Safety and feasibility of 5T4 antibody-coupled allogeneic NK cell therapy for solid tumors: a first-in-human phase 1 trial [0.03%]
一项针对实体瘤的5T4抗体耦联同种异体NK细胞疗法的安全性和可行性I期临床试验：首个人体试验
Liangjie Sun,Peiwen Ma,Zhenwei Miao et al.
Liangjie Sun et al.
Background: Patients with unresectable locally advanced or metastatic solid tumors have limited therapeutic options. Antibody-guided allogeneic natural killer (NK) cell therapy represents a novel immunotherapeutic strateg...
Time-dependent cytokine landscapes in an ex vivo microfluidic glioblastoma platform [0.03%]
具有时间依赖性细胞因子景观的体外微流控胶质母细胞瘤模型
Amr Moursi,Antonia Barry,Lauric Feugere et al.
Amr Moursi et al.
Glioblastoma (GBM) is the most common and aggressive astrocytic glioma of the central nervous system with a median survival of 15 months from diagnosis. Patient outcomes have improved only marginally over the past 20 years, and GBM research...
Correction: Repurposing public sarcoma multi-omics for neoantigen discovery [0.03%]
纠正：重新利用公共肉瘤多组学数据进行新抗原发现
Panagiotis Mantas,Karen A Krogfelt
Panagiotis Mantas
Published Erratum
Cancer immunology, immunotherapy : CII. 2026 Jul 4;75(7):179. DOI:10.1007/s00262-026-04469-x 2026
A low-dose self-amplifying mRNA vaccine encoding HPV16 E6/E7 induces potent T-cell immunity and antitumor protection in mice [0.03%]
一种低剂量的自我放大型HPV16E6 / E7编码mRNA疫苗可诱导小鼠产生有效的T细胞免疫和抗肿瘤保护作用
Rui Xing,Shanshan Wang,Yixin Wang et al.
Rui Xing et al.
Background: Human papillomavirus (HPV), particularly high-risk types such as HPV16, is associated with several malignancies, including cervical cancer. Existing therapeutic vaccines targeting HPV oncoproteins E6 and E7 sh...
GLP-1 receptor agonists at immune checkpoint inhibitor initiation with immune-related and supportive-care outcomes in patients with cancer and overweight or obesity without diabetes: a target trial emulation [0.03%]
在未患糖尿病的癌症患者中，在使用免疫检查点抑制剂治疗时启动胰高血糖素样肽-1受体激动剂与免疫相关和支持性护理结果之间的关系：靶标试验模拟研究
Yu-Jung Lin,Pei-Yun Li,Shao-Chia Chen et al.
Yu-Jung Lin et al.
Aims: Sarcopenia, cachexia, and malnutrition are common in patients on immune checkpoint inhibitors (ICIs). GLP-1 receptor agonists (GLP-1 RAs) are increasingly used for weight management in patients with obesity, includi...
Macrophage heterogeneity in breast cancer microenvironment and development of a prognostic model: exploring TFF1 as a novel therapeutic target [0.03%]
乳腺肿瘤微环境小凹素阳性巨噬细胞异质性与预后模型的建立及TFF1作为潜在治疗靶点的作用机制探索
Lin Chen,Zhiqiang Chen,Bailu Shi et al.
Lin Chen et al.
Backgrounds: Breast cancer (BRCA) represents the most prevalent malignancy globally, with projections indicating 3.2 million new cases anticipated by 2050. Current treatment modalities, encompassing surgical intervention,...
The increased co-expression of SLC7A11 and PD-L1 was associated with poor prognosis in extranodal natural killer T-cell lymphoma patients [0.03%]
SLC7A11和PD-L1的共表达增加与结外鼻型T细胞淋巴瘤患者的预后不良相关
Cuiying He,Yingzhen Yao,Xiaolin Wu et al.
Cuiying He et al.
Extranodal natural killer/T‑cell lymphoma (ENKTL) is a highly aggressive type of mature T and NK cell lymphoma that faces treatment challenges. Although immune checkpoint inhibitors (ICIs) have shown clinical activity in ENKTL, primary res...
Integrative single-cell and multi-omics analysis of ZBTB21-mediated serine metabolism in colorectal cancer: from metabolic reprogramming to immune microenvironment modulation [0.03%]
ZBTB21介导的结直肠癌丝氨酸代谢的整合单细胞和多组学分析：从代谢重塑到免疫微环境调节
Yimei Jiang,Haiyan Huang,Haoran Feng et al.
Yimei Jiang et al.
Background: Colorectal cancer (CRC) exhibits pronounced biological diversity, a feature increasingly attributed to alterations in cellular metabolic reprograms. Serine metabolism supports nucleotide synthesis, redox balan...
NKG2A-HLA-E and TIM3-galectin 9 pathways promote immune inhibition and represent therapeutic vulnerabilities in pancreatic ductal adenocarcinoma [0.03%]
NKG2A-HLA-E和TIM3-半乳糖凝集素9途径促进胰腺导管腺癌的免疫抑制并成为治疗靶点
Yuanyu Lin,Wanhua Feng,Yan Li et al.
Yuanyu Lin et al.
Background: The roles of NKG2A-HLA-E and TIM3-galectin 9 immune checkpoint pathways in pancreatic ductal adenocarcinoma (PDAC) progression remain incompletely characterized. This study investigates their contributions to ...
Integrative analysis of small cell carcinoma of the uterine cervix reveals its heterogeneity and provides novel predictive markers [0.03%]
整合分析揭示微小细胞宫颈癌的异质性并提供新的预测标志物
Qingxin Zhang,Jianjiang Fu,Liuying Zhong et al.
Qingxin Zhang et al.
Small cell carcinoma of the uterine cervix (UCSCC) is a rare and aggressive HPV-linked neuroendocrine malignancy with limited therapeutic options and poor prognosis. Through integrative analysis of whole-exome sequencing (WES), single-cell ...