DLGAP5 promotes gallbladder cancer migration and tumor-associated macrophage M2 polarization by activating cAMP [0.03%]
DLGAP5通过激活cAMP促进胆囊癌转移和肿瘤相关巨噬细胞M2极化
Jie Huang,Mengyao Zheng,Yan Li et al.
Jie Huang et al.
Background: Although disc large associated protein family (DLGAP5) has been reported to be involved in a variety of tumor pathologic processes, its expression and mechanism in gallbladder cancer (GBC) are still uncertain....
CD24 is a novel target of chimeric antigen receptor T cells for the treatment of triple negative breast cancer [0.03%]
靶向CD24的嵌合抗原受体T细胞治疗三阴性乳腺癌的新方法
Peiwei Yang,Fan Yu,Zheng Yao et al.
Peiwei Yang et al.
Triple negative breast cancer (TNBC) is a subtype of breast cancer with the highest degree of malignancy and the worst prognosis. The application of immunotherapy for TNBC is limited. This study was to verify the potential application of ch...
Revealing the impact of CD70 expression on the manufacture and functions of CAR-70 T-cells based on single-cell transcriptomics [0.03%]
基于单细胞转录组学揭示CD70表达对CAR-70 T细胞制备及功能影响的研究
Jiali Cheng,Yuyan Zhao,Hui Hu et al.
Jiali Cheng et al.
Background: Chimeric antigen receptor-modified T cells (CAR T-cells) have shown exhilarative clinical efficacy for hematological malignancies. However, a shared antigen pool between healthy and malignant T-cells remains a...
Prognostic survival biomarkers of tumor-fused dendritic cell vaccine therapy in patients with newly diagnosed glioblastoma [0.03%]
新诊断胶质母细胞瘤患者肿瘤融合树突状细胞疫苗治疗的预后生存生物标志物
Jun Takei,Yuko Kamata,Toshihide Tanaka et al.
Jun Takei et al.
Dendritic cell (DC)-based immunotherapy has been applied to glioblastoma (GBM); however, biomarkers informing response remain poorly understood. We conducted a phase I/IIa clinical trial investigating tumor-fused DC (TFDC) immunotherapy fol...
Using patient-derived tumor organoids from common epithelial cancers to analyze personalized T-cell responses to neoantigens [0.03%]
利用常见上皮癌的患者肿瘤类器官分析新生抗原的个性化T细胞反应
Anup Y Parikh,Robert Masi,Billel Gasmi et al.
Anup Y Parikh et al.
Adoptive cell transfer of tumor-infiltrating lymphocytes (TIL) can mediate durable complete responses in some patients with common epithelial cancers but does so infrequently. A better understanding of T-cell responses to neoantigens and tu...
The RIG-I agonist M8 triggers cell death and natural killer cell activation in human papillomavirus-associated cancer and potentiates cisplatin cytotoxicity [0.03%]
RIG-I激动剂M8触发人类乳头瘤病毒相关癌症的细胞死亡和自然杀伤细胞活化，并增强顺铂细胞毒性
Carlo Girone,Federica Calati,Irene Lo Cigno et al.
Carlo Girone et al.
Although the activation of innate immunity to treat a wide variety of cancers is gaining increasing attention, it has been poorly investigated in human papillomavirus (HPV)-associated malignancies. Because these tumors harbor a severely imp...
TGF-β1 mediates tumor immunosuppression aggravating at the late stage post-high-light-dose photodynamic therapy [0.03%]
高光剂量光动力治疗后期肿瘤免疫抑制加剧的介导因素TGFB1
Lingfei Han,Xiaoxian Huang,Bin Zhao et al.
Lingfei Han et al.
Photodynamic therapy (PDT) is an emerging clinical treatment that is expected to become an important adjuvant strategy for the immunotherapeutic cancer treatment. Recently, numerous works have reported combination strategies. However, clini...
Tumor immunology meets oncology (TIMO) XVI, July 07-09 2022 in Halle/Saale, Germany [0.03%]
第十六届肿瘤免疫学与肿瘤学(TIMO)大会将于2022年7月7日至9日在德国哈雷举行
Barbara Seliger
Barbara Seliger
During the TIMO meeting 2022, national and international scientists as well as clinicians gave novel insights as well as perspectives into basic and translational tumor immunology. ...
Characterization of human Fc alpha receptor transgenic mice: comparison of CD89 expression and antibody-dependent tumor killing between mouse strains [0.03%]
人Fcα受体转基因小鼠的特征研究：CD89表达及抗体依赖性肿瘤杀伤作用的小鼠品系间比较
Marjolein C Stip,J H Marco Jansen,Maaike Nederend et al.
Marjolein C Stip et al.
Since mice do not express a homologue of the human Fc alpha receptor (FcαRI or CD89), a transgenic mouse model was generated in four different backgrounds (C57BL/6, BALB/c, SCID and NXG) expressing the FcαRI under the endogenous human pro...
IL-36α inhibits melanoma by inducing pro-inflammatory polarization of macrophages [0.03%]
白细胞介素36α通过诱导促炎性巨噬细胞极化抑制黑色素瘤
Xinyi Lou,Shixin Duan,Mengkai Li et al.
Xinyi Lou et al.
Interleukin-36α (IL-36α) is essential for various inflammatory conditions, such as psoriasis and rheumatoid arthritis, whereas its role in tumor immunity is unclear. In this study, it was demonstrated that IL-36α could activate the NF-κ...