EGFRxCD16 bispecific antibodies orchestrate superior NK cell-mediated lysis of ovarian cancer and NSCLC cell lines in combination with oncolytic viruses [0.03%]
EGFR-CD16双特异性抗体联合溶瘤病毒对卵巢癌和非小细胞肺癌细胞系的杀伤作用
Sarah Gahbauer,Thomas Poiret
Sarah Gahbauer
Combination therapy integrating bispecific antibody (BsAb) and oncolytic viruses (OVs) to enhance antitumor immune response offers a promising therapeutic approach in comparison with OV treatment alone. This study aims to strengthen and cha...
Multidimensional analysis of tumour immune microenvironment in HCC: prognostic significance and implications for immunotherapy [0.03%]
肝癌肿瘤免疫微环境的多维度分析及其预后意义和免疫治疗启示
Jun Chen,Mingzhen Zhou,Wenyan Cao et al.
Jun Chen et al.
Background: The combination of immune checkpoint inhibitors (ICIs) and anti-angiogenic agents represents the standard first-line therapy for patients with unresectable hepatocellular carcinoma (HCC). However, most patient...
Transcriptomic landscape of peripheral T cells following CAR-T cell therapy in diffuse large B cell lymphoma [0.03%]
弥漫性大B细胞淋巴瘤接受CAR-T细胞治疗后外周T细胞转录组谱系分析
Ismael de la Iglesia-San Sebastián,Sara Fernández de Córdoba-Oñate,Mariana Bastos-Oreiro et al.
Ismael de la Iglesia-San Sebastián et al.
Background: CAR-T cell therapy has improved outcomes in relapsed/refractory large B cell lymphoma (LBCL), yet responses remain variable; baseline endogenous T cell state and post-infusion CAR-T differentiation may contrib...
HMGB1 ubiquitination inhibition and extracellular secretion, mediated by m6A modified-exosomal lncRNA MALAT1, creates a communication between NK92-MI cells and tumor cells to aggravate acute lymphoblastic leukemia [0.03%]
通过m6A修饰的外泌体长链非编码RNA MALAT1介导的HMGB1泛素化抑制和细胞外分泌，NK92-MI细胞与肿瘤细胞之间建立了一种通讯方式从而促进急性淋巴细胞白血病的发展恶化
Xiaofang Hong,Daiyan Yang,Jianhao Xing et al.
Xiaofang Hong et al.
Background: MALAT1 has been validated to favor the progression of acute lymphoblastic leukemia (ALL), but its detailed mechanism remains obscure. This study explored the functional roles of ALL cells-derived exosomal MALA...
R-5780, a SagA-engineered Lactococcus lactis, is a safe oral synthetic-biology microbial therapy that potentiates PD-1 blockade [0.03%]
基因重组的工程细菌R-5780可增强PD-1抑制剂的功效用于癌症免疫治疗
Miaki Fukuhara,Bikash Sahay,Gary R Fanger et al.
Miaki Fukuhara et al.
Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1) have transformed cancer therapy, yet response rates remain limited across solid tumors. Modulation of the gut microbiome has emerged as a promising strateg...
Downregulation of ANKRD22 promotes ovarian cancer cell proliferation by enhancing the immunosuppressive capacity of M-MDSCs [0.03%]
ANKRD22低表达通过增强M-MDSCs的免疫抑制能力促进卵巢癌细胞增殖
Huanhuan Chen,Tianhui Pan,Qionghua He et al.
Huanhuan Chen et al.
ANKRD22 is a protein involved in tumor immune regulation. To elucidate its role in ovarian cancer, we analyzed its expression pattern and association with the tumor immune microenvironment. Bioinformatics analyses revealed upregulation of A...
The microbiota-lymphocyte protective axis (MLPA): a novel paradigm for overcoming radiation-induced lymphopenia (RIL) and potentiating the efficacy of tumor immuno-combination therapy [0.03%]
微生态系统-淋巴细胞保护轴（MLPA）：克服放射性淋巴细胞减少症和增强肿瘤免疫联合治疗功效的新范例
Yilin Chen,Shuaixuan Chen,Hang Zhang et al.
Yilin Chen et al.
Combination therapy involving radiotherapy and immune checkpoint inhibitors has become a cornerstone of modern oncology; however, its therapeutic efficacy is frequently compromised by radiation-induced lymphopenia, a phenomenon traditionall...
Timing of immune checkpoint inhibitors infusion and prognosis in recurrent/metastatic nasopharyngeal carcinoma: a single-center, retrospective study [0.03%]
免疫检查点抑制剂在复发/转移性鼻咽癌中的用药时机与预后之间的关系：一项单中心回顾性研究
Lin Zhang,Xia Gan,Zhengzheng Yu et al.
Lin Zhang et al.
Background: The timing of immunotherapy administration has been linked to variations in clinical outcome across multiple cancers, but its effect on clinical outcome in nasopharyngeal carcinoma (NPC) remains unstudied. ...
CD68+ tumor-associated macrophages exhibit prognostic value in surgically resected small cell lung cancer: a retrospective cohort study of 614 patients [0.03%]
CD68阳性肿瘤相关巨噬细胞在614例小细胞肺癌患者手术标本中的预后价值：回顾性队列研究
Ruijie Ma,Hengjia Tu,Xingwu Wang et al.
Ruijie Ma et al.
Background: Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment (TME) in small cell lung cancer (SCLC), yet the clinicopathological and prognostic relevance of CD68+ TAM infiltration in su...
Regulatory B-cell states in NSCLC immunotherapy resistance: mechanisms, spatial context and translational implications [0.03%]
非小细胞肺癌免疫治疗耐药的Bregs调控机制、空间定位及其转化意义研究
Xin Wang,Xi Li,Jing Zhou et al.
Xin Wang et al.
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide. Although immune checkpoint inhibitors (ICIs) have improved clinical outcomes, durable benefit is limited by primary and acquired resistance ar...