lung injury. Sirtuin 2 (SIRT2), a nicotinamide adeni...
Predictors of Long-Term Survival in Patients with Idiopathic Pulmonary Fibrosis: Data from the IPF-PRO Registry [0.03%]
特发性肺纤维化患者长期生存的预测因素：IPF-PRO 注册中心的数据
Hyun J Kim,Jeremy M Weber,Megan L Neely et al.
Hyun J Kim et al.
Purpose: We used data from the IPF-PRO Registry of patients with idiopathic pulmonary fibrosis (IPF) to identify characteristics that predicted survival for a further > 5 years. ...
FLRT3 Overexpression Attenuates Ischemia-Reperfusion Induced Vascular Hyperpermeability and Lung Injury Through RND3 [0.03%]
FLRT3过表达通过RND3减弱缺血-再灌注诱导的血管通透性和肺损伤
Yongmei Cao,Shiyang Sheng,Yong Zhong et al.
Yongmei Cao et al.
Purpose: Pulmonary ischemia/reperfusion injury (IRI) causes endothelial barrier dysfunction and increased vascular permeability. Fibronectin leucine-rich transmembrane protein-3 (FLRT3) is known to regulate endothelial ce...
Toll-Like Receptor 4 and 8 are Overexpressed in Lung Biopsies of Human Non-small Cell Lung Carcinoma [0.03%]
非小细胞肺癌肺活检中TLR4和TLR8过表达
Silvia Ceccarelli,Viola Pasqua Marzolesi,Jacopo Vannucci et al.
Silvia Ceccarelli et al.
Purpose: Lung cancer is the leading cause of cancer death worldwide which includes two main types of carcinoma distinguished in non-small cell lung cancer (NSCLC) involving epithelial cells, and small cell lung cancer (SC...
Differences in Blood Eosinophil Level During Stable Disease and During Exacerbation of COPD and Exacerbation Risks [0.03%]
在慢性阻塞性肺病稳定期和急性加重期时血液嗜酸性粒细胞水平的差异及其对疾病风险的影响
Wang Chun Kwok,Terence Chi Chun Tam,Chi Hung Chau et al.
Wang Chun Kwok et al.
Background: Although blood eosinophil count (BEC) has been extensively studied as a biomarker in chronic obstructive pulmonary disease (COPD), there remain challenges and controversy in using a single reading. It has not ...
Oxidative Stress and Epithelial-Mesenchymal Transition: The Impact of Ubiquitin C-terminal Hydrolase L1 in Cigarette Smoke-Induced COPD [0.03%]
氧化应激和上皮间充质转化：泛素C末端水解酶L1在香烟烟雾诱导的慢性阻塞性肺疾病中的影响
Jing Jing Yang,Hong Jun Liu,Yu Xiu Wang et al.
Jing Jing Yang et al.
Purpose: Cigarette smoke (CS) has been demonstrated to mediate oxidative stress (OS) and epithelial-mesenchymal transition (EMT) in bronchial epithelial cells, thereby contributing to airway remodeling in chronic obstruct...