Enterotype-specific microbial biomarkers of immune checkpoint inhibitor response revealed by large-scale integrated metagenomic analysis [0.03%]
基于大规模综合宏基因组分析揭示反应免疫检查点抑制剂的肠型特异性微生物生物标志物
Francesco Candeliere,Enrico Busi,Sara Cerri et al.
Francesco Candeliere et al.
The gut microbiota appears to play a critical role in modulating antitumor immune responses and influencing the efficacy of cancer immunotherapy drugs such as immune checkpoint inhibitors. However, the identification of consistent microbial...
IAR025, a novel anti-DLL3 x CD3-bispecific antibody, displays high antitumor efficacy in preclinical models of small-cell lung cancer [0.03%]
一种新型抗DLL3×CD3双特异性抗体IAR025在小细胞肺癌的临床前模型中表现出高效的抗肿瘤作用
Yang Liu,Lei Cao,Mengqiu Xu et al.
Yang Liu et al.
Small-cell lung cancer (SCLC) is one of the most aggressive subtype of lung carcinoma with limited treatment options. Delta-like ligand 3 (DLL3), a Notch ligand protein, has been an attractive target for SCLC due to its high expression on S...
Role of the Wnt5A pathway in resistance to immune checkpoint inhibitors in advanced Non-Small Cell Lung Cancer [0.03%]
Wnt5A通路在晚期非小细胞肺癌免疫检查点抑制剂耐药中的作用
Paul Takam Kamga,Adrien Costantini,Claude Capron et al.
Paul Takam Kamga et al.
Background: β-catenin-independent Wnt signaling plays a role in lung carcinogenesis, but its impact on prognosis and immune response in Non-Small Cell Lung Cancer (NSCLC) patients receiving immune checkpoint inhibitors (...
Real-world efficacy and safety of immune checkpoint blockades in advanced urothelial carcinoma with histologic variant subtypes: the pembroblad study [0.03%]
免疫检查点抑制剂治疗变异型亚型尿路上皮癌的疗效和安全性：PembroBlad研究
Karim Amrane,Luca Campedel,Fabien Moinard-Butot et al.
Karim Amrane et al.
Background: Histologic variants (HV) of urothelial carcinoma (UC-V) and non-urothelial carcinomas (NUC) of the bladder and urinary tract are aggressive malignancies with poor prognosis and limited response to platinum-bas...
GFI1 enhances MHC-I expression in tumor cells and augments tumor responsiveness to PD-1/PD-L1 inhibitors [0.03%]
GFI1通过增强肿瘤细胞MHC-I表达提高PD-1/PD-L1抑制剂的抗肿瘤疗效
Yu Xi,Kewei Xiao,Kelin Meng et al.
Yu Xi et al.
Background: Growth factor-independent-1 transcription repressor (GFI1) is crucial for determining the differentiation and fate of exhausted CD8+ T cells and affects immunotherapy outcomes. However, the effects of tumor ce...
TGF-β inhibition enhances anti-tumor immunity and sensitizes PD-1 blockade therapy of bone marrow-derived myofibroblasts-induced "immunotherapy resistance" tumor model [0.03%]
转化生长因子-β抑制增强抗肿瘤免疫并使骨髓来源肌成纤维细胞诱导的“免疫治疗抵抗”肿瘤模型对PD-1阻断疗法敏感化
Xin Cheng,Lina He,Cong Zhou et al.
Xin Cheng et al.
Resistance to immune checkpoint blockade (ICB) therapy in certain solid tumors remains a major research focus; yet, the underlying mechanisms are not fully understood. Our previous studies demonstrated that subcutaneous tumors formed by a m...
Overcoming resistance in CD44-overexpressing myeloma through combination therapy with ATRA, bortezomib, and NK cells [0.03%]
通过联合使用ATRA、硼替佐米和NK细胞克服CD44高表达多发性骨髓瘤的耐药性
Van-Tan Nguyen,Thuy Nguyen Thi,Van-Dinh-Huan Tran et al.
Van-Tan Nguyen et al.
CD44 is a cell-surface glycoprotein frequently overexpressed in cancers and associated with poor prognosis. We evaluated the prognostic significance of CD44 overexpression in multiple myeloma (MM) and investigated the therapeutic efficacy o...
β-hydroxybutyrate potentiates anti-tumor immunity by modulating cytotoxic CD8+ T cell responses [0.03%]
β-羟丁酸通过调节细胞毒性CD8⁺T细胞的反应来增强抗肿瘤免疫
Yupan Bai,Han Xue,Yujie Bao et al.
Yupan Bai et al.
Ketogenic diets (KDs) have been reported to influence tumor progression through metabolic and immunological modulation of the tumor microenvironment. β-hydroxybutyrate (βOHB), the predominant ketone body elevated by KD, functions not only...
Cytokine-induced killer (CIK) Cells-associated transcriptome signature reveals the potential immunomodulatory role of TNFSF14 in clear cell renal cell carcinoma [0.03%]
细胞因子诱导的杀伤(CIK)细胞相关转录组特征揭示了TNFSF14在透明细胞肾细胞癌中的潜在免疫调节作用
Yinhao Chen,Linli Chen,Xinyue Qin et al.
Yinhao Chen et al.
Among adoptive immune cell therapies, cytokine-induced killer cell (CIK) therapy has demonstrated clear therapeutic relevance in multiple cancers, particularly clear cell renal cell carcinoma (ccRCC). Despite being clinically successful, th...
Vorinostat unmasks MAEL to enhance DC vaccine-induced CTL killing in hepatocellular carcinoma, potentiated by TIGIT checkpoint inhibition [0.03%]
伏立诺他通过解除MAEL抑制增强DC疫苗诱导的CTL杀伤作用以治疗肝细胞癌，TIGIT检查点抑制可促进其疗效
Can Liu,Qianru Zhang,Jingjing Zhang et al.
Can Liu et al.
Background: To address the limited immunogenicity and immune evasion in hepatocellular carcinoma (HCC), this study developed a combinatorial immunotherapy strategy combining antigen-specific vaccination, epigenetic modula...