Sebastian Maurer-Stroh,Stefan Washietl,Frank Eisenhaber
Sebastian Maurer-Stroh
Lipid modification of eukaryotic proteins by protein prenyltransferases is required for critical signaling pathways, cell cycle progression, cytoskeleton remodeling, induction of apoptosis and vesicular trafficking. This review analyzes the...
T47-D cells and type V collagen: a model for the study of apoptotic gene expression by breast cancer cells [0.03%]
T47-D细胞和V型胶原蛋白：乳腺癌细胞凋亡基因表达研究的模型
Claudio Luparello,Fabio David,Giovanna Campisi et al.
Claudio Luparello et al.
We have previously reported that type V collagen is a poorly adhesive, anti-proliferative and motility-inhibitory substrate for the 8701-BC breast cancer cell line, which also triggers DNA fragmentation and impairs survival of the same cell...
Heat stress-dependent DNA binding of Arabidopsis heat shock transcription factor HSF1 to heat shock gene promoters in Arabidopsis suspension culture cells in vivo [0.03%]
HSF1与拟南芥悬滴培养细胞中热激蛋白基因启动子的热应力依赖性结合
Lemin Zhang,Christian Lohmann,Ralf Prändl et al.
Lemin Zhang et al.
Using UV laser cross-linking and immunoprecipitation we measured the in vivo binding of Arabidopsis heat shock transcription factor HSF1 to the promoters of target genes, Hsp18.2 and Hsp70. The amplification of promoter sequences, co-precip...
The calpastatin-derived calpain inhibitor CP1B reduces mRNA expression of matrix metalloproteinase-2 and -9 and invasion by leukemic THP-1 cells [0.03%]
从卡帕斯丁衍生的卡巴辛抑制剂CP1B降低白血病THP-1细胞中基质金属蛋白酶-2和-9的mRNA表达以及侵袭力
Oliver Popp,Michael Heidinger,Lourdes Ruiz-Heinrich et al.
Oliver Popp et al.
The ubiquitous proteases mu- and m-calpain are Ca(2+)-dependent cysteine endopeptidases. Besides involvement in a variety of physio(patho)logical processes, recent studies suggest a pivotal role of calpains in differentiation of hematopoiet...
Attila Farkas,Peter Tompa,Peter Friedrich
Attila Farkas
The abundance of mRNAs transcribed from human genes of the calpain superfamily was studied in 72 human tissues and cell types by the Human Multiple Tissue Expression (MTE) Array technique. The analysis included the large subunits of mu- and...
Effect of plant Kunitz inhibitors from Bauhinia bauhinioides and Bauhinia rufa on pulmonary edema caused by activated neutrophils [0.03%]
巴西两药花和红羊蹄甲植物中的KUNITZ抑制剂对活化中性粒细胞引起的肺水肿的影响
Christiane Neuhof,Maria Luiza V Oliva,Dirk Maybauer et al.
Christiane Neuhof et al.
Mediators released from polymorphonuclear neutrophils, in particular elastase, are known to induce acute edematous lung injury. In this study we show that the pulmonary edema in isolated perfused rabbit lungs caused by activated neutrophils...
Attenuated kinin release from human neutrophil elastase-pretreated kininogens by tissue and plasma kallikreins [0.03%]
人中性粒细胞弹性蛋白酶处理的激肽原经组织和血浆激肽释放素酶水解后呈减弱型释放态
Robert Dulinski,Piotr Suder,Ibeth Guevara-Lora et al.
Robert Dulinski et al.
Components of kinin-forming systems operating at inflammatory sites are likely to interact with elastase that is released by recruited neutrophils and may, at least temporarily, constitute the major proteolytic activity present at these sit...
Procongopain from Trypanosoma congolense is processed at basic pH: an unusual feature among cathepsin L-like cysteine proteases [0.03%]
一种罕见的溶酶体半胱氨酸蛋白酶特性：T.congolense的Procongopain在碱性pH值下加工成熟
Carole Serveau,Alain Boulangé,Fabien Lecaille et al.
Carole Serveau et al.
Congopain, the major cysteine protease from Trypanosoma congolense, is synthesized as an inactive zymogen, and further converted into its active form after removal of the proregion, most probably via an autocatalytic mechanism. Processing o...
Isolation and characterization of a novel and potent inhibitor of Arg-gingipain from Streptomyces sp. strain FA-70 [0.03%]
一株链霉菌（FA-70型）中新型强效精氨酸 gingipain 抑制剂的分离鉴定
Tomoko Kadowaki,Shizuo Kitano,Atsuyo Baba et al.
Tomoko Kadowaki et al.
Arg-gingipain (Rgp) is a major cysteine proteinase produced by the oral bacterium Porphyromonas gingivalis, which is a major pathogen of advanced periodontal diseases. This enzyme is important for the bacterium both to exhibit its virulence...
Toward computer-based cleavage site prediction of cysteine endopeptidases [0.03%]
基于计算机的半胱氨酸内肽酶裂解位点预测研究进展
Tobias Lohmüller,Daniel Wenzler,Sascha Hagemann et al.
Tobias Lohmüller et al.
Identification of relevant substrates is essential for elucidation of in vivo functions of peptidases. The recent availability of the complete genome sequences of many eukaryotic organisms holds the promise of identifying specific peptidase...