Comparison of clinical outcomes between early and delayed allogeneic hematopoietic stem cell transplantation for severe aplastic anemia: a single-center retrospective study [0.03%]
重度再生障碍性贫血早期与晚期异基因造血干细胞移植的临床效果比较：单中心回顾性研究
Zhengwei Tan,Yuechao Zhao,Huijin Hu et al.
Zhengwei Tan et al.
Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is the only curative therapy for severe aplastic anemia (SAA), yet the prognostic impact of the diagnostic-to-transplant interval on first allo-HSCT remains contentious. To dete...
TET2 germline mutation in a patient with sequential lymphoid malignancies: a novel case report [0.03%]
TET2基因胚系突变致淋巴细胞连续性恶性肿瘤病例报道
Xia Mao,Kefeng Shen,Jin Wang et al.
Xia Mao et al.
We report a case of a 30-year-old male patient with a germline heterozygous TET2 R1354fs mutation, who successively developed three distinct lymphoid malignancies: mixed cellularity classical Hodgkin lymphoma (MCCHL), angioimmunoblastic T-c...
Xin Wang,Feng Xue,Lei Zhang et al.
Xin Wang et al.
Congenital myelofibrosis (cMF) is a rare inherited bone marrow failure disorder. We report a 26-year-old Chinese male with a 24-year history of recurrent epistaxis and thrombocytopenia. Laboratory findings revealed severe thrombocytopenia (...
STAT6: Multidimensional analysis from hematopoietic immune regulation to pathogenesis mechanisms and therapeutic targets in hematologic malignancies [0.03%]
STAT6：从造血免疫调控到血液系统恶性肿瘤的发病机制和治疗靶点的多维度分析
Shuni Zhang,Shuzhen Xiong,Xinyang Liu et al.
Shuni Zhang et al.
Signal Transduction and Activation of Transcription 6 (STAT6) is a key molecule in the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signaling pathway. Primarily induced by Interleukin-4(IL-4) and Interleukin-13(I...
6-month Progression-Free Survival (PFS6) as a prognostic factor in large B-cell lymphoma patients undergoing chimeric antigen receptor T-cell therapy: A real-world multicenter study [0.03%]
嵌合抗原受体T细胞治疗大B细胞淋巴瘤患者的无进展生存期（PFS6）预后因素：一项真实世界多中心研究
Zhangyan Wang,Xiaoshi Liu,Huangming Hong et al.
Zhangyan Wang et al.
Chimeric antigen receptor T-cell (CAR-T) therapy has significantly improved overall survival (OS) in relapsed or refractory large B-cell lymphomas (R/R LBCL). However, factors associated with outcomes of CAR-T cell therapy in patients with ...
The novel ETV6::RARA fusion gene, identified in acute promyelocytic leukemia, is sensitive to invitro all-tans retinoic acid and arsenic trioxide administrations [0.03%]
新发现的ETV6::RARA融合基因敏感于维甲酸和三氧化二砷的体外治疗
Mohammad Arian Hassani,Dan Huang,Yuan Gao et al.
Mohammad Arian Hassani et al.
Acute promyelocytic leukemia (APL) is characterized by the presence of PML::RARA fusion gene, and a favorable response to all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) administration. Here, we studied the leukemogenic properties...
Incidence, clinical features and risk factors of interstitial pneumonia in children with acute lymphoblastic leukemia [0.03%]
儿童急性淋巴细胞白血病间质性肺疾病的发病、临床特征和危险因素分析
Yu Li,Zhong Fan,Li-Na Wang et al.
Yu Li et al.
Interstitial pneumonia (IP) is an important pulmonary complication in children with acute lymphoblastic leukemia (ALL), yet its incidence, clinical characteristics, and predictors remain insufficiently defined. We conducted a single-center ...
Efficacy of venetoclax-obinutuzumab treatment in achieving remission of acquired von Willebrand syndrome in chronic lymphocytic leukemia [0.03%]
维奈克拉-奥比妥珠单抗治疗使慢性淋巴细胞白血病获得性von Willebrand综合征缓解的疗效
Francesca Morelli,Silvia Linari,Chiara Maria Rapolla et al.
Francesca Morelli et al.
Venetoclax-obinutuzumab therapy successfully induced remission of acquired von Willebrand syndrome (AVWS) in a 72-year-old patient with chronic lymphocytic leukemia (CLL). Initially diagnosed with CLL, the patient later experienced severe b...
CLL-1: An emerging target for immunotherapy in acute myeloid leukemia [0.03%]
CLL-1：急性髓系白血病免疫疗法的新兴靶点
Yu Wang,Yi Xiao
Yu Wang
AML is an aggressive haematological malignancy characterised by uncontrolled proliferation and differentiation arrest of myeloid progenitor/stem cells. Conventional treatment methods principally entail chemotherapy and haematopoietic stem c...
Role of cystatin C in predicting the risk of hypermethotrexemia and kidney injury after high-dose methotrexate chemotherapy in childhood acute lymphoblastic leukemia [0.03%]
儿童急性淋巴细胞白血病大剂量甲氨蝶呤化疗后胱抑素C预测高甲氨蝶呤血症及肾损伤的作用研究
Wenting Pei,Xiao Zhang,Li-An Du et al.
Wenting Pei et al.
This study analyzed the correlation among serum cystatin C (CysC) levels, hypermethotrexemia, and kidney damage following high-dose methotrexate (HD-MTX) chemotherapy in children with acute lymphoblastic leukemia (ALL) to aid early predicti...