Ken-ichi Hatano,Masaki Kojima,Ei-ichiro Suzuki et al.
Ken-ichi Hatano et al.
Ribonuclease (RNase) T1 is a guanyloribonuclease, having two isozymes in nature, Gln25- and Lys25-RNase T1. Between these two isozymes, there is no difference in catalytic activity and three-dimensional structure; however, Lys25-RNase T1 is...
Assignment of disulphide bridges in Par j 2.0101, a major allergen of Parietaria judaica pollen [0.03%]
_PAR j 2.0101中的二硫键归属鉴定:牻牛儿苗属犹太植物花粉的主要过敏原_
Angela Amoresano,Piero Pucci,Giovanni Duro et al.
Angela Amoresano et al.
Par j 2.0101, a major allergen of the Parietaria judaica pollen, was expressed in E. coli, purified to homogeneity and fully characterised both at the structural and the functional level. The recombinant rPar j 2.0101 protein showed an alle...
The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6 [0.03%]
布卢姆综合症解旋酶与人类错配修复蛋白hMSH6直接相互作用
Graziella Pedrazzi,Csanád Z Bachrati,Nives Selak et al.
Graziella Pedrazzi et al.
Bloom's syndrome (BS) is a rare genetic disorder characterised by genome instability and cancer susceptibility. BLM, the BS gene product, belongs to the highly-conserved RecQ family of DNA helicases. Although the exact function of BLM in hu...
Cloning and characterization of the promoter region of the mouse frizzled-related protein 4 gene [0.03%]
鼠frizzled相关蛋白4基因启动子的克隆与鉴定
Vincent Kam Wai Wong,Judy Wai Ping Yam,W L Wendy Hsiao
Vincent Kam Wai Wong
Frizzled-related protein (Frp) is a newly identified family of secreted proteins involved in the Wnt signaling pathway. To date, little is known about the underlying mechanisms regulating Frp expression. In this study the promoter region of...
Differential haemoglobin gene expression in the crustacean Daphnia magna exposed to different oxygen partial pressures [0.03%]
不同氧分压下水蚤(Daphnia Magna)的血红蛋白基因差异表达研究
Bettina Zeis,Bertram Becher,Torsten Goldmann et al.
Bettina Zeis et al.
The quantity and quality of the haemoglobin (Hb) of Daphnia magna is related to oxygen partial pressure in the water. Both the dynamics of hypoxia-induced Hb gene transcription, as well as Hb properties in animals incubated long-term at hyp...
Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrins [0.03%]
尿激酶型纤溶酶原激活系统与整合素的分子和功能相互依赖性
Ute Reuning,Viktor Magdolen,Sandra Hapke et al.
Ute Reuning et al.
The serine protease urokinase-type plasminogen activator (uPA), its inhibitor PAI-1, and its cellular receptor uPA-R (CD87) are of crucial importance during cellular invasion and migration, required for a variety of physio- and pathophysiol...
Dieter Hoffmann,Irmgard Assfalg-Machleidt,Hans Nitschko et al.
Dieter Hoffmann et al.
A phenotypic resistance test based on recombinant expression of the active HIV protease in E. coli from patient blood samples was developed. The protease is purified in a rapid one-step procedure as active enzyme and tested for inhibition b...
Comparative Study
Biological chemistry. 2003 Jul;384(7):1109-17. DOI:10.1515/BC.2003.124 2003
Expression of high molecular weight cysteine proteinase inhibitor in ovarian cancer tissues: regulation of cathepsin B expression by placental CPI [0.03%]
卵巢癌组织中高分子量半胱氨酸蛋白酶抑制物的表达：胎盘CPI对猫淋巴肿瘤坏死因子B表达的影响
Maciej Siewiński,Yousif Saleh,Andrzej Popiela et al.
Maciej Siewiński et al.
Mouse polyclonal antibodies against placental cysteine proteinase inhibitor (CPI) react with the placental 67 kDa CPI on Western blots, and CPI present in ovarian cancer homogenate and serum was shown by double immunodiffusion to react with...
Comparative Study
Biological chemistry. 2003 Jul;384(7):1103-7. DOI:10.1515/BC.2003.123 2003
Inhibition of intraperitoneal tumor growth of human ovarian cancer cells by bi- and trifunctional inhibitors of tumor-associated proteolytic systems [0.03%]
用人卵巢癌细胞抑制腹膜肿瘤生长的相关蛋白酶系统的双功能和三功能抑制剂的作用研究
Janna Krol,Charlotte Kopitz,Angela Kirschenhofer et al.
Janna Krol et al.
Several proteolytic systems are involved in (anti)adhesive, migratory, and proteolytic processes, necessary for tumor progression and metastasis. We analyzed whether multifunctional inhibitors of different tumor-associated proteolytic syste...
Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [0.03%]
新型的针对肿瘤相关蛋白水解系统的双功能和三功能抑制剂
Janna Krol,Sumito Sato,Peter Rettenberger et al.
Janna Krol et al.
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCys-uPA19-31) directed against cysteine proteases and the urok...