Cleavage site specificity of cathepsin K toward cartilage proteoglycans and protease complex formation [0.03%]
关于猫hepsin K对软骨蛋白多糖的切割位点特异性和蛋白酶复合物形成
Wu-Shiun Hou,Zhenqiang Li,Frank H Büttner et al.
Wu-Shiun Hou et al.
Cathepsin K is a potent extracellular matrix-degrading protease that requires interactions with soluble glycosaminolycans for its collagenolytic activity in bone and cartilage. The major sources of glycosaminoglycans in cartilage are aggrec...
Insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors [0.03%]
猫hepsin特异抑制剂揭示的cathepsin在抗原加工和呈递中的作用机制的见解
Nobuhiko Katunuma,Yoichi Matsunaga,Kunisuke Himeno et al.
Nobuhiko Katunuma et al.
Eleven human cathepsins have been identified, however, the in vivo roles of individual cathepsins are still largely unknown. In this brief review we will summarize the functions of individual cathepsins in antigen processing and presentatio...
Alan J Barrett,Dominic P Tolle,Neil D Rawlings
Alan J Barrett
The enzymes that hydrolyse peptide bonds, called peptidases or proteases, are very important to mankind and are also very numerous. The many scientists working on these enzymes are rapidly acquiring new data, and they need good methods to s...
Structural basis of the matrix metalloproteinases and their physiological inhibitors, the tissue inhibitors of metalloproteinases [0.03%]
基质金属蛋白酶及其生理抑制剂(金属蛋ainterleukin-1抑制蛋白)的结构基础
Wolfram Bode,Klaus Maskos
Wolfram Bode
The matrix metalloproteinases (MMPs) constitute a family of multidomain zinc endopeptidases with a metzincin-like catalytic domain, which are involved in extracellular matrix degradation but also in a number of other important biological pr...
Ciara A Ryan,Guy S Salvesen
Ciara A Ryan
Recent developments have shown that inappropriate activation of apoptotic pathways contributes to many neurodegenerative diseases. The basic mechanisms that underlie apoptosis in neurodegenerative diseases are uncertain, although they likel...
Molecular regulation of human cathepsin B: implication in pathologies [0.03%]
人类组织蛋白酶B的分子调控及其病理意义研究进展
Shiqing Yan,Bonnie F Sloane
Shiqing Yan
Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells. This protease has been implicate...
Dorit K Nägler,Robert Ménard
Dorit K Nägler
Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes. Kinetic data available to date for this l...
Vito Turk--30 years of research on cysteine proteases and their inhibitors [0.03%]
维托·特克——三十年的丝氨酸蛋白酶和它们抑制剂的研究之路
Boris Turk,Hans Fritz
Boris Turk
Differences in the activation mechanism between the alpha and beta subunits of human meprin [0.03%]
人源meprin的α和β亚基激活机制的区别研究
Christoph Becker,Markus-N Kruse,Kristina A Slotty et al.
Christoph Becker et al.
Meprins are zinc-endopeptidases of the astacin family, which are expressed as membrane-bound or secreted forms in renal and intestinal brush-border membranes of mouse, rat and man. There are two types of meprin subunits, alpha and beta, whi...
Quantification of elastase-like activity in 13 human cancer cell lines and in an immortalized human epithelial cell line by RP-HPLC [0.03%]
反相高效液相色谱法测定13个人类癌细胞株和一个永生化的人类上皮细胞株中类似弹性蛋白酶的活性
Karin Achilles,Patrick J Bednarski
Karin Achilles
A sensitive and specific RP-HPLC assay was developed to measure the levels of polymorphonuclear elastase (PMN-E) activity in growing cell cultures. By combining a pre-incubation of the cells with a relatively non-toxic, PMN-E-specific inhib...
Comparative Study
Biological chemistry. 2003 May;384(5):817-24. DOI:10.1515/BC.2003.091 2003