Effectiveness and safety of enfortumab vedotin and pembrolizumab in a real-world patient population with urothelial carcinoma: results from a multi-institutional cohort (GUARDIANS) [0.03%]
恩沃单抗和帕博利珠单抗在真实世界尿路上皮癌患者中的有效性和安全性：一项多中心队列（GUARDIANS）研究结果
Stefanie Zschäbitz,Irfan Bhatti,Jozefina Casuscelli et al.
Stefanie Zschäbitz et al.
Introduction: Enfortumab vedotin plus pembrolizumab (EVP) is the standard first-line treatment for metastatic or locally advanced urothelial carcinoma (m/laUC). Real-world patients frequently present with unfavorable clin...
Correction: APC-targeted DNA vaccines: the role of CCL19 in immune cell recruitment and early onset of the immune response [0.03%]
关于APC靶向DNA疫苗的订正：CCL19在免疫细胞招募和早期免疫反应中的作用
Marina Barrio-Calvo,Stine Friis,Søren Vester Kofoed et al.
Marina Barrio-Calvo et al.
Association between cumulative lifetime exposure to reproductive hormones and tumor-infiltrating lymphocytes, CD4 +, and CD8 + T cells among women with breast cancer [0.03%]
绝经后乳腺癌患者体内累积一生暴露于生殖激素与肿瘤浸润淋巴细胞、CD4+和CD8+T细胞之间的关系
Yidan Zhang,Rand T Akasheh,Angela R Omilian et al.
Yidan Zhang et al.
Background: Reproductive hormones may influence immune responses to tumors. Tumor-infiltrating lymphocytes (TILs), CD4 +, and CD8 + T cell densities are markers of immune activity and breast cancer prognosis. We examined ...
Efficacy of checkpoint inhibitors in genitourinary cancers with advanced chronic kidney disease [0.03%]
检查点抑制剂在晚期慢性肾脏病泌尿生殖系统癌症中的疗效
Yin-Shen Chen,Chia-Cheng Yu,Renin Chang et al.
Yin-Shen Chen et al.
Background: Immunological checkpoint inhibitors (ICIs) have shown promise in treating various malignancies but are understudied in genitourinary cancers among patients with advanced chronic kidney disease (CKD), who are t...
Intracranially injected chimeric antigen receptor T cells eradicate glioblastoma cells but have limited potential to persist in the brain in a syngeneic mouse model [0.03%]
嵌合抗原受体T细胞能清除颅内注射的胶质母细胞瘤细胞，但在同基因鼠模型中在脑内的存活能力有限
Koki Murakami,Noriyuki Kijima,Hideki Kuroda et al.
Koki Murakami et al.
Glioblastoma multiforme (GBM) is among the most malignant primary brain tumors, necessitating the development of novel therapies. Intracranial injection of chimeric antigen receptor (CAR)-T cell therapy is effective against GBM. However, wh...
Real-world treatment patterns and early outcomes in advanced intrahepatic cholangiocarcinoma: a descriptive case series [0.03%]
晚期肝内胆管癌的现实世界治疗模式及早期结果：描述性病例系列
Runze Yu,Hong Zhao,Dong Yan
Runze Yu
Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis, with 70-80% of patients presenting advanced/metastatic disease. Conventional first-line chemotherapies have limitations, and targeted-immunotherapy combinations need real-world val...
CXCL13-CXCR5 signaling in CD8+ T cell recruitment and lymphoid immune organization in clear cell renal cell carcinoma [0.03%]
透明细胞肾细胞癌中CD8+t细胞募集和淋巴组织免疫组织的cxcl13-cxcr5信号转导路径
Daniel D Shapiro,Kye D Nichols,Moon Hee Lee et al.
Daniel D Shapiro et al.
Clear cell renal cell carcinoma (ccRCC) exhibits heterogeneity in immune infiltration and clinical outcomes, but the mechanisms governing recruitment and organization of tumor-reactive CD8+ T cells remain incompletely defined. We investigat...
Conserved minimal CD8 cytotoxic immune-state unit in an IL18R1-associated immune program in hepatocellular carcinoma [0.03%]
肝细胞癌中与IL18R1相关的免疫程序中的保守最小CD8细胞毒性免疫状态单位
Masamichi Kimura,Koji Nishikawa,Jun Imamura et al.
Masamichi Kimura et al.
Background and aims: The conserved human correlate of interleukin-18 receptor 1 (IL-18R1)-associated immune states in hepatocellular carcinoma (HCC) remains undefined. We aimed to identify a minimal, reproducible, immune-...
Safety and feasibility of 5T4 antibody-coupled allogeneic NK cell therapy for solid tumors: a first-in-human phase 1 trial [0.03%]
一项针对实体瘤的5T4抗体耦联同种异体NK细胞疗法的安全性和可行性I期临床试验：首个人体试验
Liangjie Sun,Peiwen Ma,Zhenwei Miao et al.
Liangjie Sun et al.
Background: Patients with unresectable locally advanced or metastatic solid tumors have limited therapeutic options. Antibody-guided allogeneic natural killer (NK) cell therapy represents a novel immunotherapeutic strateg...
Time-dependent cytokine landscapes in an ex vivo microfluidic glioblastoma platform [0.03%]
具有时间依赖性细胞因子景观的体外微流控胶质母细胞瘤模型
Amr Moursi,Antonia Barry,Lauric Feugere et al.
Amr Moursi et al.
Glioblastoma (GBM) is the most common and aggressive astrocytic glioma of the central nervous system with a median survival of 15 months from diagnosis. Patient outcomes have improved only marginally over the past 20 years, and GBM research...