αTrop2/αCD3 bispecific protein engager-armed T cells (BATs) exhibit potent antitumor activity against nasopharyngeal carcinoma [0.03%]
双特异蛋白增强的T细胞(BATs)可有效针对鼻咽癌发挥抗肿瘤活性
Kwanpirom Suwanchiwasiri,Chalermchai Somboonpatarakun,Nan Chaiyariti et al.
Kwanpirom Suwanchiwasiri et al.
Nasopharyngeal carcinoma (NPC) remains a highly aggressive malignancy with poor outcomes in advanced and recurrent disease. Although immune checkpoint inhibitors combined with chemotherapy improve survival, many patients still experience re...
Correction: Thymic epithelial tumors at the crossroads of immunity, autoimmunity, and immunotherapy [0.03%]
纠正：免疫、自身免疫和免疫治疗交汇处的胸腺上皮肿瘤
Kübra Canaslan,Fatemeh Moeini Nia,Maria Baez et al.
Kübra Canaslan et al.
Published Erratum
Cancer immunology, immunotherapy : CII. 2026 May 6;75(6):164. DOI:10.1007/s00262-026-04407-x 2026
Artificial intelligence-powered H&E-based quantification of spatial tumor-infiltrating lymphocyte distribution identifies prognostic immune niches in colorectal cancer [0.03%]
基于人工智能的H&E染色量化空间肿瘤浸润淋巴细胞分布识别结直肠癌预后免疫微环境
Hyun-Hee Koh,Seungeun Lee,Chiyoon Oum et al.
Hyun-Hee Koh et al.
Purpose: The prognostic significance of tumor-infiltrating lymphocytes (TILs) in colorectal cancer (CRC) is well established; however, existing approaches inadequately capture their spatial distribution. We investigated t...
Rosuvastatin enhances the efficacy of venetoclax-azacitidine in older acute myeloid leukemia patients via reducing T-cell exhaustion [0.03%]
瑞舒伐他汀通过减少T细胞耗竭增强维奈克拉联合地西他滨在老年急性髓系白血病患者中的疗效
Yuanmei Zhai,Yehua Yu,Renjun Bao et al.
Yuanmei Zhai et al.
Venetoclax plus hypomethylating agents (HMAs) is a standard therapy for older or unfit patients with acute myeloid leukemia (AML); however, some patients exhibit suboptimal responses, potentially associated with T-cell exhaustion. Our precl...
Evaluation of the predictive and prognostic potential of blood immune cell profiles in metastatic cancer patients treated with immune checkpoint inhibitors [0.03%]
评估免疫检查点抑制剂治疗转移性癌症患者的血液免疫细胞谱型的预测和预后潜力
Veera Nurmela,Anna-Mari Schroderus,Satu Tiainen et al.
Veera Nurmela et al.
Immune checkpoint inhibitors (ICI) have transformed the treatment of metastatic malignancies, yet only 20-40% of unselected patients benefit. Peripheral blood could offer a minimally invasive and dynamic source for predictive biomarkers of ...
Dual-modality imaging enables longitudinal biodistribution profiling of intracerebroventricular CAR-T therapy in orthotopic glioma [0.03%]
双模态成像技术使脑室内CAR-T治疗的纵向生物分布谱分析成为可能（以正交肿瘤为例）
Chunzhao Li,Peng Zhang,Xiaobin Zhao et al.
Chunzhao Li et al.
Locoregional CAR-T delivery is increasingly explored for glioblastoma to improve intracranial tumor exposure; however, organ-level biodistribution kinetics after intracranial administration remain poorly quantified in vivo, limiting route-i...
AdvanTIG-206: a phase II, randomized study of ociperlimab plus tislelizumab and BAT1706 (bevacizumab biosimilar) versus tislelizumab and BAT1706 in first-line hepatocellular carcinoma [0.03%]
AdvanTIG-206：一项一线治疗肝细胞癌的二期、随机试验，评估ociperlimab联合tislelizumab和BAT1706（贝伐珠单抗类似药）对比tislelizumab和BAT1706的效果
Zhenggang Ren,Yao Huang,Yabing Guo et al.
Zhenggang Ren et al.
Background: Patients with hepatocellular carcinoma (HCC) have an unmet need for new therapies that improve survival. This phase II trial investigated the efficacy and safety of ociperlimab and tislelizumab plus BAT1706 (a...
Immune classification of advanced melanoma identifies non-responders to anti-PD1 therapy [0.03%]
免疫分类方法可判断出对PD1抗体治疗无响应的晚期黑色素瘤患者
Angelo Gámez-Pozo,Lucía Trilla-Fuertes,Fernando Becerril-Gómez et al.
Angelo Gámez-Pozo et al.
Background: Immunotherapy based on anti-PD1 inhibitors has significantly improved survival in advanced melanoma. However, a significant proportion of patients do not benefit, and predicting response to immunotherapy remai...
Immunological impact of tumor-draining lymph node dissection on systemic Th1-like CD4+ T cells in patients with early-stage lung cancer [0.03%]
早期肺癌患者肺肿瘤引流淋巴结清扫对系统性Th1型CD4⁺T细胞免疫的影响
Atsushi Kamigaichi,Hiroshi Kagamu,Yoshihiro Miyata et al.
Atsushi Kamigaichi et al.
Introduction: Tumor-draining lymph nodes (LNs) are critical for initiating and maintaining antitumor immunity. However, systematic LN dissection (LND) remains the standard surgical procedure for lung cancer. This study ai...
Integrating single-cell and bulk transcriptomes to reveal prognostic and immunological features of ecDNA-related genes in osteosarcoma [0.03%]
整合单细胞和bulk转录组揭示ECDNA相关基因在骨肉瘤中的预后及免疫特征
Jinyan Feng,Jianchao Liu,Houzhi Yang et al.
Jinyan Feng et al.
Background: The role of extrachromosomal DNA (ecDNA)-related genes in osteosarcoma remains largely unexplored. The aim of this study is to investigate the association between ecDNA-related genes and prognosis and tumor mi...