Immune-cold NSCLC tumors harbor tumor-associated macrophages with elevated expression of immunoglobulin genes [0.03%]
免疫低反应的非小细胞肺癌肿瘤中含有免疫球蛋白基因表达水平升高的肿瘤相关巨噬细胞
Markus Haug,Henrik Sahlin Pettersen,Magne Børset et al.
Markus Haug et al.
In the non-small cell lung cancer (NSCLC) tumor microenvironment (TME), tumor cells mediate inhibitory signals to key immune cells, promoting an immunosuppressive environment that facilitates tumor immune evasion. CD8 + cytotoxic T lymphocy...
Explainable AI reveals squamous histology and U-shaped PD-L1 patterns as primary subgroup predictors of neoadjuvant and perioperative immunotherapy benefit in NSCLC: a machine learning analysis [0.03%]
可解释的人工智能揭示了非鳞状组织学和U型PD-L1模式作为新辅助和围手术期免疫治疗受益的主要亚组预测因子：机器学习分析肺癌患者数据的研究
Fangfang Shen,Zheqing Zhu,Junge Liu et al.
Fangfang Shen et al.
Background: The introduction of neoadjuvant and perioperative immunotherapy has broadened treatment options for resectable non-small cell lung cancer (NSCLC). However, clinical benefit varies across subpopulations, and st...
Pan-cancer single-cell and spatial transcriptomics analyses delineate response-associated heterogeneity and therapeutic targets of tumor-infiltrating B cells following immune checkpoint blockade [0.03%]
泛癌单细胞和空间转录组分析揭示了免疫检查点抑制后肿瘤浸润B细胞的反应相关异质性和治疗靶点
Jialing Fang,Hangyu Liu,Jun Lei et al.
Jialing Fang et al.
Tumor-infiltrating B cells (TIBs) are emerging as central regulators of anti-tumor immunity, but their biological functions, spatial niches, and cross talk with tumor-infiltrating lymphocytes vary widely across cancer types, particularly wi...
Enhanced PD-L1 targeting boosts the cytotoxic activity of FOLR1- CAR NK92 cells against ovarian cancer [0.03%]
增强PD-L1靶向性可提高FOLR1-CAR NK92细胞对卵巢癌的细胞毒性作用
Xuena Chen,Jie Huang,Ge Diao et al.
Xuena Chen et al.
Chimeric antigen receptor (CAR)-T cells have achieved remarkable success against hematologic malignancies; however, their application is associated with risks such as cytokine release syndrome (CRS) and neurotoxicity. In contrast, CAR-NK ce...
Integrated immunophenotypic and ProMisE molecular profiling as predictors of immune checkpoint inhibitor response in recurrent endometrial cancer [0.03%]
联合免疫表型和ProMisE分子分型预测复发性子宫内膜癌对免疫检查点抑制剂的反应
Komei Katayama,Nobuhisa Yoshikawa,Wenting Liu et al.
Komei Katayama et al.
Background: Immune checkpoint inhibitors (ICIs) are an important treatment option for recurrent endometrial cancer (EC); however, responses vary widely. Although the ProMisE molecular classification provides prognostic an...
Preclinical evaluation of rBCG-h12: an engineered Bacillus Calmette-Guérin with an enhanced activity against bladder and pancreatic cancers [0.03%]
改良结核菌用于膀胱癌和胰腺癌治疗的临床前评估研究
Chang-Ching Yeh,Chi-Shuan Fan,Li-Li Chen et al.
Chang-Ching Yeh et al.
Background: Intravesical Bacillus Calmette-Guérin (BCG) therapy has been the standard treatment for preventing recurrence of non-muscle-invasive bladder cancer (NMIBC) for over four decades. Although maintenance BCG ther...
A novel oncolytic herpes simplex virus type 2 induces polarization of tumor-associated macrophages and remodels the immune microenvironment in glioblastoma [0.03%]
一种新型溶瘤单纯疱疹病毒2型诱导胶质母细胞瘤肿瘤相关巨噬细胞极化并重塑免疫微环境
Xin Yang,Shenglan Li,Yanjie Lan et al.
Xin Yang et al.
Background: Glioblastoma multiforme (GBM) is a highly aggressive primary malignant brain tumor with limited survival despite multimodal therapy. Its profoundly immunosuppressive tumor microenvironment severely restricts t...
Spatial transcriptomics of cervical cancer reveals microenvironment shaped the malignant epithelial programs and ECM-associated immune niches [0.03%]
空间转录组揭示宫颈癌微环境塑造恶性上皮程序和细胞外基质相关免疫生态位
Qing Chen,Jinli Lyu,Yu Li et al.
Qing Chen et al.
Objectives: Cervical cancer progression and therapeutic response are influenced by intratumoral heterogeneity and the tumor microenvironment. The diversity of malignant epithelial subtypes and their interactions with immu...
Pertussis toxin-induced lymphocytosis shifts the tumor microenvironment toward immune activation via CXCL9 signaling [0.03%]
百日咳毒素通过CXCL9信号诱导淋巴细胞增多从而将肿瘤微环境向免疫活化转变
Jae-Keun Cho,Kyungmin Lee,Da-Yong Shin et al.
Jae-Keun Cho et al.
Background: A decrease in peripheral lymphocyte count in cancer patients predicts poorer prognosis and can be a useful discriminator in response to anti-tumor immunotherapy. However, therapeutic interventions to induce ly...
Flow-cytometric profiling of large extracellular vesicles as immunophenotypic biomarkers in head and neck squamous cell carcinoma [0.03%]
头颈鳞状细胞癌中作为免疫表型生物标志物的大胞外囊泡的流式细胞术分析
Judith Büntzel,Markus Maulhardt,Alexander Casimir Angleitner et al.
Judith Büntzel et al.
Background: Large extracellular vesicles (large EV) released from tumor and benign cells are detectable in blood and hold potential as non-invasive biomarkers. While their diagnostic relevance has been shown in several ma...